General Information of the Protein
Protein ID
PT06345
Protein Name
Solute carrier family 15 member 2
Secondarily
Protein Name
Kidney H(+)/peptide cotransporter
Oligopeptide transporter
kidney isoform
Peptide transporter 2
Gene Name
SLC15A2
Secondarily
Gene Name
Pept2
Sequence
MNPFQKNESKETLFSPVSTEEMLPRPPSPPKKSPPKIFGSSYPVSIAFIVVNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVFKSLGAIPILGGKMLHTILSLVGLSLIALGTGGIKPCVAAFGGDQFEEEHAEARTRYFSVFYLAINAGSLISTFITPMLRGDVKCFGQDCYALAFGVPGLLMVLALVVFAMGSKMYRKPPPEGNIVAQVIKCIWFALCNRFRNRSGDLPKRQHWLDWAAEKYPKHLIADVKALTRVLFLYIPLPMFWALLDQQGSRWTLQANKMNGDLGFFVLQPDQMQVLNPFLVLIFIPLFDLVIYRLISKCRINFSSLRKMAVGMILACLAFAVAALVETKINGMIHPQPASQEIFLQVLNLADGDVKVTVLGSRNNSLLVESVSSFQNTTHYSKLHLEAKSQDLHFHLKYNSLSVHNDHSVEEKNCYQLLIHQDGESISSMLVKDTGIKPANGMAAIRFINTLHKDLNISLDTDAPLSVGKDYGVSAYRTVLRGKYPAVHCETEDKVFSLDLGQLDFGTTYLFVITNITSQGLQAWKAEDIPVNKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLVVAQFSGLAQWAEFVLFSCLLLVVCLIFSVMAYYYVPLKSEDTREATDKQIPAVQGNMINLETKNTRL
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC15 family of peptide transporters
Function
Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:8639691). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (PubMed:8639691). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate. Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (By similarity). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:15056281). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).
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Uniprot ID
Q63424
Subcellular Location
Apical cell membrane
Cytoplasmic vesicle
Phagosome membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000009 , LLC-PK1
Compound ID Compound Name Compound Formula
CP0178740
BL-S578
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C16H17N3O5S
 1
1
Ki = 3000 nM
   TI
   LI
   LO
   TS
CP0133817
(S)-2-(2-Amino-acetylamino)-4-methyl-pentanoic acid
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C8H16N2O3
 1
1
Ki = 6000 nM
   TI
   LI
   LO
   TS
CP0228451
((S)-2-Amino-3-phenyl-propionylamino)-acetic acid
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C11H14N2O3
 1
1
Ki = 7000 nM
   TI
   LI
   LO
   TS
CP0233448
(S)-2-(2-Amino-acetylamino)-3-(1H-indol-3-yl)-propionic acid
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C13H15N3O3
 1
1
Ki = 7000 nM
   TI
   LI
   LO
   TS
CP0056548
(S)-2-(2-Amino-acetylamino)-3-phenyl-propionic acid
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C11H14N2O3
 1
1
Ki = 8000 nM
   TI
   LI
   LO
   TS
CP0354596
(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
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C17H25N3O5
 1
1
Ki = 8000 nM
   TI
   LI
   LO
   TS
CP0102052
(S)-2-(2-Amino-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid
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C11H14N2O4
 1
1
Ki = 14000 nM
   TI
   LI
   LO
   TS
CP0288946
CHEBI:74394
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C8H16N2O3S
 1
1
Ki = 17000 nM
   TI
   LI
   LO
   TS
CP0037780
(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
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C16H24N2O4
 1
1
Ki = 18000 nM
   TI
   LI
   LO
   TS
CP0219242
((S)-2,6-Diamino-hexanoylamino)-acetic acid
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C8H17N3O3
 1
1
Ki = 21000 nM
   TI
   LI
   LO
   TS
CP0354595
CHEBI:73888
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C6H11N3O4
 1
1
Ki = 22000 nM
   TI
   LI
   LO
   TS
CP0049376
CICLACILLIN
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C15H23N3O4S
 1
1
Ki = 27000 nM
   TI
   LI
   LO
   TS
CP0233435
CHEBI:73905
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C13H17N3O4
 1
1
Ki = 29000 nM
   TI
   LI
   LO
   TS
CP0275781
(2S)-2-amino-N-(4-nitrophenyl)propanamide
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C9H11N3O3
 1
1
Ki = 29000 nM
   TI
   LI
   LO
   TS
CP0310662
(S)-2-(2-Amino-acetylamino)-3-(3H-imidazol-4-yl)-propionic acid
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C8H12N4O3
 1
1
Ki = 39000 nM
   TI
   LI
   LO
   TS
CP0213590
Substrate analogue, 16
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C4H8N2O3
 1
1
Ki = 42000 nM
   TI
   LI
   LO
   TS
CP0045560
(S)-3-Amino-N-carboxymethyl-succinamic acid
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C6H10N2O5
 1
1
Ki = 46000 nM
   TI
   LI
   LO
   TS
CP0271018
Anspor
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C16H19N3O4S
 1
1
Ki = 47000 nM
   TI
   LI
   LO
   TS
CP0099743
(6R,7R)-7-((R)-2-Amino-2-phenyl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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C16H17N3O4S
 1
1
Ki = 49000 nM
   TI
   LI
   LO
   TS
CP0219176
(S)-2-(2-Amino-acetylamino)-succinic acid
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C6H10N2O5
 1
1
Ki = 60000 nM
   TI
   LI
   LO
   TS
CP0119429
CHEBI:15727
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C9H14N4O3
 1
1
Ki = 66000 nM
   TI
   LI
   LO
   TS
CP0448888
(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoic acid
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C12H26N4O3
 1
1
Ki = 96000 nM
   TI
   LI
   LO
   TS
CP0161781
2-(2-amino-N-methylacetamido)acetic acid
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C5H10N2O3
 1
1
Km = 110000 nM
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05412 Solute carrier family 15 member 2 Homo sapiens, Human