General Information of the Protein
Protein ID
PT06441
Protein Name
Scavenger receptor class B member 1
Secondarily
Protein Name
CD36 and LIMPII analogous 1
CD36 antigen-like 1
Collagen type I receptor
thrombospondin receptor-like 1
SR-BI
Gene Name
SCARB1
Secondarily
Gene Name
CD36L1
CLA1
Sequence
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).
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Uniprot ID
Primary ID:
Q8WTV0

Secondarily ID:
F8W8N0
Q14016
Q52LZ5
Q6KFX4
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Ensembl ID
ENSG00000073060
HGNC ID
HGNC:1664
Subcellular Location
Cell membrane
Membrane
Caveola
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000148 , Huh-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0259227
 Compound Info 
5-[9-[3-(3,5-difluorophenyl)sulfanylpropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H23F2N3OS
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
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CP0389671
 Compound Info 
5-[9-[3-(6-fluoro-1H-benzimidazol-2-yl)propyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C25H24FN5O
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0470424
 Compound Info 
2-[9-[3-(4,6-dimethylpyrimidin-2-yl)oxypropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-1,3-oxazole
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C24H26N4O2
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0477003
 Compound Info 
5-[9-[3-(3,4-difluorophenoxy)propyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H23F2N3O2
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0477004
 Compound Info 
5-[9-[3-(3,5-difluorophenoxy)propyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H23F2N3O2
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0497406
 Compound Info 
5-[9-[3-(3,4-difluorophenyl)sulfanylpropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H23F2N3OS
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0497407
 Compound Info 
5-[9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C26H31N5O2
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0534135
 Compound Info 
N,N-dimethyl-3-[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1,2,3,4-tetrahydrocarbazol-9-yl]propane-1-sulfonamide
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C20H26N4O3S
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0534139
 Compound Info 
9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-6-nitro-1,2,3,4-tetrahydrocarbazole
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C23H28N4O3
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0534140
 Compound Info 
methyl 9-[3-(4,6-dimethylpyrimidin-2-yl)oxypropyl]-5,6,7,8-tetrahydrocarbazole-3-carboxylate
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C23H27N3O3
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0535743
 Compound Info 
9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-6-(3-methyl-1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H-carbazol-4-one
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C26H29N5O3
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
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CP0535744
 Compound Info 
5-[9-[3-(3,5-difluorophenoxy)-2-fluoropropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H22F3N3O2
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
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CP0542313
 Compound Info 
9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-6-(tetrazol-1-yl)-1,2,3,4-tetrahydrocarbazole
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C24H29N7O
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
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CP0542314
 Compound Info 
3-methyl-5-[9-[3-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]oxypropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-1,2,4-oxadiazole
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C24H24F3N5O2
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0571451
 Compound Info 
5-[9-[3-(4,6-dimethylpyrimidin-2-yl)oxypropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H27N5O2
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
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CP0414259
 Compound Info 
5-[9-[3-(3,5-difluorophenyl)sulfonylpropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H23F2N3O3S
  1
1
IC50 = 5 nM
 Bioactivity Info 
   TI
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CP0477002
 Compound Info 
9-[3-(3,5-difluorophenyl)sulfanylpropyl]-6-(3-methyl-1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H-carbazol-4-one
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C24H21F2N3O2S
  1
1
IC50 = 5 nM
 Bioactivity Info 
   TI
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CP0535746
 Compound Info 
3-[9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-5-methyl-1,2,4-oxadiazole
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C26H31N5O2
  1
1
IC50 = 5 nM
 Bioactivity Info 
   TI
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CP0571848
 Compound Info 
4,6-dimethoxy-N-[3-(6-methylsulfonyl-1,2,3,4-tetrahydrocarbazol-9-yl)propyl]pyrimidin-2-amine
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C22H28N4O4S
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
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CP0414258
 Compound Info 
5-[9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-6,6-difluoro-7,8-dihydro-5H-carbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C26H29F2N5O2
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0477005
 Compound Info 
9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-6-(4-propyltriazol-1-yl)-1,2,3,4-tetrahydrocarbazole
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C28H36N6O
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0523695
 Compound Info 
5-[9-[3-(3,5-difluorophenyl)sulfinylpropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H23F2N3O2S
  1
1
IC50 = 15 nM
 Bioactivity Info 
   TI
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CP0534136
 Compound Info 
2-[9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-5-methyl-1,3,4-oxadiazole
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C26H31N5O2
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0534138
 Compound Info 
9-[3-[(4,6-dimethoxypyrimidin-2-yl)amino]propyl]-5,6,7,8-tetrahydrocarbazole-3-carbonitrile
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C22H25N5O2
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0543304
 Compound Info 
9-[3-(4,6-dimethylpyrimidin-2-yl)oxypropyl]-5,6,7,8-tetrahydrocarbazole-3-carbonitrile
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C22H24N4O
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0571847
 Compound Info 
5-[9-[3-(3,5-difluorophenyl)sulfanylpropyl]-6,6-difluoro-7,8-dihydro-5H-carbazol-3-yl]-3-methyl-1,2,4-oxadiazole
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C24H21F4N3OS
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0470425
 Compound Info 
9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-6-methylsulfonyl-1,2,3,4-tetrahydrocarbazole
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C24H31N3O3S
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0389673
 Compound Info 
3-(6-cyano-1,2,3,4-tetrahydrocarbazol-9-yl)-N,N-dimethylpropane-1-sulfonamide
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C18H23N3O2S
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0534137
 Compound Info 
9-[3-(1H-benzimidazol-2-yl)propyl]-5,6,7,8-tetrahydrocarbazole-3-carbonitrile
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C23H22N4
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0535745
 Compound Info 
2-[9-[3-(4,6-dimethylpyrimidin-2-yl)oxypropyl]-5,6,7,8-tetrahydrocarbazol-3-yl]-4,5-dihydro-1,3-oxazole
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C24H28N4O2
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
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CP0535747
 Compound Info 
9-[3-(1H-benzimidazol-2-yl)propyl]-6-methylsulfonyl-1,2,3,4-tetrahydrocarbazole
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C23H25N3O2S
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0543303
 Compound Info 
9-[3-(4,6-diethylpyrimidin-2-yl)oxypropyl]-6-[4-(fluoromethyl)triazol-1-yl]-1,2,3,4-tetrahydrocarbazole
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C26H31FN6O
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
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CP0570526
 Compound Info 
9-[3-(4,6-dimethylpyrimidin-2-yl)oxypropyl]-6-methylsulfonyl-1,2,3,4-tetrahydrocarbazole
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C22H27N3O3S
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0542315
 Compound Info 
N,N-dimethyl-3-(6-methylsulfonyl-1,2,3,4-tetrahydrocarbazol-9-yl)propane-1-sulfonamide
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C18H26N2O4S2
  1
1
IC50 = 500 nM
 Bioactivity Info 
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Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Scavenger receptor class B member 1 (SCARB1) )
Target Type Literature-reported Target