General Information of the Protein
| Protein ID |
PT03648
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| Protein Name |
Isocitrate dehydrogenase [NADP], mitochondrial
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| Secondarily Protein Name |
ICD-M
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
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| Gene Name |
IDH2
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| Sequence |
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Oxidoreductase
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| Function |
Plays a role in intermediary metabolism and energy production (PubMed:22416140, PubMed:19228619). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:22416140, PubMed:19228619).
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| Uniprot ID |
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| Ensembl ID | |||||
| HGNC ID | |||||
| Subcellular Location |
Mitochondrion
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000067 , HCT 116
| Compound ID | Compound Name | Compound Formula | |
| CP0107120 |
US10112931, Example 466
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C23H22F4N6O2
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2 |
| 1 |
IC50 = 3800 nM
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TI
LI
LO
TS
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| 2 |
IC50 = 10000 nM
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TI
LI
LO
TS
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Cell Line ID: CL000013 , Sf9
Cell Line ID: CL000102 , U-87MG ATCC
Biochemical Assays