General Information of the Protein
Protein ID
PT06097
Protein Name
ATP-sensitive inward rectifier potassium channel 11
Secondarily
Protein Name
IKATP
Inward rectifier K(+) channel Kir6.2
Potassium channel
inwardly rectifying subfamily J member 11
Gene Name
KCNJ11
Sequence
MLSRKGIIPEEYVLTRLAEDPAKPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Inwardly rectifying potassium channel
Function
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
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Uniprot ID
Primary ID:
Q14654

Secondarily ID:
B4DWI4
E9PNK0
Q2M1H7
Q58EX3
Q8IW96
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Ensembl ID
ENSG00000187486
HGNC ID
HGNC:6257
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000041 , LTK-
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0380895
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]furan-2-carboxamide
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C18H11F6NO3
  1
1
EC50 = 9 nM
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CP0502158
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]thiophene-2-carboxamide
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C18H11F6NO2S
  1
1
EC50 = 12 nM
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CP0510964
 Compound Info 
3-Cyano-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C21H12F6N2O2
  1
1
EC50 = 12 nM
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CP0521872
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]propanamide
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C16H13F6NO2
  1
1
EC50 = 15 nM
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CP0514200
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]acetamide
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C15H11F6NO2
  1
1
EC50 = 18 nM
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CP0509225
 Compound Info 
3-Methyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C21H15F6NO2
  1
1
EC50 = 23 nM
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CP0380906
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]-1,3-oxazole-5-carboxamide
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C17H10F6N2O3
  1
1
EC50 = 24 nM
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CP0417241
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]benzamide
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C20H13F6NO2
  1
1
EC50 = 44 nM
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CP0501952
 Compound Info 
3-Fluoro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12F7NO2
  1
1
EC50 = 44 nM
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CP0496094
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]cyclobutanecarboxamide
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C18H15F6NO2
  1
1
EC50 = 45 nM
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CP0506673
 Compound Info 
3-Methyl-but-2-enoic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
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C18H15F6NO2
  1
1
EC50 = 46 nM
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CP0493005
 Compound Info 
4-Bromo-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12BrF6NO2
  1
1
EC50 = 47 nM
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CP0495424
 Compound Info 
4-Methyl-pentanoic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
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C19H19F6NO2
  1
1
EC50 = 49 nM
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CP0510965
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]pyridine-3-carboxamide
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C19H12F6N2O2
  1
1
EC50 = 60 nM
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CP0458850
 Compound Info 
4-Fluoro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12F7NO2
  1
1
EC50 = 70 nM
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CP0460238
 Compound Info 
But-2-enoic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
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C17H13F6NO2
  1
1
EC50 = 72 nM
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CP0374623
 Compound Info 
4-Methyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C21H15F6NO2
  1
1
EC50 = 76 nM
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CP0535068
 Compound Info 
3-Bromo-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12BrF6NO2
  1
1
EC50 = 80 nM
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CP0548981
 Compound Info 
2-Cyclopentyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-acetamide
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C20H19F6NO2
  1
1
EC50 = 81 nM
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CP0521874
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]-3-(trifluoromethyl)benzamide
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C21H12F9NO2
  1
1
EC50 = 84 nM
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CP0448101
 Compound Info 
3-Chloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12ClF6NO2
  1
1
EC50 = 98 nM
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CP0452807
 Compound Info 
3-Nitro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12F6N2O4
  1
1
EC50 = 117 nM
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CP0505918
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]butanamide
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C17H15F6NO2
  1
1
EC50 = 131 nM
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CP0458843
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-hydroxynaphthalen-1-yl]acetamide
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C15H11F6NO3
  1
1
EC50 = 137 nM
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CP0453134
 Compound Info 
4-Iodo-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12F6INO2
  1
1
EC50 = 154 nM
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CP0521873
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]-4-(trifluoromethyl)benzamide
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C21H12F9NO2
  1
1
EC50 = 160 nM
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CP0525378
 Compound Info 
3-Methoxy-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C21H15F6NO3
  1
1
EC50 = 185 nM
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CP0376299
 Compound Info 
3,4-Dichloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H11Cl2F6NO2
  1
1
EC50 = 194 nM
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CP0480513
 Compound Info 
2-Methoxy-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-acetamide
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C16H13F6NO3
  1
1
EC50 = 213 nM
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CP0509224
 Compound Info 
1-(4-Chloro-phenyl)-3-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-urea
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C20H13ClF6N2O2
  1
1
EC50 = 276 nM
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CP0527499
 Compound Info 
3,5-Dichloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H11Cl2F6NO2
  1
1
EC50 = 306 nM
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CP0496159
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]quinoxaline-2-carboxamide
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C22H13F6N3O2
  1
1
EC50 = 317 nM
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CP0507635
 Compound Info 
4-Methoxy-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C21H15F6NO3
  1
1
EC50 = 417 nM
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CP0505985
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]cyclopentanecarboxamide
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C19H17F6NO2
  1
1
EC50 = 495 nM
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CP0405334
 Compound Info 
4-Chloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12ClF6NO2
  1
1
EC50 = 570 nM
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CP0507153
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]cyclopropanecarboxamide
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C17H13F6NO2
  1
1
EC50 = 751 nM
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CP0419388
 Compound Info 
propan-2-yl N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]carbamate
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C17H15F6NO3
  1
1
EC50 = 1160 nM
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CP0534546
 Compound Info 
3-Phenyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-propionamide
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C22H17F6NO2
  1
1
EC50 = 1750 nM
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CP0502202
 Compound Info 
2-Chloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H12ClF6NO2
  1
1
EC50 = 2040 nM
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CP0509972
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-6-hydroxynaphthalen-1-yl]acetamide
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C15H11F6NO3
  1
1
EC50 = 2220 nM
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CP0493006
 Compound Info 
2-Ethyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-butyramide
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C19H19F6NO2
  1
1
EC50 = 4340 nM
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CP0423944
 Compound Info 
1-(6-Chloro-hexyl)-3-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-urea
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C20H21ClF6N2O2
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1
EC50 = 4840 nM
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CP0537899
 Compound Info 
N-[4-bromo-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]acetamide
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C15H10BrF6NO2
  1
1
EC50 = 5310 nM
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CP0460152
 Compound Info 
2-Methyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C21H15F6NO2
  1
1
EC50 = 5550 nM
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CP0502244
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]-2-methylpropanamide
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C17H15F6NO2
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1
EC50 = 6630 nM
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CP0376304
 Compound Info 
Biphenyl-4-carboxylic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
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C26H17F6NO2
  1
1
EC50 > 10000 nM
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CP0405041
 Compound Info 
N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]-4-(trifluoromethoxy)benzamide
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C21H12F9NO3
  1
1
EC50 > 10000 nM
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CP0431077
 Compound Info 
2-Methyl-pentanoic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
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C19H19F6NO2
  1
1
EC50 > 10000 nM
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CP0441629
 Compound Info 
2,3-Dichloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-benzamide
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C20H11Cl2F6NO2
  1
1
EC50 > 10000 nM
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CP0504104
 Compound Info 
Benzo[b]thiophene-2-carboxylic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
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C22H13F6NO2S
  1
1
EC50 > 10000 nM
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Cell Line ID: CL000309 , NCTC clone 929
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Inward rectifier potassium channel Kir6.2 (KCNJ11) )
Target Type Literature-reported Target