Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol
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 PubChem ID
CID: 5405
SID: 14907543
Canonical SMILES
CC(C)(C)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1
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Compound Formula C32H41NO2
Compound Structure
Protein Name
 Protein Info 
Potassium voltage-gated channel subfamily H member 2
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Voltage-gated potassium channel
Uniprot ID
Q12809
Gene Name
KCNH2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
2
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
2
IC50 = 30 nM
   TI
   LI
   LO
   TS
3
IC50 = 56 nM
   TI
   LI
   LO
   TS
4
IC50 = 204 nM
   TI
   LI
   LO
   TS
5
IC50 = 350 nM
   TI
   LI
   LO
   TS
6
IC50 = 960 nM
   TI
   LI
   LO
   TS
7
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 128.82 nM
   TI
   LI
   LO
   TS
CL000309 NCTC clone 929
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 312 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 50 nM
2 IC50 = 56 nM
3 IC50 = 199.53 nM
4 IC50 = 213 nM
5 IC50 = 213.8 nM
6 Ki = 56 nM
7 Ki = 78 nM
8 Ki = 320 nM