General Information of the Protein
Protein ID
PT06676
Protein Name
Fusion glycoprotein F0
Secondarily
Protein Name
Intervening segment
Pep27
Peptide 27
Gene Name
F
Sequence
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPPTNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEINLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGMDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
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Organism
Human respiratory syncytial virus A (strain A2)
Protein Classification
Surface antigen
Function
Inactive precursor that is cleaved at two sites by a furin-like protease to give rise to the mature F1 and F2 fusion glycoproteins.
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Uniprot ID
Primary ID:
P03420

Secondarily ID:
P88811
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Subcellular Location
Host Golgi apparatus membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000668 , HEp-2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0557671
 Compound Info 
(2S)-23-[(3S)-3-aminopyrrolidin-1-yl]-11,20-dimethyl-15-oxa-7,20,24,26,27-pentazapentacyclo[23.2.1.02,7.09,14.021,26]octacosa-1(27),9(14),10,12,21,23,25(28)-heptaen-8-one
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C28H37N7O2
  1
1
EC50 = 8.1 nM
 Bioactivity Info 
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CP0437310
 Compound Info 
(2S)-19-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,16-trimethyl-11-oxa-3,16,20,22,23-pentazatetracyclo[19.2.1.05,10.017,22]tetracosa-1(23),5(10),6,8,17,19,21(24)-heptaen-4-one
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C27H37N7O2
  1
1
EC50 = 440 nM
 Bioactivity Info 
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CP0526754
 Compound Info 
GS-5806
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C24H30ClN7O3S
  1
1
EC50 = 1193 nM
 Bioactivity Info 
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CP0409299
 Compound Info 
(2S)-20-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,17-trimethyl-11-oxa-3,17,21,23,24-pentazatetracyclo[20.2.1.05,10.018,23]pentacosa-1(24),5(10),6,8,18,20,22(25)-heptaen-4-one
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C28H39N7O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0414427
 Compound Info 
N-[(1S)-1-[5-[(3S)-3-aminopyrrolidin-1-yl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl]propyl]-2-methoxy-N,5-dimethylbenzamide
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C24H32N6O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0420336
 Compound Info 
(2S)-19-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,18-trimethyl-11-oxa-3,16,20,22,23-pentazatetracyclo[19.2.1.05,10.017,22]tetracosa-1(23),5(10),6,8,17,19,21(24)-heptaen-4-one
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C27H37N7O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0437312
 Compound Info 
(2S)-21-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,18-trimethyl-11-oxa-3,18,22,24,25-pentazatetracyclo[21.2.1.05,10.019,24]hexacosa-1(25),5(10),6,8,19,21,23(26)-heptaen-4-one
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C29H41N7O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0437313
 Compound Info 
(2S)-18-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,15-trimethyl-11-oxa-3,15,19,21,22-pentazatetracyclo[18.2.1.05,10.016,21]tricosa-1(22),5(10),6,8,16,18,20(23)-heptaen-4-one
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C26H35N7O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0526753
 Compound Info 
(2S)-19-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7-dimethyl-11-oxa-3,16,20,22,23-pentazatetracyclo[19.2.1.05,10.017,22]tetracosa-1(23),5(10),6,8,17,19,21(24)-heptaen-4-one
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C26H35N7O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0531760
 Compound Info 
(2S)-19-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,16,18-tetramethyl-11-oxa-3,16,20,22,23-pentazatetracyclo[19.2.1.05,10.017,22]tetracosa-1(23),5(10),6,8,17,19,21(24)-heptaen-4-one
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C28H39N7O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Respiratory syncytial virus protein F (RSV F) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Osteoporosis [ICD-11: FB83.0]
2 Respiratory syncytial virus infection [ICD-11: 1C80]
Approved Drug(s) 1 Approved Drug  1
1 Lasofoxifene
 Drug Info 
Approved
Osteoporosis
Clinical Trial Drug(s) 3 Clinical Trial Drugs  3
1 GS-5806
 Drug Info 
Phase 2
Respiratory syncytial virus infection
2 JNJ-53718678
 Drug Info 
Phase 2
Respiratory syncytial virus infection
3 RV521
 Drug Info 
Phase 2
Respiratory syncytial virus infection
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00459 Fusion glycoprotein F0 Human respiratory syncytial virus
 Protein Info