General Information of the Compound
Compound ID
CP0534546
Compound Name
3-Phenyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-propionamide
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Structure
Formula
C22H17F6NO2
Molecular Weight
441.371
Canonical SMILES
OC(c1ccc2ccccc2c1NC(=O)CCc1ccccc1)(C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C22H17F6NO2/c23-21(24,25)20(31,22(26,27)28)17-12-11-15-8-4-5-9-16(15)19(17)29-18(30)13-10-14-6-2-1-3-7-14/h1-9,11-12,31H,10,13H2,(H,29,30)
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InChIKey
JSUYWDFYYXKFOZ-UHFFFAOYSA-N
Physicochemical Property
logP
5.7233
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
49.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10411024
SID: 15428637
ChEMBL ID
CHEMBL48755
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06097, ATP-sensitive inward rectifier potassium channel 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000041 LTK- Mus musculus (Mouse)  1
1
EC50 = 1750 nM
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