General Information of the Protein
Protein ID
PT00459
Protein Name
Fusion glycoprotein F0
Gene Name
F
Sequence
MELPILKANAITTILAAVTFCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLMKQELDKYKNAVTELQLLMQSTPAANNRARRELPRFMNYTLNNTKKTNVTLSKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCRISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
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Organism
Human respiratory syncytial virus
Protein Classification
Surface antigen
Function
Inactive precursor that is cleaved at two sites by a furin-like protease to give rise to the mature F1 and F2 fusion glycoproteins.
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Uniprot ID
Q89535
Subcellular Location
Cell membrane
Host Golgi apparatus membrane
Host cell membrane
Membrane
Membrane
Virion membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000668 , HEp-2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0526754
 Compound Info 
GS-5806
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C24H30ClN7O3S
  1
1
EC50 = 0.1 nM
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CP0437310
 Compound Info 
(2S)-19-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,16-trimethyl-11-oxa-3,16,20,22,23-pentazatetracyclo[19.2.1.05,10.017,22]tetracosa-1(23),5(10),6,8,17,19,21(24)-heptaen-4-one
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C27H37N7O2
  1
1
EC50 = 0.66 nM
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CP0534543
 Compound Info 
propan-2-yl 1'-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-2'-oxospiro[azetidine-3,3'-indole]-1-carboxylate
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C26H29BrN4O4
  1
1
EC50 = 0.8 nM
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CP0552508
 Compound Info 
4-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]-1,1,1-trifluorobutan-2-ol
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C19H17ClF3N5O3S
  1
1
EC50 = 1 nM
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CP0541273
 Compound Info 
N'-[2-(1,1-dioxo-3,5-dihydro-2H-1lambda6,4-benzothiazepin-4-yl)-6-methylquinolin-4-yl]propane-1,3-diamine
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C22H26N4O2S
  1
1
EC50 = 1 nM
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CP0420336
 Compound Info 
(2S)-19-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,18-trimethyl-11-oxa-3,16,20,22,23-pentazatetracyclo[19.2.1.05,10.017,22]tetracosa-1(23),5(10),6,8,17,19,21(24)-heptaen-4-one
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C27H37N7O2
  1
1
EC50 = 1.4 nM
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CP0411864
 Compound Info 
1'-[[7-chloro-3-(3-methylsulfonylpropyl)imidazo[1,2-a]pyridin-2-yl]methyl]spiro[cyclopropane-1,3'-pyrrolo[2,3-c]pyridine]-2'-one
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C21H21ClN4O3S
  1
1
EC50 = 2 nM
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CP0396334
 Compound Info 
N-[(3-aminooxetan-3-yl)methyl]-2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-amine
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C24H27FN4O
  3
1
EC50 = 2 nM
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2
EC50 = 4 nM
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3
IC50 = 2560 nM
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CP0557671
 Compound Info 
(2S)-23-[(3S)-3-aminopyrrolidin-1-yl]-11,20-dimethyl-15-oxa-7,20,24,26,27-pentazapentacyclo[23.2.1.02,7.09,14.021,26]octacosa-1(27),9(14),10,12,21,23,25(28)-heptaen-8-one
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C28H37N7O2
  1
1
EC50 = 2 nM
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CP0519630
 Compound Info 
1'-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C22H22BrN3O2
  1
1
EC50 = 2.3 nM
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CP0389296
 Compound Info 
3-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]propan-1-ol
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C18H18ClN5O3S
  1
1
EC50 = 3 nM
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CP0478152
 Compound Info 
4-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]-1,1-difluorobutan-2-ol
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C19H18ClF2N5O3S
  1
1
EC50 = 3 nM
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CP0472926
 Compound Info 
1'-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1-(2-methylpropanoyl)spiro[azetidine-3,3'-indole]-2'-one
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C26H29BrN4O3
  1
1
EC50 = 3 nM
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CP0536963
 Compound Info 
1'-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1-methylsulfonylspiro[azetidine-3,3'-indole]-2'-one
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C23H25BrN4O4S
  1
1
EC50 = 3 nM
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CP0493235
 Compound Info 
1-[[5-chloro-1-(5,5,5-trifluoropentyl)benzimidazol-2-yl]methyl]-3-methylsulfonylpyrazolo[3,4-c]pyridine
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C20H19ClF3N5O2S
  1
1
EC50 = 3.4 nM
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CP0414427
 Compound Info 
N-[(1S)-1-[5-[(3S)-3-aminopyrrolidin-1-yl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl]propyl]-2-methoxy-N,5-dimethylbenzamide
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C24H32N6O2
  1
1
EC50 = 3.8 nM
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CP0411830
 Compound Info 
4-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]butan-1-ol
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C19H20ClN5O3S
  1
1
EC50 = 4 nM
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CP0476904
 Compound Info 
N'-[2-(1,1-dioxo-3,5-dihydro-2H-1lambda6,4-benzothiazepin-4-yl)-6-methylquinolin-4-yl]ethane-1,2-diamine
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C21H24N4O2S
  1
1
EC50 = 4 nM
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CP0493234
 Compound Info 
1-[[5-chloro-1-(3,3,3-trifluoropropyl)benzimidazol-2-yl]methyl]-3-methylsulfonylpyrazolo[3,4-c]pyridine
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C18H15ClF3N5O2S
  1
1
EC50 = 4.3 nM
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CP0389295
 Compound Info 
1-[[5-chloro-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-3-methylsulfonylpyrazolo[3,4-c]pyridine
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C19H20ClN5O4S2
  1
1
EC50 = 5 nM
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CP0561839
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[indole-3,3'-thietane]-2-one
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C22H22BrN3O2S
  1
1
EC50 = 5 nM
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CP0396333
 Compound Info 
N-[3-(aminomethyl)oxetan-3-yl]-2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-amine
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C24H27FN4O
  1
1
EC50 = 5 nM
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CP0072620
 Compound Info 
1-[[5-chloro-1-(oxetan-3-ylmethyl)benzimidazol-2-yl]methyl]-3-methylsulfonylpyrazolo[3,4-c]pyridine
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C19H18ClN5O3S
  1
1
EC50 = 5.4 nM
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CP0561838
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[indole-3,4'-oxane]-2-one
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C24H26BrN3O3
  1
1
EC50 = 6 nM
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CP0409299
 Compound Info 
(2S)-20-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,17-trimethyl-11-oxa-3,17,21,23,24-pentazatetracyclo[20.2.1.05,10.018,23]pentacosa-1(24),5(10),6,8,18,20,22(25)-heptaen-4-one
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C28H39N7O2
  1
1
EC50 = 6.2 nM
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CP0552510
 Compound Info 
5-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]-2-methylpentan-2-ol
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C21H24ClN5O3S
  1
1
EC50 = 7 nM
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CP0567404
 Compound Info 
1'-[[5-(aminomethyl)-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C23H26N4O2
  1
1
EC50 = 7 nM
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CP0539791
 Compound Info 
N'-[2-(1,1-dioxo-3,5-dihydro-2H-1lambda6,4-benzothiazepin-4-yl)-6-methylquinolin-4-yl]butane-1,4-diamine
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C23H28N4O2S
  1
1
EC50 = 7 nM
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CP0478151
 Compound Info 
4-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]-2-methylbutan-2-ol
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C20H22ClN5O3S
  1
1
EC50 = 7.9 nM
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CP0472923
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[indole-3,3'-oxolane]-2-one
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C23H24BrN3O3
  1
1
EC50 = 8 nM
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CP0534542
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1'-methylsulfonylspiro[indole-3,3'-pyrrolidine]-2-one
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C24H27BrN4O4S
  1
1
EC50 = 8 nM
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CP0531760
 Compound Info 
(2S)-19-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,16,18-tetramethyl-11-oxa-3,16,20,22,23-pentazatetracyclo[19.2.1.05,10.017,22]tetracosa-1(23),5(10),6,8,17,19,21(24)-heptaen-4-one
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C28H39N7O2
  1
1
EC50 = 8.1 nM
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CP0411862
 Compound Info 
1-[[5-chloro-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-N,N-dimethylindole-3-sulfonamide
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C22H25ClN4O4S2
  1
1
EC50 = 10 nM
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CP0515513
 Compound Info 
1'-[[5-chloro-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C22H22ClN3O2
  1
1
EC50 = 10 nM
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CP0536881
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1'-(2-methylpropanoyl)spiro[indole-3,3'-pyrrolidine]-2-one
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C27H31BrN4O3
  1
1
EC50 = 10 nM
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CP0408528
 Compound Info 
2-N-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]propane-1,2-diamine
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C23H27FN4
  1
1
EC50 = 10 nM
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CP0472925
 Compound Info 
propan-2-yl 1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-2-oxospiro[indole-3,3'-pyrrolidine]-1'-carboxylate
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C27H31BrN4O4
  1
1
EC50 = 11 nM
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CP0429415
 Compound Info 
N'-[2-(1,1-dioxo-3,5-dihydro-2H-1lambda6,4-benzothiazepin-4-yl)quinolin-4-yl]ethane-1,2-diamine
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C20H22N4O2S
  1
1
EC50 = 11 nM
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CP0536091
 Compound Info 
5-chloro-2-[(3-methylsulfonylindazol-1-yl)methyl]-1-(3-methylsulfonylpropyl)benzimidazole
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C20H21ClN4O4S2
  1
1
EC50 = 12 nM
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CP0536100
 Compound Info 
2-[2-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]ethoxy]ethanol
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C19H20ClN5O4S
  1
1
EC50 = 12 nM
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CP0558759
 Compound Info 
1-N-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]-2-methylpropane-1,2-diamine
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C24H29FN4
  1
1
EC50 = 12 nM
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CP0567403
 Compound Info 
1'-[[5-fluoro-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C22H22FN3O2
  1
1
EC50 = 13 nM
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CP0539792
 Compound Info 
1-N-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]propane-1,2-diamine
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C23H27FN4
  1
1
EC50 = 14 nM
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CP0569239
 Compound Info 
N'-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]-N-methylethane-1,2-diamine
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C23H27FN4
  1
1
EC50 = 14 nM
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CP0567400
 Compound Info 
1'-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C22H23N3O2
  1
1
EC50 = 15 nM
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CP0534541
 Compound Info 
1'-[[1-(4-hydroxybutyl)-5-methylbenzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C23H25N3O2
  1
1
EC50 = 16 nM
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CP0574801
 Compound Info 
1'-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-pyrrolo[2,3-c]pyridine]-2'-one
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C21H22N4O2
  1
1
EC50 = 16 nM
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CP0574962
 Compound Info 
1'-[[7-chloro-3-(2-methylsulfonylethyl)imidazo[1,2-a]pyridin-2-yl]methyl]spiro[cyclopropane-1,3'-pyrrolo[2,3-c]pyridine]-2'-one
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C20H19ClN4O3S
  1
1
EC50 = 17 nM
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CP0437313
 Compound Info 
(2S)-18-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,15-trimethyl-11-oxa-3,15,19,21,22-pentazatetracyclo[18.2.1.05,10.016,21]tricosa-1(22),5(10),6,8,16,18,20(23)-heptaen-4-one
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C26H35N7O2
  1
1
EC50 = 17 nM
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CP0536964
 Compound Info 
1'-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[azetidine-3,3'-indole]-2'-one
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C22H23BrN4O2
  1
1
EC50 = 19 nM
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CP0036151
 Compound Info 
BMS-433771
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C21H23N5O2
  2
1
EC50 = 20 nM
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2
EC50 = 28 nM
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CP0472924
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1',1'-dioxospiro[indole-3,3'-thietane]-2-one
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C22H22BrN3O4S
  1
1
EC50 = 21 nM
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CP0532108
 Compound Info 
1'-[[1-(4-hydroxybutyl)-5-iodobenzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C22H22IN3O2
  1
1
EC50 = 21 nM
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CP0550380
 Compound Info 
2-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]ethanol
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C17H16ClN5O3S
  1
1
EC50 = 25 nM
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CP0569240
 Compound Info 
2-N-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]-2-methylpropane-1,2-diamine
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C24H29FN4
  1
1
EC50 = 25 nM
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CP0558761
 Compound Info 
2-[[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]amino]acetamide
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C22H23FN4O
  1
1
EC50 = 26 nM
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CP0565118
 Compound Info 
N'-[2-(1,1-dioxo-3,5-dihydro-2H-1lambda6,4-benzothiazepin-4-yl)-6-methylquinolin-4-yl]pentane-1,5-diamine
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C24H30N4O2S
  1
1
EC50 = 27 nM
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CP0486179
 Compound Info 
N'-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]-N-(oxetan-3-yl)ethane-1,2-diamine
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C25H29FN4O
  1
1
EC50 = 31 nM
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CP0464958
 Compound Info 
3-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]-2,2-difluoropropan-1-ol
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C18H16ClF2N5O3S
  1
1
EC50 = 35 nM
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CP0472919
 Compound Info 
6'-fluoro-1'-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C22H22FN3O2
  1
1
EC50 = 37 nM
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CP0429420
 Compound Info 
N-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]-N',N'-dimethylethane-1,2-diamine
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C24H29FN4
  1
1
EC50 = 37 nM
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CP0539790
 Compound Info 
2-amino-N-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]acetamide
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C22H23FN4O
  1
1
EC50 = 39 nM
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CP0486178
 Compound Info 
2-[[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]amino]ethanol
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C22H24FN3O
  1
1
EC50 = 41 nM
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CP0427480
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1'-(oxetan-3-yl)spiro[indole-3,4'-piperidine]-2-one
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C27H31BrN4O3
  1
1
EC50 = 42 nM
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CP0532109
 Compound Info 
1'-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1-methylspiro[azetidine-3,3'-indole]-2'-one
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C23H25BrN4O2
  1
1
EC50 = 43 nM
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CP0469722
 Compound Info 
5-chloro-2-[(3-methylsulfonylindol-1-yl)methyl]-1-(3-methylsulfonylpropyl)benzimidazole
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C21H22ClN3O4S2
  1
1
EC50 = 53 nM
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CP0411863
 Compound Info 
5-chloro-2-[(3-ethylsulfonylindol-1-yl)methyl]-1-(3-methylsulfonylpropyl)benzimidazole
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C22H24ClN3O4S2
  1
1
EC50 = 54 nM
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CP0437312
 Compound Info 
(2S)-21-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7,18-trimethyl-11-oxa-3,18,22,24,25-pentazatetracyclo[21.2.1.05,10.019,24]hexacosa-1(25),5(10),6,8,19,21,23(26)-heptaen-4-one
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C29H41N7O2
  1
1
EC50 = 54 nM
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CP0567406
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-4'-methylspiro[indole-3,2'-morpholine]-2-one
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C24H27BrN4O3
  1
1
EC50 = 55 nM
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CP0526753
 Compound Info 
(2S)-19-[(3S)-3-aminopyrrolidin-1-yl]-2-ethyl-3,7-dimethyl-11-oxa-3,16,20,22,23-pentazatetracyclo[19.2.1.05,10.017,22]tetracosa-1(23),5(10),6,8,17,19,21(24)-heptaen-4-one
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C26H35N7O2
  1
1
EC50 = 61 nM
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CP0393308
 Compound Info 
N'-[2-(5,5-difluoro-3,4-dihydro-1H-2-benzazepin-2-yl)-6-methylquinolin-4-yl]ethane-1,2-diamine
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C22H24F2N4
  1
1
EC50 = 62 nM
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CP0486177
 Compound Info 
2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methyl-N-(piperidin-2-ylmethyl)quinolin-4-amine
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C26H31FN4
  1
1
EC50 = 71 nM
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CP0429418
 Compound Info 
N'-[6-methyl-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
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C22H26N4
  1
1
EC50 = 73 nM
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CP0547904
 Compound Info 
3-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]-2,2-difluoropropan-1-amine
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C18H17ClF2N6O2S
  1
1
EC50 = 75 nM
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CP0567408
 Compound Info 
1'-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[imidazolidine-5,3'-indole]-2,2',4-trione
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C22H20BrN5O4
  1
1
EC50 = 76 nM
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CP0549826
 Compound Info 
5-chloro-1-(3-methylsulfonylpropyl)-2-[(3-methylsulfonylpyrrolo[2,3-c]pyridin-1-yl)methyl]benzimidazole
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C20H21ClN4O4S2
  1
1
EC50 = 78 nM
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CP0486401
 Compound Info 
1-[[5-chloro-1-[2-(2-methoxyethoxy)ethyl]benzimidazol-2-yl]methyl]-3-methylsulfonylpyrazolo[3,4-c]pyridine
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C20H22ClN5O4S
  1
1
EC50 = 88 nM
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CP0547872
 Compound Info 
5-chloro-1-(2-methylsulfonylethyl)-2-[(3-methylsulfonylindol-1-yl)methyl]benzimidazole
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C20H20ClN3O4S2
  1
1
EC50 = 93 nM
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CP0478150
 Compound Info 
5-chloro-1-(3-methylsulfonylpropyl)-2-[(3-propan-2-ylsulfonylindol-1-yl)methyl]benzimidazole
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C23H26ClN3O4S2
  1
1
EC50 = 100 nM
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CP0558758
 Compound Info 
N'-[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]ethane-1,2-diamine
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C22H25FN4
  1
1
EC50 = 100 nM
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CP0538739
 Compound Info 
1-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-4-methylquinolin-2-one
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C22H23N3O2
  1
1
EC50 = 110 nM
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CP0561834
 Compound Info 
1-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-4-methylquinazolin-2-one
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C21H22N4O2
  1
1
EC50 = 110 nM
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CP0429417
 Compound Info 
N'-[6-chloro-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
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C21H23ClN4
  1
1
EC50 = 120 nM
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CP0567401
 Compound Info 
1-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-3,3-dimethylindol-2-one
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C22H25N3O2
  1
1
EC50 = 130 nM
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CP0547866
 Compound Info 
5-chloro-2-[(3-cyclopropylsulfonylindol-1-yl)methyl]-1-(3-methylsulfonylpropyl)benzimidazole
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C23H24ClN3O4S2
  1
1
EC50 = 140 nM
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CP0558760
 Compound Info 
2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methyl-N-(2-piperazin-1-ylethyl)quinolin-4-amine
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C26H32FN5
  1
1
EC50 = 150 nM
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CP0411829
 Compound Info 
5-chloro-2-[(5-fluoro-3-methylsulfonylindol-1-yl)methyl]-1-(3-methylsulfonylpropyl)benzimidazole
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C21H21ClFN3O4S2
  1
1
EC50 = 180 nM
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CP0534539
 Compound Info 
4-[2-[(3-methylindazol-1-yl)methyl]benzimidazol-1-yl]butan-1-ol
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C20H22N4O
  1
1
EC50 = 180 nM
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CP0561836
 Compound Info 
1-(4-hydroxybutyl)-2-[(2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl)methyl]benzimidazole-5-carbonitrile
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C23H22N4O2
  1
1
EC50 = 190 nM
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CP0559032
 Compound Info 
1-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]indole-3-carbonitrile
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C21H20N4O
  1
1
EC50 = 200 nM
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CP0429375
 Compound Info 
N'-[2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
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C21H24N4
  2
1
EC50 = 200 nM
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2
IC50 = 2300 nM
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CP0561837
 Compound Info 
1'-[[1-(4-hydroxybutyl)-5-(trifluoromethyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C23H22F3N3O2
  1
1
EC50 = 210 nM
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CP0393310
 Compound Info 
1-amino-3-[[2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]amino]propan-2-ol
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C22H26N4O
  1
1
EC50 = 220 nM
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CP0396351
 Compound Info 
1-amino-3-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)quinolin-4-yl]amino]propan-2-ol
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C21H24N4O
  1
1
EC50 = 220 nM
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CP0464959
 Compound Info 
3-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]-1,1,1-trifluoropropan-2-amine
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C18H16ClF3N6O2S
  1
1
EC50 = 221 nM
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CP0429419
 Compound Info 
N'-[6-methyl-2-(1,2,3,5-tetrahydro-1,4-benzodiazepin-4-yl)quinolin-4-yl]ethane-1,2-diamine
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C21H25N5
  1
1
EC50 = 230 nM
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CP0558753
 Compound Info 
N'-[2-(3,5-dihydro-2H-1,4-benzoxazepin-4-yl)quinolin-4-yl]ethane-1,2-diamine
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C20H22N4O
  1
1
EC50 = 230 nM
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CP0563173
 Compound Info 
2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methyl-N-(2-piperidin-1-ylethyl)quinolin-4-amine
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C27H33FN4
  1
1
EC50 = 280 nM
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CP0478149
 Compound Info 
1-[[5-chloro-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-N-methylindole-3-sulfonamide
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C21H23ClN4O4S2
  1
1
EC50 = 290 nM
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CP0561840
 Compound Info 
1-[[5-bromo-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1'-methylspiro[indole-3,4'-piperidine]-2-one
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C25H29BrN4O2
  1
1
EC50 = 307 nM
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CP0412124
 Compound Info 
4-[4-(2-aminoethylamino)-6-methylquinolin-2-yl]-3,5-dihydro-1H-1,4-benzodiazepin-2-one
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C21H23N5O
  1
1
EC50 = 310 nM
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CP0541319
 Compound Info 
N'-[6-methoxy-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
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C22H26N4O
  1
1
EC50 = 320 nM
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CP0472920
 Compound Info 
3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1,3-benzoxazol-2-one
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C19H19N3O3
  1
1
EC50 = 350 nM
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CP0408526
 Compound Info 
N'-[2-(7-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]ethane-1,2-diamine
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C22H25FN4
  1
1
EC50 = 460 nM
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CP0534540
 Compound Info 
4-[2-[[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]methyl]benzimidazol-1-yl]butan-1-ol
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C22H21N5OS
  1
1
EC50 = 470 nM
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CP0567402
 Compound Info 
5-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-2-methyl-2,3-dihydro-1H-1,5-benzodiazepin-4-one
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C22H26N4O2
  1
1
EC50 = 480 nM
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CP0408529
 Compound Info 
2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methyl-N-(2-morpholin-4-ylethyl)quinolin-4-amine
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C26H31FN4O
  1
1
EC50 = 540 nM
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CP0515512
 Compound Info 
4-[2-(pyrrolo[2,3-c]pyridin-1-ylmethyl)benzimidazol-1-yl]butan-1-ol
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C19H20N4O
  1
1
EC50 = 1000 nM
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CP0552509
 Compound Info 
3-[5-chloro-2-[(3-methylsulfonylpyrazolo[3,4-c]pyridin-1-yl)methyl]benzimidazol-1-yl]-2,2-dimethylpropan-1-ol
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C20H22ClN5O3S
  1
1
EC50 = 1070 nM
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CP0558755
 Compound Info 
N'-[8-chloro-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
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C21H23ClN4
  1
1
EC50 = 1100 nM
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CP0558757
 Compound Info 
N'-[2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-(trifluoromethyl)quinolin-4-yl]ethane-1,2-diamine
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C22H23F3N4
  1
1
EC50 = 1100 nM
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CP0412122
 Compound Info 
N'-[6-fluoro-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
   Show/Hide
C21H23FN4
  1
1
EC50 = 1500 nM
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CP0561833
 Compound Info 
4-[2-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzimidazol-1-yl]butan-1-ol
   Show/Hide
C20H19F3N4O
  1
1
EC50 = 1700 nM
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CP0536961
 Compound Info 
4-[2-(indazol-1-ylmethyl)benzimidazol-1-yl]butan-1-ol
   Show/Hide
C19H20N4O
  1
1
EC50 = 1800 nM
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CP0561832
 Compound Info 
4-[2-(pyrazolo[3,4-c]pyridin-1-ylmethyl)benzimidazol-1-yl]butan-1-ol
   Show/Hide
C18H19N5O
  1
1
EC50 = 2200 nM
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CP0486175
 Compound Info 
N'-[2-(3,4-dihydro-1H-isoquinolin-2-yl)quinolin-4-yl]ethane-1,2-diamine
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C20H22N4
  1
1
EC50 = 2300 nM
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CP0513364
 Compound Info 
2-[2-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)quinolin-4-yl]amino]ethyl]guanidine
   Show/Hide
C21H24N6
  1
1
EC50 = 2300 nM
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CP0493124
 Compound Info 
1-(2-methylsulfonylethyl)-2-[(3-methylsulfonylindol-1-yl)methyl]benzimidazole
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C20H21N3O4S2
  1
1
EC50 = 2414 nM
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CP0558762
 Compound Info 
N-[2-[[2-(8-fluoro-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-6-methylquinolin-4-yl]amino]ethyl]acetamide
   Show/Hide
C24H27FN4O
  1
1
EC50 = 3100 nM
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CP0472922
 Compound Info 
4-[2-(1,2,3,4-tetrahydropyrido[3,4-b]indol-9-ylmethyl)benzimidazol-1-yl]butan-1-ol
   Show/Hide
C23H26N4O
  1
1
EC50 = 5000 nM
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CP0478148
 Compound Info 
1-(2-methylsulfonylethyl)-2-[(1-methylsulfonylindol-3-yl)methyl]benzimidazole
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C20H21N3O4S2
  1
1
EC50 = 5420 nM
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CP0429414
 Compound Info 
N'-[6-methylsulfonyl-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
   Show/Hide
C22H26N4O2S
  1
1
EC50 = 5600 nM
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CP0558754
 Compound Info 
N'-[5-chloro-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
   Show/Hide
C21H23ClN4
  1
1
EC50 = 6600 nM
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CP0563169
 Compound Info 
N'-[2-(3,4-dihydro-1H-isoquinolin-2-yl)quinolin-4-yl]propane-1,3-diamine
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C21H24N4
  1
1
EC50 = 7800 nM
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CP0574805
 Compound Info 
1'-[[5-cyclohexyl-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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C28H33N3O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0559033
 Compound Info 
4-[2-[(3-methyl-4,5,6,7-tetrahydroindazol-1-yl)methyl]benzimidazol-1-yl]butan-1-ol
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C20H26N4O
  1
1
EC50 = 12000 nM
 Bioactivity Info 
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CP0563171
 Compound Info 
2-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)quinolin-4-yl]amino]ethylurea
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C21H23N5O
  1
1
EC50 = 15000 nM
 Bioactivity Info 
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CP0396352
 Compound Info 
3-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)quinolin-4-yl]amino]propane-1,2-diol
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C21H23N3O2
  1
1
EC50 = 22000 nM
 Bioactivity Info 
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CP0472921
 Compound Info 
4-[2-[(3-methyl-4,5,6,7-tetrahydroindazol-2-yl)methyl]benzimidazol-1-yl]butan-1-ol
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C20H26N4O
  1
1
EC50 = 26000 nM
 Bioactivity Info 
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CP0561835
 Compound Info 
3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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C25H31N5O2
  1
1
EC50 > 50000 nM
 Bioactivity Info 
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CP0464957
 Compound Info 
1-(2-methylsulfonylethyl)-2-[(2-methylsulfonylindol-1-yl)methyl]benzimidazole
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C20H21N3O4S2
  1
1
EC50 = 100000 nM
 Bioactivity Info 
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CP0429416
 Compound Info 
1-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)quinolin-4-yl]amino]propan-2-ol
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C21H23N3O
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0486176
 Compound Info 
N'-[2-(3,4-dihydro-1H-isoquinolin-2-yl)quinolin-4-yl]butane-1,4-diamine
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C22H26N4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0569238
 Compound Info 
1-amino-3-[[2-(1,3-dihydroisoindol-2-yl)quinolin-4-yl]amino]propan-2-ol
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C20H22N4O
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0412121
 Compound Info 
N'-[7-chloro-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)quinolin-4-yl]ethane-1,2-diamine
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C21H23ClN4
  1
1
EC50 > 3200 nM
 Bioactivity Info 
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Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06676 Fusion glycoprotein F0 Human respiratory syncytial virus A (strain A2)
 Protein Info