General Information of the Protein
Protein ID
PT05412
Protein Name
Solute carrier family 15 member 2
Secondarily
Protein Name
Kidney H(+)/peptide cotransporter
Oligopeptide transporter
kidney isoform
Peptide transporter 2
Gene Name
SLC15A2
Secondarily
Gene Name
PEPT2
Sequence
MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGLVQWAEFILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC15 family of peptide transporters
Function
Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661, PubMed:16434549). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed:7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:20406817).
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Uniprot ID
Primary ID:
Q16348

Secondarily ID:
A8K1A5
B4E2A7
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HGNC ID
HGNC:10921
Subcellular Location
Apical cell membrane
Cytoplasmic vesicle
Phagosome membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000017 , HeLa
Compound ID Compound Name Compound Formula
CP0309523
(2S)-2-{[(2S)-2-aminopropanoyl]amino}propanoic acid
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C6H12N2O3
 1
1
Ki = 6000 nM
   TI
   LI
   LO
   TS
CP0392794
(S)-6-Amino-2-((S)-2-amino-3-carboxy-propionylamino)-hexanoic acid
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C10H19N3O5
 1
1
Ki = 8000 nM
   TI
   LI
   LO
   TS
CP0394971
(S)-6-Amino-2-((S)-2-amino-propionylamino)-hexanoic acid
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C9H19N3O3
 1
1
Ki = 11000 nM
   TI
   LI
   LO
   TS
CP0150172
Ala-Asp
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C7H12N2O5
 1
1
Ki = 18000 nM
   TI
   LI
   LO
   TS
CP0334829
(S)-2-((S)-2,6-Diamino-hexanoylamino)-propionic acid
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C9H19N3O3
 1
1
Ki = 23000 nM
   TI
   LI
   LO
   TS
CP0161781
2-(2-amino-N-methylacetamido)acetic acid
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C5H10N2O3
 1
1
Km = 74000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Solute carrier family 15 member 2 (SLC15A2) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06345 Solute carrier family 15 member 2 Rattus norvegicus, Rat