General Information of the Protein
Protein ID
PT03816
Protein Name
C-C chemokine receptor type 8
Secondarily
Protein Name
CC chemokine receptor CHEMR1
CMKBRL2
Chemokine receptor-like 1
GPR-CY6
TER1
Gene Name
CCR8
Secondarily
Gene Name
CKRL1
CMKBR8
CMKBRL2
Sequence
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
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Uniprot ID
Primary ID:
P51685

Secondarily ID:
B2RC64
Q3KNQ8
Q3KNR3
Q9BYX5
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Ensembl ID
ENSG00000179934
HGNC ID
HGNC:1609
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000076 , CHO/Galpha16
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0439479
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-2-methylbenzamide
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C27H31N3O4S
  1
1
IC50 = 0.3 nM
 Bioactivity Info 
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CP0378516
 Compound Info 
3-pyrrolidin-1-ylpropyl 4-[({4-[(2-methylbenzoyl)amino]-1-naphthyl}sulfonyl)amino]piperidine-1-carboxylate
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C31H38N4O5S
  1
1
IC50 = 4.2 nM
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CP0420535
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-3-methylbenzamide
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C27H31N3O4S
  1
1
IC50 = 5.1 nM
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CP0529662
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]cyclohexanecarboxamide
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C26H35N3O4S
  1
1
IC50 = 6.1 nM
 Bioactivity Info 
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CP0536555
 Compound Info 
4-tert-butyl-N-(4-{[(1-butyrylpiperidin-4-yl)amino]sulfonyl}-1-naphthyl)benzamide
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C30H37N3O4S
  1
1
IC50 = 6.9 nM
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CP0435926
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-2-phenylbutanamide
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C29H35N3O4S
  1
1
IC50 = 7.65 nM
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CP0542291
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-4-methylbenzamide
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C27H31N3O4S
  1
1
IC50 = 9.5 nM
 Bioactivity Info 
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CP0435932
 Compound Info 
3-(dimethylamino)propyl 4-[({4-[(2-methylbenzoyl)amino]-1-naphthyl}sulfonyl)amino]piperidine-1-carboxylate
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C29H36N4O5S
  1
1
IC50 = 9.8 nM
 Bioactivity Info 
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CP0543734
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-4-ethylbenzamide
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C28H33N3O4S
  1
1
IC50 = 10.8 nM
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CP0529666
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]benzamide
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C26H29N3O4S
  1
1
IC50 = 12.5 nM
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CP0529667
 Compound Info 
3-(diethylamino)propyl 4-[({4-[(2-methylbenzoyl)amino]-1-naphthyl}sulfonyl)amino]piperidine-1-carboxylate
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C31H40N4O5S
  1
1
IC50 = 14.5 nM
 Bioactivity Info 
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CP0435931
 Compound Info 
4-butyl-N-(4-{[(1-butyrylpiperidin-4-yl)amino]sulfonyl}-1-naphthyl)benzamide
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C30H37N3O4S
  1
1
IC50 = 15.3 nM
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CP0439477
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-2-fluorobenzamide
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C26H28FN3O4S
  1
1
IC50 = 19.2 nM
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CP0543736
 Compound Info 
3-(2,6-dimethylmorpholin-4-yl)propyl-4-[({4-[(2-methylbenzoyl)amino]-1-naphthyl}sulfonyl)amino]piperidine-1-carboxylate
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C33H42N4O6S
  1
1
IC50 = 19.6 nM
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CP0529665
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-3-fluorobenzamide
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C26H28FN3O4S
  1
1
IC50 = 20 nM
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CP0435929
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-1-methylimidazole-2-carboxamide
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C24H29N5O4S
  1
1
IC50 = 20.4 nM
 Bioactivity Info 
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CP0483809
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-1-benzothiophene-2-carboxamide
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C28H29N3O4S2
  1
1
IC50 = 23.6 nM
 Bioactivity Info 
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CP0562406
 Compound Info 
4-(benzyloxy)-N-(4-{[(1-butyrylpiperidin-4-yl)amino]sulfonyl}-1-naphthyl)benzamide
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C33H35N3O5S
  1
1
IC50 = 24.6 nM
 Bioactivity Info 
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CP0543735
 Compound Info 
3-(3,4-dihydroisoquinolin-2(1H)-yl)propyl 4-[({4-[(2-methylbenzoyl)amino]-1-naphthyl}sulfonyl)amino]piperidine-1-carboxylate
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C36H40N4O5S
  1
1
IC50 = 28.6 nM
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CP0542290
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-4-pentylbenzamide
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C31H39N3O4S
  1
1
IC50 = 36.1 nM
 Bioactivity Info 
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CP0435930
 Compound Info 
3-tert-butyl-N-(4-{[(1-butyrylpiperidin-4-yl)amino]sulfonyl}-1-naphthyl)-1-methyl-1H-pyrazole-5-carboxamide
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C28H37N5O4S
  1
1
IC50 = 37 nM
 Bioactivity Info 
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CP0541874
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]pyridine-2-carboxamide
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C25H28N4O4S
  1
1
IC50 = 41.7 nM
 Bioactivity Info 
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CP0378514
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-2-chloro-6-methylpyridine-4-carboxamide
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C26H29ClN4O4S
  1
1
IC50 = 43.9 nM
 Bioactivity Info 
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CP0562414
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-5-methyl-2-(trifluoromethyl)furan-3-carboxamide
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C26H28F3N3O5S
  1
1
IC50 = 46.9 nM
 Bioactivity Info 
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CP0524630
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]cyclobutanecarboxamide
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C24H31N3O4S
  1
1
IC50 = 57.9 nM
 Bioactivity Info 
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CP0528144
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-4-fluorobenzamide
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C26H28FN3O4S
  1
1
IC50 = 59.5 nM
 Bioactivity Info 
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CP0541873
 Compound Info 
ethyl 4-[[4-(pyridine-4-carbonylamino)naphthalen-1-yl]sulfonylamino]piperidine-1-carboxylate
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C24H26N4O5S
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0543733
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-2-cyclopentylacetamide
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C26H35N3O4S
  1
1
IC50 = 144.5 nM
 Bioactivity Info 
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CP0505231
 Compound Info 
N-[4-[(4-methoxyphenyl)sulfamoyl]naphthalen-1-yl]benzamide
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C24H20N2O4S
  1
1
IC50 = 150 nM
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CP0529660
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]oxane-4-carboxamide
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C25H33N3O5S
  1
1
IC50 = 205.9 nM
 Bioactivity Info 
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CP0562413
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-2-methylpyridine-3-carboxamide
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C26H30N4O4S
  1
1
IC50 = 280 nM
 Bioactivity Info 
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CP0435928
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]cyclopentanecarboxamide
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C25H33N3O4S
  1
1
IC50 = 365 nM
 Bioactivity Info 
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CP0490479
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]cyclopropanecarboxamide
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C23H29N3O4S
  1
1
IC50 = 367.7 nM
 Bioactivity Info 
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CP0542294
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-3,3-dimethylbutanamide
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C25H35N3O4S
  1
1
IC50 = 612.5 nM
 Bioactivity Info 
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CP0435927
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]-2-ethylbutanamide
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C25H35N3O4S
  1
1
IC50 = 638.5 nM
 Bioactivity Info 
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CP0524631
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]pyridine-3-carboxamide
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C25H28N4O4S
  1
1
IC50 = 885.1 nM
 Bioactivity Info 
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CP0562412
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]pyrazine-2-carboxamide
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C24H27N5O4S
  1
1
IC50 = 1004 nM
 Bioactivity Info 
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CP0536553
 Compound Info 
N-[4-[(1-butanoylpiperidin-4-yl)sulfamoyl]naphthalen-1-yl]furan-3-carboxamide
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C24H27N3O5S
  1
1
IC50 = 1519 nM
 Bioactivity Info 
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CP0529661
 Compound Info 
1-methyl-piperidine-4-carboxylic acid [4-(1-butyryl-piperidin-4-ylsulfamoyl)-naphthalen-1-yl]-amide
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C26H36N4O4S
  1
1
IC50 > 1900 nM
 Bioactivity Info 
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CP0453754
 Compound Info 
N-[4-[[(1-butanoylpiperidin-4-yl)amino]methyl]naphthalen-1-yl]-2-methylbenzamide
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C28H33N3O2
  1
1
IC50 > 3300 nM
 Bioactivity Info 
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CP0524629
 Compound Info 
N-(1-butanoylpiperidin-4-yl)-4-[(2-methylbenzoyl)amino]naphthalene-1-carboxamide
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C28H31N3O3
  1
1
IC50 > 3300 nM
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Cell Line ID: CL000059 , HuT 78
 Cell Line Info 
Cell Line ID: CL000233 , L1.2
 Cell Line Info 
Cell Line ID: CL000194 , RBL-1
 Cell Line Info 
Cell Line ID: CL000783 , UE6E7T-2
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( C-C chemokine receptor type 8 (CCR8) )
Target Type Clinical trial Target