Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
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 PubChem ID
CID: 5329102
SID: 14830382
Canonical SMILES
CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
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Compound Formula C22H27FN4O2
Compound Structure
Protein Name
 Protein Info 
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  1
1
GI50 = 33 nM
   TI
   LI
   LO
   TS
CL000749 HUVEC-C
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS
CL000118 U-251MG
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 18.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.4 nM
2 IC50 = 4 nM
3 IC50 = 5.5 nM
4 IC50 = 5.7 nM
5 IC50 = 8 nM
6 IC50 = 9 nM
7 IC50 = 10 nM
8 IC50 = 12 nM
9 IC50 = 15 nM
10 IC50 = 18 nM
11 IC50 = 22.6 nM
12 IC50 = 25 nM
13 IC50 = 27 nM
14 IC50 = 29.2 nM
15 IC50 = 37 nM
16 IC50 = 38 nM
17 IC50 = 39 nM
18 IC50 = 40 nM
19 IC50 = 54 nM
20 IC50 = 70 nM
21 IC50 = 75 nM
22 IC50 = 75.9 nM
23 IC50 = 80 nM
24 IC50 = 95 nM
25 IC50 = 98 nM
26 IC50 = 139 nM
27 IC50 = 147 nM
28 IC50 = 185 nM
29 Kd = 0.2 nM
30 Kd = 0.23 nM
31 Kd = 1.5 nM
32 Kd = 30 nM
33 Ki = 2.9 nM
34 Ki = 9 nM