General Information of the Protein
Protein ID
PT05029
Protein Name
Neuromedin-K receptor
Secondarily
Protein Name
NK-3 receptor
Neurokinin B receptor
Tachykinin receptor 3
Gene Name
TACR3
Sequence
MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS
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Organism
Cavia porcellus, Guinea pig
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neurokinin receptor
Function
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
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Uniprot ID
Primary ID:
P30098

Secondarily ID:
Q925R4
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Ensembl ID
ENSG00000169836
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0074738
(S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl)-4-phenylpiperidin-4-yl)-N-methylacetamine
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C35H41Cl2N3O2
 5
1
Kd = 0.08 nM
   TI
   LI
   LO
   TS
2
Kd = 0.15 nM
   TI
   LI
   LO
   TS
3
Kd = 3.162 nM
   TI
   LI
   LO
   TS
4
Ki = 0.6 nM
   TI
   LI
   LO
   TS
5
Ki = 0.8 nM
   TI
   LI
   LO
   TS
CP0376631
2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluoromethylbenzyl)-2,N-dimethyl-4-[4-(2-oxo-pyrrolidin-1-yl)-piperidin-1-yl]-butyramide
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C29H33Cl2F4N3O2
 3
1
Kd = 10.96 nM
   TI
   LI
   LO
   TS
2
Ki = 1.6 nM
   TI
   LI
   LO
   TS
3
Ki = 1.8 nM
   TI
   LI
   LO
   TS
CP0114970
(S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide
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C25H22N2O2
 4
1
Kd = 12.3 nM
   TI
   LI
   LO
   TS
2
Kd = 15.49 nM
   TI
   LI
   LO
   TS
3
Ki = 3.8 nM
   TI
   LI
   LO
   TS
4
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0374063
4-[4-(acetylmethyl-amino)-piperidin-1-yl]-2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluoromethylbenzyl)-2,N-dimethylbutyramide
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C28H33Cl2F4N3O2
 3
1
Kd = 14.79 nM
   TI
   LI
   LO
   TS
2
Ki = 2.7 nM
   TI
   LI
   LO
   TS
3
Ki = 3.5 nM
   TI
   LI
   LO
   TS
CP0397341
4-[4-(acetylmethyl-amino)-piperidin-1-yl]-N-(2-chloro-benzyl)-2-(3,4-dichlorophenyl)-2,N-dimethylbutyramide
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C27H34Cl3N3O2
 4
1
Kd = 23.99 nM
   TI
   LI
   LO
   TS
2
Kd = 29.51 nM
   TI
   LI
   LO
   TS
3
Ki = 8 nM
   TI
   LI
   LO
   TS
4
Ki = 11.9 nM
   TI
   LI
   LO
   TS