General Information of the Protein
| Protein ID |
PT04536
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| Protein Name |
Lysophosphatidic acid receptor 2
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| Secondarily Protein Name |
Lysophosphatidic acid receptor Edg-4
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| Gene Name |
LPAR2
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| Secondarily Gene Name |
EDG4
LPA2
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| Sequence |
MGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Lipid-like ligand receptor (family A GPCR)
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EDG receptor
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| Function |
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Cell surface
Cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000555 , B103
Cell Line ID: CL000011 , CHO
Cell Line ID: CL000025 , HEK-293T
Cell Line ID: CL000466 , McA-RH7777
Cell Line ID: CL001056 , MEF-1 [Mouse fibroblast]
Clinical Information about the Protein
Target 1 ( Lysophosphatidic acid receptor 2 (LPAR2) )
| Target Type | Literature-reported Target | ||||
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