General Information of the Compound
Compound ID
CP0003097
Compound Name
CHEBI:28973
    Show/Hide
Synonyms
(-)-Strychnine
(-)-Strychnine, 98%
57-24-9
Boomer-rid
CHEBI:28973
Caswell No 805
Dolco mouse cereal
EINECS 200-319-7
EPA Pesticide Chemical Code 076901
Estricnina
Gopher bait
Gopher-gitter
H9Y79VD43J
HSDB 2001
Hare-Rid
Kwik-kil
Mole death
Mouse-nots
Mouse-rid
Mouse-tox
NSC 5365
Pied piper mouse seed
RCRA waste number P108
STRYCHNINE
Sanaseed
Stricnina [Italian]
Strychinos
Strychnidin-10-one
Strychnin
Strychnin [German]
Strychnine
Strychnine [BSI:ISO]
Strychnos
UN1692
UNII-H9Y79VD43J
[3H]strychnine
strychnine
    Show/Hide
Structure
Formula
C21H22N2O2
Molecular Weight
334.419
Canonical SMILES
O=C1C[C@@H]2OCC=C3CN4CC[C@@]56[C@@H]4C[C@@H]3[C@@H]2[C@@H]5N1c1ccccc61
    Show/Hide
InChI
InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1
    Show/Hide
InChIKey
QMGVPVSNSZLJIA-FVWCLLPLSA-N
CAS
57-24-9
Physicochemical Property
logP
2.0925
Rotatable Bonds
0
Heavy Atom Count
25
Polar Areas
32.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 441071
SID: 15988875
ChEMBL ID
CHEMBL227934
DrugBank ID
DB15954
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05068, Glycine receptor subunit alpha-1
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 50 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 51 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
Ki = 23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 27 nM
2 IC50 = 134 nM
Protein ID: PT06764, Taste receptor type 2 member 10
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000902 HEK293/Galpha15
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( [3H]strychnine )
Drug Name [3H]strychnine
Target(s)
Strychnine-binding glycine receptor (GLRA1)
 Target Info 
Inhibitor