General Information of the Protein
Protein ID
PT05068
Protein Name
Glycine receptor subunit alpha-1
Secondarily
Protein Name
Glycine receptor 48 kDa subunit
Glycine receptor strychnine-binding subunit
Gene Name
GLRA1
Sequence
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
Glycine receptor
Function
Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
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Uniprot ID
Primary ID:
P23415

Secondarily ID:
B2R6T3
Q14C77
Q6DJV9
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HGNC ID
HGNC:4326
Subcellular Location
Postsynaptic cell membrane
Synapse
Perikaryon
Cell projection
Dendrite
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0853022
 Compound Info 
8-hydroxyircinialactam B
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C27H39NO7
  1
1
EC50 = 500 nM
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CP0914087
 Compound Info 
(12E,20Z,18S)-8-hydroxy-variabilin
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C25H36O5
  1
1
EC50 = 1200 nM
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CP0008055
 Compound Info 
(4aR,5aS,8aR,13aS,15E,15aR,15bR)-15-prop-2-enoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
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C24H25N3O3
  2
1
IC50 = 49 nM
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2
Ki = 370 nM
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CP0003097
 Compound Info 
CHEBI:28973
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C21H22N2O2
  3
1
IC50 = 50 nM
 Bioactivity Info 
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2
IC50 = 51 nM
 Bioactivity Info 
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3
Ki = 23 nM
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CP0009017
 Compound Info 
(4aR,5aS,8aR,13aS,15E,15aR,15bR)-15-prop-2-ynoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
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C24H23N3O3
  1
1
IC50 = 59 nM
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CP0008081
 Compound Info 
(4aR,5aS,8aR,13aS,15E,15aR,15bR)-15-methoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
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C22H23N3O3
  2
1
IC50 = 75 nM
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2
Ki = 189 nM
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CP0003095
 Compound Info 
(4aR,5aS,8aR,13aS,15aS,15bR)-10-amino-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
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C21H23N3O2
  1
1
IC50 = 76 nM
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CP0010498
 Compound Info 
(4aR,5aS,8aR,13aS,15E,15aR,15bR)-15-hydroxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
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C21H21N3O3
  2
1
IC50 = 82 nM
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2
Ki = 40 nM
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CP0008292
 Compound Info 
N-[2-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-2-oxoethyl]octanamide
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C31H40N4O4
  1
1
IC50 = 90 nM
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CP0014664
 Compound Info 
N,N'-bis[2-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-2-oxoethyl]dodecanediamide
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C58H70N8O8
  1
1
IC50 = 100 nM
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CP0008849
 Compound Info 
(4aR,5aS,8aR,13aS,15E,15aR,15bR)-15-propoxyimino-2,4a,5,5a,7,8,13a,15a,15b,16-decahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
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C24H27N3O3
  2
1
IC50 = 109 nM
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2
Ki = 241 nM
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CP0014662
 Compound Info 
N,N'-bis[2-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-2-oxoethyl]heptanediamide
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C53H60N8O8
  1
1
IC50 = 130 nM
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CP0014663
 Compound Info 
N,N'-bis[2-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-2-oxoethyl]octanediamide
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C54H62N8O8
  1
1
IC50 = 170 nM
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CP0011374
 Compound Info 
N-[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]propanamide
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C24H27N3O3
  2
1
IC50 = 201 nM
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2
Ki = 67 nM
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CP0010011
 Compound Info 
N,N'-bis[2-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-2-oxoethyl]nonanediamide
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C55H64N8O8
  1
1
IC50 = 400 nM
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CP0871088
 Compound Info 
ginkgolide M
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C20H24O10
  1
1
IC50 = 650 nM
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CP0013664
 Compound Info 
N,N'-bis[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]dodecanediamide
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C54H64N6O6
  1
1
IC50 = 720 nM
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CP0008291
 Compound Info 
N,N'-bis[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]octanediamide
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C50H56N6O6
  1
1
IC50 = 1100 nM
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CP0010012
 Compound Info 
N,N'-bis[11-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-11-oxoundecyl]octanediamide
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C72H98N8O8
  1
1
IC50 = 1400 nM
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CP0011897
 Compound Info 
N,N'-bis[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]decanediamide
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C52H60N6O6
  1
1
IC50 = 1500 nM
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CP0180510
 Compound Info 
BN 52021
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C20H24O10
  1
1
IC50 = 1700 nM
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CP0373504
 Compound Info 
(1R,3R,6R,7S,8S,9S,11S,12S,13S,16S,17S)-8-tert-butyl-6,9,12,17-tetrahydroxy-13-methyl-2,4,15,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.012,16]nonadecane-5,14,18-trione
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C20H24O11
  2
1
IC50 = 1700 nM
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2
IC50 = 5900 nM
 Bioactivity Info 
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CP0007993
 Compound Info 
N-[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]-11-(octanoylamino)undecanamide
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C40H58N4O4
  1
1
IC50 = 1700 nM
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CP0014665
 Compound Info 
N,N'-bis[11-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-11-oxoundecyl]docosanediamide
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C86H126N8O8
  1
1
IC50 = 2900 nM
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CP0011899
 Compound Info 
N,N'-bis[11-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-11-oxoundecyl]dodecanediamide
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C76H106N8O8
  1
1
IC50 = 3100 nM
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CP0048517
 Compound Info 
(1R,3R,6R,7S,8S,10R,11S,13S,16S,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione
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C20H24O9
  1
1
IC50 = 3800 nM
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CP0003098
 Compound Info 
(4aR,5aS,8aS,13aS,15aS,15bR)-6-propyl-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-6-ium-14-one;bromide
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C24H29BrN2O2
  1
1
IC50 = 4590 nM
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CP0425003
 Compound Info 
(1S,3R,6R,7S,8S,9S,11S,12S,13S,16S)-8-tert-butyl-6,9,12-trihydroxy-13-methyl-2,4,15,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.012,16]nonadecane-5,14,18-trione
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C20H24O10
  1
1
IC50 = 6400 nM
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CP0373509
 Compound Info 
(1S,6R,8S,11S,13R,16R,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,18-dione
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C20H26O8
  1
1
IC50 > 100000 nM
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CP0405700
 Compound Info 
[(1R,6R,8S,11S,13S,16R,17S)-8-tert-butyl-16-methyl-5,15,18-trioxo-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecan-6-yl] acetate
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C22H26O9
  1
1
IC50 > 100000 nM
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CP0441951
 Compound Info 
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-5,15,18-trioxo-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-9-yl acetate
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C22H26O12
  1
1
IC50 > 100000 nM
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CP0441952
 Compound Info 
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-9-(ethylamino)-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
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C22H29NO10
  1
1
IC50 > 100000 nM
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CP0441953
 Compound Info 
(1R,2R,3S,6S,8S,10R,11R)-10-tert-butyl-2,11,16-trihydroxy-3-methyl-5,13,15-trioxapentacyclo[7.5.2.0^{1,8}.0^{2,6}.0^{8,12}]hexadecane-4,14-dione
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C18H24O8
  1
1
IC50 > 100000 nM
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CP0441958
 Compound Info 
(1S,6R,8S,11R,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,9,15,18-tetrone
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C20H22O11
  1
1
IC50 > 100000 nM
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CP0445825
 Compound Info 
1,2;3,14-dianhydro-ginkgolide C
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C20H20O9
  1
1
IC50 > 100000 nM
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CP0445836
 Compound Info 
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-5,15,18-trioxo-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-9-yl 2-phenylacetate
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C28H30O12
  1
1
IC50 > 100000 nM
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CP0486277
 Compound Info 
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,9,12,17-tetrahydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
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C20H24O11
  1
1
IC50 > 100000 nM
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CP0498087
 Compound Info 
(1S,6R,8S,11S,13S,16R,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-18-one
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C20H28O7
  1
1
IC50 > 100000 nM
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CP0502368
 Compound Info 
methyl (2E)-2-[(1R,6R,8S,11S)-8-tert-butyl-6-hydroxy-5,15-dioxo-2,4,16-trioxapentacyclo[8.4.2.01,11.03,7.07,11]hexadecan-14-ylidene]propanoate
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C21H26O8
  1
1
IC50 > 100000 nM
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CP0373510
 Compound Info 
methyl 2-[(1R,6R,8S,11S,14R)-8-tert-butyl-6-hydroxy-5,15-dioxo-2,4,16-trioxapentacyclo[8.4.2.01,11.03,7.07,11]hexadecan-14-yl]propanoate
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C21H28O8
  1
1
IC50 > 100000 nM
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CP0435621
 Compound Info 
(1S,6R,8S,9R,11S,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-5,15,18-trioxo-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-9-yl trifluoromethanesulfonate
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C21H23F3O13S
  1
1
IC50 > 100000 nM
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CP0435622
 Compound Info 
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-9-(methylamino)-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
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C21H27NO10
  1
1
IC50 > 100000 nM
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CP0435625
 Compound Info 
(1S,8S,11S,13S,16S,17R)-8-tert-butyl-17-hydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,6,15,18-tetrone
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C20H22O9
  1
1
IC50 > 100000 nM
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CP0441954
 Compound Info 
(1R,6R,8S,11S)-8-tert-butyl-6,13-dimethoxy-2,4,14,17-tetraoxapentacyclo[8.5.2.0^{1,11}.0^{3,7}.0^{7,11}]heptadecane-5,15,16-trione
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C19H24O9
  1
1
IC50 > 100000 nM
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CP0441956
 Compound Info 
10-methoxymethyloxy-ginkgolide A
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C22H28O10
  1
1
IC50 > 100000 nM
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CP0445829
 Compound Info 
(1R,6R,8S,11S,13S,16R,17R)-8-tert-butyl-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-6,17-diol
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C20H30O6
  1
1
IC50 > 100000 nM
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CP0445831
 Compound Info 
(1R,6R,8S,11R)-8-tert-butyl-13-methoxy-5,15,16-trioxo-2,4,14,17-tetraoxapentacyclo[8.5.2.0^{1,11}.0^{3,7}.0^{7,11}]heptadecan-6-yl acetate
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C20H24O10
  1
1
IC50 > 100000 nM
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CP0445833
 Compound Info 
(1S,2R,3S,6S,8S,10R)-10-tert-butyl-2-hydroxy-3-methyl-5,13,15-trioxapentacyclo[7.5.2.0^{1,8}.0^{2,6}.0^{8,12}]hexadecane-4,14,16-trione
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C18H22O7
  1
1
IC50 > 100000 nM
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CP0486272
 Compound Info 
(6R,8S,11S,16R,17S)-8-tert-butyl-6,16,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
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C20H24O10
  1
1
IC50 > 100000 nM
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CP0498088
 Compound Info 
methyl (2R)-2-[(1S,2R,3S,6S,8S,10S)-10-tert-butyl-2-hydroxy-16-methoxy-3-methyl-4,14-dioxo-5,13,15-trioxapentacyclo[7.5.2.01,8.02,6.08,12]hexadecan-9-yl]-2-methoxyacetate
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C23H32O10
  1
1
IC50 > 100000 nM
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CP0505243
 Compound Info 
10-acetoxy-ginkgolide B
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C22H26O10
  1
1
IC50 > 100000 nM
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CP0000589
 Compound Info 
Alcuronium
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C44H50N4O2+2
  1
1
IC50 > 100000 nM
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CP0001237
 Compound Info 
(1R,9R,18S,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene
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C38H42N4O2
  1
1
IC50 > 100000 nM
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CP0633393
 Compound Info 
[(20-{[dimethyl(prop-2-en-1-yl)azaniumyl]methyl}-3,13-diazapentacyclo[11.7.0.0^{3,11}.0^{4,9}.0^{14,19}]icosa-1(20),4,6,8,10,14(19),15,17-octaen-10-yl)methyl]dimethylprop-2-en-1-ylazanium dibromide
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C30H38Br2N4
  1
1
IC50 > 100000 nM
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CP0633394
 Compound Info 
(1S,11S,13S,17R,18R,20R,27S,29R,30R,31S,35E)-35-(2-hydroxyethylidene)-14,26-dimethyl-19-phenyl-21-oxa-8,14,19,26-tetraazadecacyclo[24.5.2.2^{11,14}.0^{1,27}.0^{2,7}.0^{8,31}.0^{10,18}.0^{13,17}.0^{20,30}.0^{24,29}]pentatriaconta-2,4,6,9,23-pentaene-14,26-diium diiodide
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C40H48I2N4O2
  1
1
IC50 > 100000 nM
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CP0633395
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-dibenzyl-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-diium dibromide
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C52H56Br2N4O2
  1
1
IC50 > 100000 nM
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CP0633396
 Compound Info 
(1R,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24-phenyl-15-(prop-2-en-1-yl)-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaen-15-ium bromide
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C41H47BrN4O2
  1
1
IC50 > 100000 nM
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CP0633629
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-bis[(3,4-dimethoxyphenyl)methyl]-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-diium dichloride
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C56H64Cl2N4O6
  1
1
IC50 > 100000 nM
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CP0633630
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-bis(cyclohex-2-en-1-yl)-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-bis(ylium) dibromide
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C50H60Br2N4O2
  1
1
IC50 > 100000 nM
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CP0633631
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24-phenyl-15,31-bis(prop-2-en-1-yl)-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-diium dibromide
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C44H52Br2N4O2
  1
1
IC50 > 100000 nM
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CP0633632
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-bis[(4-bromophenyl)methyl]-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-diium dibromide
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C52H54Br4N4O2
  1
1
IC50 > 100000 nM
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CP0633633
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-bis[(4-nitrophenyl)methyl]-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-diium dibromide
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C52H54Br2N6O6
  1
1
IC50 > 100000 nM
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CP0633634
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-bis[2-(acetyloxy)ethyl]-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-diium dibromide
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C46H56Br2N4O6
  1
1
IC50 > 100000 nM
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CP0633635
 Compound Info 
toxiferine
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C40H46Cl2N4O2
  1
1
IC50 > 100000 nM
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CP0633846
 Compound Info 
{[20-({dimethyl[(4-nitrophenyl)methyl]azaniumyl}methyl)-3,13-diazapentacyclo[11.7.0.0^{3,11}.0^{4,9}.0^{14,19}]icosa-1(20),4,6,8,10,14(19),15,17-octaen-10-yl]methyl}dimethyl[(4-nitrophenyl)methyl]azanium dibromide
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C38H40Br2N6O4
  1
1
IC50 > 100000 nM
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CP0633847
 Compound Info 
(1S,11S,13S,17R,18R,20R,27S,29R,30R,31S,35E)-14,26-bis[(3,4-dimethoxyphenyl)methyl]-35-(2-hydroxyethylidene)-19-phenyl-21-oxa-8,14,19,26-tetraazadecacyclo[24.5.2.2^{11,14}.0^{1,27}.0^{2,7}.0^{8,31}.0^{10,18}.0^{13,17}.0^{20,30}.0^{24,29}]pentatriaconta-2,4,6,9,23-pentaene-14,26-diium dichloride
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C56H64Cl2N4O6
  1
1
IC50 > 100000 nM
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CP0633848
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-bis[(2E)-but-2-en-1-yl]-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-diium dibromide
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C46H56Br2N4O2
  1
1
IC50 > 100000 nM
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CP0633849
 Compound Info 
(1S,11S,13S,17R,18R,20R,27S,29R,30R,31S,35E)-14,26-bis(cyclohex-2-en-1-yl)-35-(2-hydroxyethylidene)-19-phenyl-21-oxa-8,14,19,26-tetraazadecacyclo[24.5.2.2^{11,14}.0^{1,27}.0^{2,7}.0^{8,31}.0^{10,18}.0^{13,17}.0^{20,30}.0^{24,29}]pentatriaconta-2,4,6,9,23-pentaene-14,26-bis(ylium) dibromide
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C50H60Br2N4O2
  1
1
IC50 > 100000 nM
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CP0633850
 Compound Info 
trimethyl({20-[(trimethylazaniumyl)methyl]-3,13-diazapentacyclo[11.7.0.0^{3,11}.0^{4,9}.0^{14,19}]icosa-1(20),4,6,8,10,14(19),15,17-octaen-10-yl}methyl)azanium diiodide
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C26H34I2N4
  1
1
IC50 > 100000 nM
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CP0633851
 Compound Info 
(1S,11S,13S,18R,20R,27S,29R,30R,31S,35E)-35-(2-hydroxyethylidene)-14,26-bis[(4-nitrophenyl)methyl]-19-phenyl-21-oxa-8,14,19,26-tetraazadecacyclo[24.5.2.2^{11,14}.0^{1,27}.0^{2,7}.0^{8,31}.0^{10,18}.0^{13,17}.0^{20,30}.0^{24,29}]pentatriaconta-2,4,6,9,23-pentaene-14,26-diium dibromide
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C52H54Br2N6O6
  1
1
IC50 > 100000 nM
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CP0633852
 Compound Info 
2-[(1R,11S,13S,17S,18R,20R,27S,29R,30R,31S,35E)-19-phenyl-21-oxa-8,14,19,26-tetraazadecacyclo[24.5.2.2^{11,14}.0^{1,27}.0^{2,7}.0^{8,31}.0^{10,18}.0^{13,17}.0^{20,30}.0^{24,29}]pentatriaconta-2,4,6,9,23-pentaen-35-ylidene]ethan-1-ol
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C38H42N4O2
  1
1
IC50 > 100000 nM
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CP0634165
 Compound Info 
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-dimethyl-24-phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene-15,31-diium diiodide
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C40H48I2N4O2
  1
1
IC50 > 100000 nM
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Cell Line ID: CL000027 , tsA201
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0003097
 Compound Info 
CHEBI:28973
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C21H22N2O2
  2
1 IC50 = 27 nM
2 IC50 = 134 nM
CP0012887
 Compound Info 
N-[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]-11-[3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-[[11-[[(4aR,5aS,8aR,13aS,15aS,15bR)-14-oxo-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-10-yl]amino]-11-oxoundecyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]undecanamide
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C92H138N8O20
  2
1 IC50 = 67 nM
2 IC50 = 3312 nM
Clinical Information about the Protein
Target 1 ( Strychnine-binding glycine receptor (GLRA1) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Muscle spasm [ICD-11: MB47.3]
2 Sepsis [ICD-11: 1G40-1G41]
Approved Drug(s) 1 Approved Drug  1
1 THIOCOLCHICOSIDE
 Drug Info 
Approved
Muscle spasm
Discontinued Drug(s) 1 Discontinued Drug  1
1 GINKOLIDE B
 Drug Info 
Terminated
Sepsis