General Information of the Protein
Protein ID
PT03480
Protein Name
Lysosomal alpha-mannosidase
Secondarily
Protein Name
Lysosomal acid alpha-mannosidase
Mannosidase alpha class 2B member 1
Mannosidase alpha-B
Gene Name
MAN2B1
Secondarily
Gene Name
LAMAN
MANB
Sequence
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages.
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Uniprot ID
Primary ID:
O00754

Secondarily ID:
G5E928
O15330
Q16680
Q93094
Q9BW13
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Ensembl ID
ENSG00000104774
HGNC ID
HGNC:6826
Subcellular Location
Lysosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000418 , LN-308
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0237947
 Compound Info 
(3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-phenylethylamino)methyl)-1-methylpyrrolidin-2-one
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C14H20N2O4
  2
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 550 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0281764
 Compound Info 
(R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate
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C21H23BrN2O5
  1
1
IC50 = 7500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0077627
 Compound Info 
(-)-swainsonine
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C8H15NO3
  1
1
IC50 = 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0237453
 Compound Info 
(3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-phenylethylamino)methyl)pyrrolidin-2-one
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C13H18N2O4
  1
1
IC50 = 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0237454
 Compound Info 
(2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL
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C13H20N2O3
  2
1
IC50 = 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 41500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0289178
 Compound Info 
(R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate
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C20H23BrN2O4
  1
1
IC50 = 75000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000424 , LN-18
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0077627
 Compound Info 
(-)-swainsonine
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C8H15NO3
  1
1 IC50 = 10 nM
CP0237947
 Compound Info 
(3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-phenylethylamino)methyl)-1-methylpyrrolidin-2-one
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C14H20N2O4
  2
1 IC50 = 500 nM
2 Ki = 670 nM
CP0281764
 Compound Info 
(R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate
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C21H23BrN2O5
  1
1 IC50 = 750 nM
CP0237454
 Compound Info 
(2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL
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C13H20N2O3
  2
1 IC50 = 25000 nM
2 Ki = 23300 nM
CP0237453
 Compound Info 
(3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-phenylethylamino)methyl)pyrrolidin-2-one
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C13H18N2O4
  1
1 IC50 = 75000 nM
CP0289178
 Compound Info 
(R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate
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C20H23BrN2O4
  1
1 IC50 = 75000 nM
Clinical Information about the Protein
Target 1 ( Lysosomal alpha-mannosidase (MAN2B1) )
Target Type Successful Target