Protein Information

General Information of the Protein

Protein ID	PT04857
Protein Name	Proto-oncogene Wnt-3
Secondarily Protein Name	Proto-oncogene Int-4 homolog
Gene Name	WNT3
Secondarily Gene Name	INT4
Sequence	MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Secreted protein
Function	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). Show/Hide
Uniprot ID	Primary ID: P56703 Secondarily ID: Q2M237 Q9H1J9 Show/Hide
HGNC ID	HGNC:12782
Subcellular Location	Secreted Extracellular space Extracellular matrix Secreted

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000309 , NCTC clone 929

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0913220 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-N-methyl-N-quinolin-8-yl-benzamide Show/Hide	C25H21N3O3	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0505121 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-cyclohexanecarboxylic acid quinolin-8-ylamide Show/Hide	C25H25N3O3	1
1	EC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0919907 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(7-methyl-quinolin-8-yl)-benzamide Show/Hide	C26H21N3O3	1
1	EC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0469660 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-cyclohexanecarboxylic acid(7-methyl-quinolin-8-yl)-amide Show/Hide	C26H27N3O3	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0497531 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-cyclohexanecarboxylic acid(4-methyl-quinolin-8-yl)-amide Show/Hide	C26H27N3O3	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0860629 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(2-methoxy-phenyl)-benzamide Show/Hide	C23H20N2O4	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0870422 Compound Info	2-Chloro-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-quinolin-8-yl-benzamide Show/Hide	C25H18ClN3O3	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0916216 Compound Info	N-(4-Bromo-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H17BrN2O3	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0870423 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-2-methyl-N-quinolin-8-yl-benzamide Show/Hide	C26H21N3O3	1
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0919908 Compound Info	trans-4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(2-methoxy-cyclohexyl)-benzamide Show/Hide	C23H26N2O4	1
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0870419 Compound Info	N-(4-Chloro-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H17ClN2O3	1
1	EC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0908469 Compound Info	N-(3,4-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16F2N2O3	1
1	EC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0908467 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(4-fluoro-phenyl)-benzamide Show/Hide	C22H17FN2O3	1
1	EC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0669064 Compound Info	4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-quinolin-8-yl-benzamide Show/Hide	C25H19N3O3	1
1	EC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0915775 Compound Info	N-(3,4-Dichloro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16Cl2N2O3	1
1	EC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0870420 Compound Info	N-(2,4-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16F2N2O3	1
1	EC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0902092 Compound Info	N-(3-Bromo-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H17BrN2O3	1
1	EC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0439533 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-piperidine-1-carboxylic acid quinolin-8-ylamide Show/Hide	C24H24N4O3	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0501391 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid(7-methyl-quinolin-8-yl)-amide Show/Hide	C27H29N3O3	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0858259 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(5,6,7,8-tetrahydro-quinolin-8-yl)-benzamide Show/Hide	C25H23N3O3	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0858261 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-pyridin-4-ylmethyl-benzamide Show/Hide	C22H19N3O3	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0879924 Compound Info	N-(3,4-Dibromo-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16Br2N2O3	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0916541 Compound Info	N-(2,4-Dichloro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16Cl2N2O3	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0857598 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-(3-trifluoromethyl-phenyl)-benzamide Show/Hide	C23H17F3N2O3	1
1	EC50 = 20000 nM Bioactivity Info	TI LI LO TS
CP0891007 Compound Info	N-Benzyl-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C23H20N2O3	1
1	EC50 = 20000 nM Bioactivity Info	TI LI LO TS
CP0481673 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid(4-methyl-quinolin-8-yl)-amide Show/Hide	C27H29N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0505122 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid quinolin-8-ylamide Show/Hide	C26H27N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0858260 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(2-trifluoromethyl-phenyl)-benzamide Show/Hide	C23H17F3N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0860630 Compound Info	N-(2-Chloro-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H17ClN2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0860631 Compound Info	N-(2,5-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16F2N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0860632 Compound Info	1-[4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-phenyl]-3-quinolin-8-yl-urea Show/Hide	C25H20N4O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0870421 Compound Info	N-Cyclohexyl-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H24N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0879921 Compound Info	4-((1R,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-phenyl-benzamide Show/Hide	C22H18N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0879923 Compound Info	N-(2,6-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16F2N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0879925 Compound Info	3-Chloro-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-quinolin-8-yl-benzamide Show/Hide	C25H18ClN3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0879926 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-2-methoxy-N-quinolin-8-yl-benzamide Show/Hide	C26H21N3O4	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0891005 Compound Info	N-(3-Chloro-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H17ClN2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0891006 Compound Info	N-(3,5-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16F2N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0902062 Compound Info	N-(2-Bromo-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H17BrN2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0902063 Compound Info	trans-4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-((2-hydroxy-cyclohexyl)-benzamide Show/Hide	C22H24N2O4	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0908465 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(2-fluoro-phenyl)-benzamide Show/Hide	C22H17FN2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0908470 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-methyl-N-quinolin-8-yl-benzamide Show/Hide	C26H21N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0908499 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(3-fluoro-phenyl)-benzamide Show/Hide	C22H17FN2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0916217 Compound Info	N-(2,4-Dibromo-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16Br2N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0916218 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-pyridin-2-ylmethyl-benzamide Show/Hide	C22H19N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0916540 Compound Info	N-(2,3-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-benzamide Show/Hide	C22H16F2N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0916542 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(4-trifluoromethyl-phenyl)-benzamide Show/Hide	C23H17F3N2O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0916543 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-pyridin-3-ylmethyl-benzamide Show/Hide	C22H19N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0919909 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-3-methoxy-N-quinolin-8-yl-benzamide Show/Hide	C26H21N3O4	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0935534 Compound Info	4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-3-methyl-N-quinolin-8-yl-benzamide Show/Hide	C26H21N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000043 , U2OS

Cell Line Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han