General Information of the Protein
Protein ID
PT03632
Protein Name
Sigma intracellular receptor 2
Secondarily
Protein Name
Meningioma-associated protein 30
Transmembrane protein 97
Gene Name
TMEM97
Secondarily
Gene Name
MAC30
S2R
Sequence
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Intracellular sigma-2 receptor that binds histatin 1/HN1 (Hst 1) at the endoplasmic reticulun (ER) membrane, which is critical for mitochondrial-targeting and -activating properties of Hst1 (PubMed:34233061, PubMed:35970844). Thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588).
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Uniprot ID
Primary ID:
Q5BJF2

Secondarily ID:
B4DS02
Q07823
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Ensembl ID
ENSG00000109084
HGNC ID
HGNC:28106
Subcellular Location
Nucleus membrane
Rough endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0426385
 Compound Info 
(3aS,9bS)-3a-methyl-8-phenyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole
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C18H19NO
  1
1
Ki = 79.43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432125
 Compound Info 
(3aS,9bS)-8-bromo-5-(4-bromophenyl)-3a-methyl-2,3,4,9b-tetrahydro-1H-pyrrolo[2,3-c]quinoline
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C18H18Br2N2
  1
1
Ki = 79.43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391127
 Compound Info 
(3aS,9bS)-3a-methyl-7-phenylmethoxy-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole
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C19H21NO2
  1
1
Ki = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426383
 Compound Info 
(3aS,9bS)-3a-methyl-6-phenyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole
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C18H19NO
  1
1
Ki = 125.89 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391130
 Compound Info 
(3aS,9bS)-3,3a-dimethyl-5-phenyl-1,2,4,9b-tetrahydropyrrolo[2,3-c]quinoline
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C19H22N2
  1
1
Ki = 158.49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426378
 Compound Info 
(3aS,9bS)-3,3a-dimethyl-6-phenyl-1,2,4,9b-tetrahydrochromeno[3,4-b]pyrrole
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C19H21NO
  1
1
Ki = 316.23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426382
 Compound Info 
(3aS,9bS)-3a,7,9-trimethyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole
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C14H19NO
  1
1
Ki = 316.23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426405
 Compound Info 
(3aS,9bS)-3a,8-dimethyl-5-(4-methylphenyl)-2,3,4,9b-tetrahydro-1H-pyrrolo[2,3-c]quinoline
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C20H24N2
  1
1
Ki = 316.23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0437998
 Compound Info 
(3S,4S)-4-ethyl-3-methyl-6-phenyl-2,4-dihydrochromen-3-amine
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C18H21NO
  1
1
Ki = 316.23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455600
 Compound Info 
(3S,4S)-4-ethyl-3-methyl-2,4-dihydrobenzo[h]chromen-3-amine
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C16H19NO
  1
1
Ki = 316.23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0411059
 Compound Info 
(3S,4S)-4-ethyl-3-methyl-1-phenyl-2,4-dihydroquinolin-3-amine
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C18H22N2
  1
1
Ki = 630.96 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426384
 Compound Info 
(3aS,9bS)-6-bromo-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole
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C12H14BrNO
  1
1
Ki = 630.96 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387083
 Compound Info 
(3aS,9bS)-3a-methyl-5-phenyl-2,3,4,9b-tetrahydro-1H-pyrrolo[2,3-c]quinoline
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C18H20N2
  1
1
Ki = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455607
 Compound Info 
(3aS,9bS)-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrol-7-ol
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C12H15NO2
  1
1
Ki = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0117807
 Compound Info 
4-[4-[1-[4-[1-(6-aminohexyl)triazol-4-yl]butyl]piperidin-4-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C41H46F3N5O2
  1
1
Ki = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391128
 Compound Info 
1-[(3aS,9bS)-3a-methyl-6-phenyl-1,2,4,9b-tetrahydrochromeno[3,4-b]pyrrol-3-yl]ethanone
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C20H21NO2
  1
1
Ki = 1258.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432102
 Compound Info 
1-[(3aS,9bS)-3a-methyl-5-phenyl-1,2,4,9b-tetrahydropyrrolo[2,3-c]quinolin-3-yl]ethanone
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C20H22N2O
  1
1
Ki = 1258.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426421
 Compound Info 
(1S,2S)-1-ethyl-2-methyl-1,3-dihydrobenzo[f]chromen-2-amine
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C16H19NO
  1
1
Ki = 1995.26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426380
 Compound Info 
(3aS,9bS)-8-methoxy-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole
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C13H17NO2
  1
1
Ki = 3162.28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426381
 Compound Info 
(3aS,9bS)-3,3a-dimethyl-1,2,4,9b-tetrahydrochromeno[3,4-b]pyrrol-7-ol
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C13H17NO2
  1
1
Ki = 3981.07 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391120
 Compound Info 
(1S,2R)-1-ethyl-7-methoxy-2-methyl-3,4-dihydro-1H-naphthalen-2-amine
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C14H21NO
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391121
 Compound Info 
(3S,4S)-4-ethyl-3,6-dimethyl-2,4-dihydrochromen-3-amine
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C13H19NO
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391154
 Compound Info 
(3aS,9bS)-7,9-dimethoxy-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole
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C14H19NO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416007
 Compound Info 
(3S,4S)-3-amino-4-ethyl-3-methyl-2,4-dihydrochromen-7-ol
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C12H17NO2
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0421273
 Compound Info 
(3S,4S)-4-ethyl-6-methoxy-3-methyl-2,4-dihydrochromen-3-amine
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C13H19NO2
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432122
 Compound Info 
1-[(3aS,9bS)-7-hydroxy-3a-methyl-1,2,4,9b-tetrahydrochromeno[3,4-b]pyrrol-3-yl]ethanone
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C14H17NO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000001 , Jurkat
 Cell Line Info 
Cell Line ID: CL000996 , RT-4
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0013421
 Compound Info 
CAS_97-39-2
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C15H17N3
  2
1 Ki = 18 nM
2 Ki = 28.4 nM
Clinical Information about the Protein
Target 1 ( Sigma intracellular receptor 2 (TMEM97) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Alzheimer disease [ICD-11: 8A20]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 CT1812
 Drug Info 
Phase 2
Alzheimer disease
Target 2 ( HUMAN sigma intracellular receptor 2 (TMEM97) )
Target Type Unknown Type Target
Disease 2 Target-related Diseases  2
1 Schizophrenia [ICD-11: 6A20]
2 Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y]
Investigative Drug(s) 2 Investigative Drugs  2
1 Haloperidol
 Drug Info 
Approved
Schizophrenia
2 PB28
 Drug Info 
Investigative
Coronavirus Disease 2019 (COVID-19)