Protein Information

General Information of the Protein

Protein ID	PT05453
Protein Name	G-protein coupled receptor 55
Gene Name	GPR55
Sequence	MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIRAHRPSRVQLVLQDTTISRG Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Lipid-like ligand receptor (family A GPCR) > Lysophosphatidylinositol receptor
Function	G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935). Show/Hide
Uniprot ID	Primary ID: Q9Y2T6 Secondarily ID: Q8N580 Show/Hide
HGNC ID	HGNC:4511
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0552865 Compound Info	CHEMBL2387746 Show/Hide	C29H49O12P	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0849481 Compound Info	1-lysophosphatidylinositol Show/Hide	C29H49O12P	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0048192 Compound Info	2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-5-(2-methyloctan-2-yl)phenol Show/Hide	C24H40O3	1
1	EC50 = 1610 nM Bioactivity Info	TI LI LO TS
CP0003146 Compound Info	5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide Show/Hide	C22H21Cl3N4O	1
1	EC50 = 2010 nM Bioactivity Info	TI LI LO TS
CP0389155 Compound Info	(4Z)-2-[(4-bromophenyl)methylsulfanyl]-4-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-1H-imidazol-5-one Show/Hide	C24H18BrClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0389156 Compound Info	(4Z)-2-benzylsulfanyl-4-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-1H-imidazol-5-one Show/Hide	C24H19ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0389157 Compound Info	(5Z)-5-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-3-methyl-2-[(4-methylphenyl)methylsulfanyl]imidazol-4-one Show/Hide	C26H23ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0389159 Compound Info	(2Z)-2-[[3-[6-(4-chlorophenoxy)hexoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C25H27ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396299 Compound Info	(2Z)-2-[[3-[4-(4-chlorophenoxy)butoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C23H23ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396300 Compound Info	(2Z)-2-[[3-[6-(4-propan-2-ylphenoxy)hexoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C28H34N2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396303 Compound Info	(4Z)-4-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2-(2-phenylethylsulfanyl)-1H-imidazol-5-one Show/Hide	C25H21ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396304 Compound Info	(4Z)-4-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2-[(4-fluorophenyl)methylsulfanyl]-1H-imidazol-5-one Show/Hide	C24H18ClFN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396305 Compound Info	(2Z)-2-[[3-[5-(4-chlorophenoxy)pentoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C24H25ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3770 nM Bioactivity Info	TI LI LO TS
CP0396306 Compound Info	(5Z)-5-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-one Show/Hide	C19H15ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396308 Compound Info	(4Z)-4-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2-[(4-methylphenyl)methylsulfanyl]-1H-imidazol-5-one Show/Hide	C25H21ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396310 Compound Info	(2Z)-2-[[3-[3-(4-chlorophenoxy)propoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C22H21ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396311 Compound Info	(2Z)-2-[[3-[6-(4-methylphenoxy)hexoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C26H30N2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2910 nM Bioactivity Info	TI LI LO TS
CP0396331 Compound Info	(2Z)-2-[[3-[2-(4-chlorophenoxy)ethoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C21H19ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 10100 nM Bioactivity Info	TI LI LO TS
CP0396341 Compound Info	(4Z)-4-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2-[(4-chlorophenyl)methylsulfanyl]-1H-imidazol-5-one Show/Hide	C24H18Cl2N2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396346 Compound Info	(5Z)-5-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Show/Hide	C17H12ClNO3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0408491 Compound Info	(5Z)-5-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one Show/Hide	C17H12ClNO2S2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0408540 Compound Info	(6Z)-6-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-one Show/Hide	C19H15ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0408541 Compound Info	(2Z)-2-[[3-[(4-fluorophenyl)methoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C20H17FN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 4220 nM Bioactivity Info	TI LI LO TS
CP0429381 Compound Info	(5Z)-5-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-3-methyl-2-methylsulfanylimidazol-4-one Show/Hide	C19H17ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0429382 Compound Info	(2Z)-2-[[3-[7-(4-chlorophenoxy)heptoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C26H29ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0429401 Compound Info	(2Z)-2-[[3-[6-(4-ethylphenoxy)hexoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C27H32N2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0429402 Compound Info	(5Z)-5-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2-imino-1-methylimidazolidin-4-one Show/Hide	C18H16ClN3O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0429406 Compound Info	(2Z)-2-[[3-(2-phenylethoxy)phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C21H20N2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 29300 nM Bioactivity Info	TI LI LO TS
CP0429408 Compound Info	(2Z)-2-[[3-[6-(2-chlorophenoxy)hexoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C25H27ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3410 nM Bioactivity Info	TI LI LO TS
CP0432722 Compound Info	(2Z)-2-[[3-[(4-methylphenyl)methoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C21H20N2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 9450 nM Bioactivity Info	TI LI LO TS
CP0445929 Compound Info	(2Z)-2-[[3-[6-(2,6-dimethylphenoxy)hexoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C27H32N2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0470826 Compound Info	(2Z)-2-[[3-[(4-bromophenyl)methoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C20H17BrN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 45800 nM Bioactivity Info	TI LI LO TS
CP0471723 Compound Info	(2Z)-2-[[3-[8-(4-chlorophenoxy)octoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C27H31ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0471783 Compound Info	(5Z)-5-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2-sulfanylideneimidazolidin-4-one Show/Hide	C17H13ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 32400 nM Bioactivity Info	TI LI LO TS
CP0471793 Compound Info	(4Z)-4-[[3-[(4-chlorophenyl)methoxy]phenyl]methylidene]-2-methylsulfanyl-1H-imidazol-5-one Show/Hide	C18H15ClN2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0471794 Compound Info	(2Z)-2-[[3-(3-phenylpropoxy)phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C22H22N2O2S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 6040 nM Bioactivity Info	TI LI LO TS
CP0471795 Compound Info	(2Z)-2-[[3-[6-(3-chlorophenoxy)hexoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one Show/Hide	C25H27ClN2O3S	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0045801 Compound Info	(10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C21H30O2	3
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 14200 nM Bioactivity Info	TI LI LO TS
3	IC50 = 14200 nM Bioactivity Info	TI LI LO TS
CP0085151 Compound Info	9-(4-chlorophenethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione Show/Hide	C18H20ClN5O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0123281 Compound Info	9-(4-chlorobenzyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione Show/Hide	C17H18ClN5O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0378535 Compound Info	9-(2-(1H-indol-3-yl)ethyl)-1,3-dipropyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione Show/Hide	C24H30N6O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0378537 Compound Info	9-(4-methoxyphenethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione Show/Hide	C19H23N5O3	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0392989 Compound Info	9-(2-(1H-indol-3-yl)ethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione Show/Hide	C20H22N6O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0422929 Compound Info	9-ethyl-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C12H17N5O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0422930 Compound Info	6-(4-hydroxyphenyl)-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione Show/Hide	C15H15N5O3	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0422931 Compound Info	10-[2-(1H-indol-3-yl)ethyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione Show/Hide	C21H24N6O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0422932 Compound Info	6-[2-(1H-indol-3-yl)ethyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione Show/Hide	C19H20N6O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0422933 Compound Info	9-(3,4-dimethoxyphenethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione Show/Hide	C20H25N5O4	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0427936 Compound Info	1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione Show/Hide	C18H21N5O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0466255 Compound Info	4-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol Show/Hide	C21H30O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0466257 Compound Info	1,3-dimethyl-9-pentyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C15H23N5O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0466263 Compound Info	9-(2-methoxyethyl)-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C13H19N5O3	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0478985 Compound Info	9-butyl-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C14H21N5O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0507518 Compound Info	9-[2-(diethylamino)ethyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C16H26N6O2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0659893 Compound Info	(Z)-2-(3-(4-chlorobenzyloxy)benzylidene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C21H19ClN2O2S	1
1	EC50 = 10700 nM Bioactivity Info	TI LI LO TS
CP0393612 Compound Info	5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-(2-methylnonan-2-yl)chromen-2-one Show/Hide	C26H32O4	1
1	IC50 = 113 nM Bioactivity Info	TI LI LO TS
CP0397664 Compound Info	5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-(2-methyloctan-2-yl)chromen-2-one Show/Hide	C25H30O4	1
1	IC50 = 261 nM Bioactivity Info	TI LI LO TS
CP0393601 Compound Info	3-benzyl-5-hydroxy-7-(2-methyloctan-2-yl)chromen-2-one Show/Hide	C25H30O3	1
1	IC50 = 358 nM Bioactivity Info	TI LI LO TS
CP0393600 Compound Info	7-(1-butylcyclopentyl)-5-hydroxy-3-[(2-hydroxyphenyl)methyl]chromen-2-one Show/Hide	C25H28O4	1
1	IC50 = 854 nM Bioactivity Info	TI LI LO TS
CP0387822 Compound Info	7-(1-butylcyclohexyl)-5-hydroxy-3-[(2-hydroxyphenyl)methyl]chromen-2-one Show/Hide	C26H30O4	1
1	IC50 = 961 nM Bioactivity Info	TI LI LO TS
CP0375172 Compound Info	6-methoxy-3-[(2-methoxyphenyl)methyl]-5,7,8-trimethylchromen-2-one Show/Hide	C21H22O4	1
1	IC50 = 981 nM Bioactivity Info	TI LI LO TS
CP0393584 Compound Info	3-[(2-hydroxyphenyl)methyl]-8-methyl-5-propan-2-ylchromen-2-one Show/Hide	C20H20O3	1
1	IC50 = 1770 nM Bioactivity Info	TI LI LO TS
CP0456827 Compound Info	2-Benzylbenzo[f]chromen-3-one Show/Hide	C20H14O2	1
1	IC50 = 2810 nM Bioactivity Info	TI LI LO TS
CP0692927 Compound Info	(Z)-2-(2,3-Difluorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b]-[1,3]thiazin-3(5H)-one Show/Hide	C13H10F2N2OS	1
1	IC50 = 3150 nM Bioactivity Info	TI LI LO TS
CP0374913 Compound Info	5-methoxy-3-[(3-methoxyphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C23H26O4	1
1	IC50 = 3230 nM Bioactivity Info	TI LI LO TS
CP0374915 Compound Info	3-[(4-chlorophenyl)methyl]-5-methoxy-7-pentylchromen-2-one Show/Hide	C22H23ClO3	1
1	IC50 = 3290 nM Bioactivity Info	TI LI LO TS
CP0393614 Compound Info	5-Isopropyl-3,8-dimethylchromen-2-one Show/Hide	C14H16O2	1
1	IC50 = 3450 nM Bioactivity Info	TI LI LO TS
CP0849169 Compound Info	(Z)-2-(2,4-Difluorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b]-[1,3]thiazin-3(5H)-one Show/Hide	C13H10F2N2OS	1
1	IC50 = 3460 nM Bioactivity Info	TI LI LO TS
CP0393585 Compound Info	3-[(4-bromophenyl)methyl]-5-methoxy-7-pentylchromen-2-one Show/Hide	C22H23BrO3	1
1	IC50 = 3760 nM Bioactivity Info	TI LI LO TS
CP0391309 Compound Info	7-bromo-5-methoxy-3-[(3-methoxyphenyl)methyl]chromen-2-one Show/Hide	C18H15BrO4	1
1	IC50 = 3990 nM Bioactivity Info	TI LI LO TS
CP0387826 Compound Info	5-methoxy-3-[(2-methylphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C23H26O3	1
1	IC50 = 5080 nM Bioactivity Info	TI LI LO TS
CP0659958 Compound Info	(Z)-2-(2-chlorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C13H11ClN2OS	1
1	IC50 = 5090 nM Bioactivity Info	TI LI LO TS
CP0375125 Compound Info	6-hydroxy-5,7,8-trimethyl-3-[(2-methylphenyl)methyl]chromen-2-one Show/Hide	C20H20O3	1
1	IC50 = 5160 nM Bioactivity Info	TI LI LO TS
CP0375124 Compound Info	3-Benzyl-5-isopropyl-8-methylchromen-2-one Show/Hide	C20H20O2	1
1	IC50 = 5330 nM Bioactivity Info	TI LI LO TS
CP0905395 Compound Info	(Z)-2-(2-Fluorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b]-[1,3]thiazin-3(5H)-one Show/Hide	C13H11FN2OS	1
1	IC50 = 5560 nM Bioactivity Info	TI LI LO TS
CP0375166 Compound Info	3-[(2-methoxyphenyl)methyl]-5-methyl-8-propan-2-ylchromen-2-one Show/Hide	C21H22O3	1
1	IC50 = 5700 nM Bioactivity Info	TI LI LO TS
CP0381005 Compound Info	6-bromo-8-[(6-methoxypyridine-3-carbonyl)amino]-4-oxochromene-2-carboxylic acid Show/Hide	C17H11BrN2O6	1
1	IC50 = 6200 nM Bioactivity Info	TI LI LO TS
CP0387823 Compound Info	5-methoxy-3-[(2-methoxyphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C23H26O4	1
1	IC50 = 6350 nM Bioactivity Info	TI LI LO TS
CP0393582 Compound Info	3-Benzyl-5-methoxy-7-methylchromen-2-one Show/Hide	C18H16O3	1
1	IC50 = 6740 nM Bioactivity Info	TI LI LO TS
CP0859468 Compound Info	(Z)-2-(2,4-Dichlorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b]-[1,3]-thiazin-3(5H)-one Show/Hide	C13H10Cl2N2OS	1
1	IC50 = 6760 nM Bioactivity Info	TI LI LO TS
CP0858888 Compound Info	(Z)-2-(2,3-dichlorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C13H10Cl2N2OS	1
1	IC50 = 6910 nM Bioactivity Info	TI LI LO TS
CP0393599 Compound Info	3-[(2-methoxyphenyl)methyl]-5,8-dimethylchromen-2-one Show/Hide	C19H18O3	1
1	IC50 = 7140 nM Bioactivity Info	TI LI LO TS
CP0393598 Compound Info	6-methoxy-5,7,8-trimethyl-3-[(2-methylphenyl)methyl]chromen-2-one Show/Hide	C21H22O3	1
1	IC50 = 7690 nM Bioactivity Info	TI LI LO TS
CP0380115 Compound Info	6-bromo-8-[(5-methoxypyridine-2-carbonyl)amino]-4-oxochromene-2-carboxylic acid Show/Hide	C17H11BrN2O6	1
1	IC50 = 8920 nM Bioactivity Info	TI LI LO TS
CP0375169 Compound Info	3-[(2-chlorophenyl)methyl]-5-methoxy-7-pentylchromen-2-one Show/Hide	C22H23ClO3	1
1	IC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0375117 Compound Info	3-benzyl-6-hydroxy-5,7,8-trimethylchromen-2-one Show/Hide	C19H18O3	1
1	IC50 = 9320 nM Bioactivity Info	TI LI LO TS
CP0659851 Compound Info	(Z)-2-(2,4-dimethoxybenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C15H16N2O3S	1
1	IC50 = 9770 nM Bioactivity Info	TI LI LO TS
CP0351998 Compound Info	3-benzyl-5-hydroxychromen-2-one Show/Hide	C16H12O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0374924 Compound Info	3-benzyl-8-methoxychromen-2-one Show/Hide	C17H14O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0375105 Compound Info	7-(1-butylcyclohexyl)-5-methoxy-3-[(2-methoxyphenyl)methyl]chromen-2-one Show/Hide	C28H34O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0375106 Compound Info	3-[(4-fluorophenyl)methyl]-5-methoxy-7-pentylchromen-2-one Show/Hide	C22H23FO3	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0375127 Compound Info	3-benzyl-5-methoxy-7-(2-methyloctan-2-yl)chromen-2-one Show/Hide	C26H32O3	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0375165 Compound Info	5-methoxy-3-[(2-methoxyphenyl)methyl]-7-(2-methylnonan-2-yl)chromen-2-one Show/Hide	C28H36O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0375174 Compound Info	5-methoxy-3-[(3-methoxyphenyl)methyl]chromen-2-one Show/Hide	C18H16O4	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0376853 Compound Info	7-(1-butylcyclopentyl)-5-methoxy-3-[(2-methoxyphenyl)methyl]chromen-2-one Show/Hide	C27H32O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0376854 Compound Info	5-hydroxy-3-[(2-methylphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C22H24O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0376857 Compound Info	5-methoxy-3-[(3-methylphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C23H26O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0377269 Compound Info	6-Methoxy-3-methylchromen-2-one Show/Hide	C11H10O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0380662 Compound Info	2-Methylbenzo[f]chromen-3-one Show/Hide	C14H10O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0387824 Compound Info	5-methoxy-3-[(2-methoxyphenyl)methyl]-7-(2-methyloctan-2-yl)chromen-2-one Show/Hide	C27H34O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0391310 Compound Info	5-hydroxy-7-methyl-3-[(2-methylphenyl)methyl]chromen-2-one Show/Hide	C18H16O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0391311 Compound Info	5-hydroxy-3-[(3-methylphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C22H24O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0391312 Compound Info	3-benzyl-5-hydroxy-7-pentylchromen-2-one Show/Hide	C21H22O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0393602 Compound Info	3-[(2-chlorophenyl)methyl]-5-hydroxy-7-pentylchromen-2-one Show/Hide	C21H21ClO3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0393607 Compound Info	5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C21H22O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0393608 Compound Info	7-methoxy-3-methylchromen-2-one Show/Hide	C11H10O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0393609 Compound Info	7-(hydroxymethyl)-5-methoxy-3-[(3-methoxyphenyl)methyl]chromen-2-one Show/Hide	C19H18O5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0393610 Compound Info	5-hydroxy-7-methyl-3-[(4-methylphenyl)methyl]chromen-2-one Show/Hide	C18H16O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0393611 Compound Info	3-Benzylchromen-2-one Show/Hide	C16H12O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0393613 Compound Info	3-Benzyl-7-methoxychromen-2-one Show/Hide	C17H14O3	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0394935 Compound Info	7-(bromomethyl)-5-methoxy-3-[(3-methoxyphenyl)methyl]chromen-2-one Show/Hide	C19H17BrO4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0395520 Compound Info	3-Benzyl-8-bromo-5-methoxychromen-2-one Show/Hide	C17H13BrO3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396474 Compound Info	3-[(3-chlorophenyl)methyl]-5-methoxy-7-pentylchromen-2-one Show/Hide	C22H23ClO3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396475 Compound Info	8-bromo-6-chloro-3-methylchromen-2-one Show/Hide	C10H6BrClO2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396592 Compound Info	3-[(3-chlorophenyl)methyl]-5-hydroxy-7-pentylchromen-2-one Show/Hide	C21H21ClO3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396721 Compound Info	6-Iodo-3-methyl-chromen-2-one Show/Hide	C10H7IO2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0397666 Compound Info	3-benzyl-5-methoxy-7-pentylchromen-2-one Show/Hide	C22H24O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0431359 Compound Info	3-Benzyl-6-iodochromen-2-one Show/Hide	C16H11IO2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0433057 Compound Info	3-Benzyl-6-methoxychromen-2-one Show/Hide	C17H14O3	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0446290 Compound Info	5-methoxy-3-[(4-methoxy-3,5-dimethylphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C25H30O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0454966 Compound Info	8-Methoxy-3-methylchromen-2-one Show/Hide	C11H10O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0454967 Compound Info	3-Benzyl-5-methoxychromen-2-one Show/Hide	C17H14O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0463757 Compound Info	6-Bromo-8-methoxy-3-methylchromen-2-one Show/Hide	C11H9BrO3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0125632 Compound Info	((5Z,8Z)-Icosa-5,8,11,14-tetraenoylamino)-acetic acid Show/Hide	C22H35NO3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0659892 Compound Info	(Z)-2-(3-(4-Chlorobenzyloxy)benzylidene)-6,7-dihydro-2H-imidazo-[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C20H17ClN2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0677588 Compound Info	(Z)-2-benzylidene-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C13H12N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0709769 Compound Info	(Z)-2-(3-(3-Chlorobenzyloxy)benzylidene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C21H19ClN2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849166 Compound Info	(Z)-2-(4-bromobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C13H11BrN2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849167 Compound Info	(Z)-2-(3-(Benzyloxy)benzylidene)-6,7-dihydro-2H-imidazo-[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C20H18N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849168 Compound Info	(Z)-2-(4-methoxybenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C14H14N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849218 Compound Info	(Z)-2-(3-(2,4-dichlorobenzyloxy)benzylidene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C21H18Cl2N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849399 Compound Info	6,6-diphenyl-2,3-dihydroimidazo[2,1-b]thiazol-5(6H)-one Show/Hide	C17H14N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849409 Compound Info	(Z)-2-(2-methoxybenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C14H14N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849467 Compound Info	(Z)-2-(3-phenoxybenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C19H16N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849468 Compound Info	(Z)-2-(3,4-dimethoxybenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C15H16N2O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849470 Compound Info	(Z)-2-(3-nitrobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C13H11N3O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849472 Compound Info	(Z)-2-(3-phenylallylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C15H14N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0849480 Compound Info	(Z)-3-(3-phenylallylidene)-3,5,6,7-tetrahydro-2H-imidazo[2,1-b][1,3]thiazin-2-one Show/Hide	C15H14N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0850010 Compound Info	(Z)-2-(2,6-Dichlorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b]-[1,3]thiazin-3(5H)-one Show/Hide	C13H10Cl2N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0858889 Compound Info	(Z)-2-(4-isopropylbenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C16H18N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859207 Compound Info	(Z)-2-(4-chlorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C13H11ClN2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859208 Compound Info	(Z)-ethyl 2-(3-((3-oxo-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-2(3H)-ylidene)methyl)phenoxy)acetate Show/Hide	C18H20N2O4S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859209 Compound Info	(Z)-2-(3-(2,4-Dichlorobenzyloxy)benzylidene)-6,7-dihydro-2Himidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C20H16Cl2N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859210 Compound Info	2,2-diphenyl-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C19H18N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859211 Compound Info	ethyl 5-oxo-6,6-diphenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole-2-carboxylate Show/Hide	C20H18N2O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859212 Compound Info	2,2-diphenyl-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C18H16N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859457 Compound Info	(Z)-2-(3-chlorobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C13H11ClN2OS	1
1	IC50 >= 10000 nM Bioactivity Info	TI LI LO TS
CP0859466 Compound Info	(Z)-3-((3-Oxo-6,7-dihydro-3H-imidazo[2,1-b][1,3]thiazin-2(5H)-ylidene)methyl)phenyl 4-chloro-benzoate Show/Hide	C20H15ClN2O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859481 Compound Info	(Z)-2-(biphenyl-4-ylmethylene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C20H18N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0859491 Compound Info	3,3-diphenyl-3,5,6,7-tetrahydro-2H-imidazo[2,1-b][1,3]thiazin-2-one Show/Hide	C18H16N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0866547 Compound Info	ethyl 6-oxo-5,5-diphenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole-2-carboxylate Show/Hide	C20H18N2O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0866629 Compound Info	3,3-diphenyl-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-2(3H)-one Show/Hide	C19H18N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0866766 Compound Info	5,5-diphenyl-2,3-dihydroimidazo[2,1-b]thiazol-6(5H)-one Show/Hide	C17H14N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0866767 Compound Info	(Z)-2-(1-phenylethylidene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C15H16N2OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0867263 Compound Info	(Z)-2-(4-nitrobenzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C13H11N3O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0868782 Compound Info	(Z)-2-(3-(4-Fluorobenzyloxy)benzylidene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C21H19FN2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0868783 Compound Info	(Z)-2-(4-(dimethylamino)benzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C15H17N3OS	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0877023 Compound Info	(Z)-2-(3-(2-Chlorobenzyloxy)benzylidene)-6,7-dihydro-2H-imidazo-[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C20H17ClN2O2S	1
1	IC50 >= 10000 nM Bioactivity Info	TI LI LO TS
CP0881784 Compound Info	(Z)-2-(3-phenoxybenzylidene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C20H18N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0893067 Compound Info	(Z)-3-((3-oxo-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-2(3H)-ylidene)methyl)phenyl 4-methylbenzoate Show/Hide	C22H20N2O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0893073 Compound Info	(Z)-3-((3-Oxo-6,7-dihydro-3H-imidazo[2,1-b][1,3]thiazin-2(5H)-ylidene)methyl)phenyl benzoate Show/Hide	C20H16N2O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0898591 Compound Info	(Z)-2-(3-(2-Chlorobenzyloxy)benzylidene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C21H19ClN2O2S	1
1	IC50 >= 10000 nM Bioactivity Info	TI LI LO TS
CP0900469 Compound Info	(Z)-2-(3-(Benzyloxy)benzylidene)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3(2H)-one Show/Hide	C21H20N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0375171 Compound Info	3-[(4-fluorophenyl)methyl]-6-hydroxy-5,7,8-trimethylchromen-2-one Show/Hide	C19H17FO3	1
1	IC50 = 10300 nM Bioactivity Info	TI LI LO TS
CP0375170 Compound Info	5-hydroxy-3-[(3-hydroxyphenyl)methyl]-7-pentylchromen-2-one Show/Hide	C21H22O4	1
1	IC50 = 10600 nM Bioactivity Info	TI LI LO TS
CP0868197 Compound Info	(Z)-2-(3-(3,4-Dichlorobenzyloxy)benzylidene)-6,7-dihydro-2Himidazo[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C20H16Cl2N2O2S	1
1	IC50 = 11800 nM Bioactivity Info	TI LI LO TS
CP0409866 Compound Info	3-benzyl-6-methoxy-5,7,8-trimethylchromen-2-one Show/Hide	C20H20O3	1
1	IC50 = 12800 nM Bioactivity Info	TI LI LO TS
CP0394936 Compound Info	3-[(4-fluorophenyl)methyl]-6-methoxy-5,7,8-trimethylchromen-2-one Show/Hide	C20H19FO3	1
1	IC50 = 13500 nM Bioactivity Info	TI LI LO TS
CP0916683 Compound Info	(Z)-2-(2,3-Dimethoxybenzylidene)-6,7-dihydro-2H-imidazo-[2,1-b][1,3]thiazin-3(5H)-one Show/Hide	C15H16N2O3S	1
1	IC50 = 16400 nM Bioactivity Info	TI LI LO TS
CP0389119 Compound Info	6-bromo-8-[(4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid Show/Hide	C18H12BrNO6	1
1	IC50 = 21700 nM Bioactivity Info	TI LI LO TS
CP0395599 Compound Info	6-bromo-8-[(2-chloro-4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid Show/Hide	C18H11BrClNO6	1
1	IC50 = 21700 nM Bioactivity Info	TI LI LO TS
CP0381006 Compound Info	8-(naphthalene-2-carbonylamino)-4-oxochromene-2-carboxylic acid Show/Hide	C21H13NO5	1
1	IC50 = 29100 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000111 , MDA-MB-231

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Clinical Information about the Protein

Target 1 ( G-protein coupled receptor 55 (GPR55) )

Target Type	Successful Target
Disease	1 Target-related Disease				1
1	Attention deficit hyperactivity disorder [ICD-11: 6A05.Z]
Approved Drug(s)	1 Approved Drug				1
1	Guanfacine extended release	Drug Info	Approved	Attention deficit hyperactivity disorder

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han