General Information of the Protein
Protein ID
PT02824
Protein Name
Lysophosphatidic acid receptor 3
Secondarily
Protein Name
Lysophosphatidic acid receptor Edg-7
Gene Name
LPAR3
Secondarily
Gene Name
EDG7
LPA3
Sequence
MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
EDG receptor
Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
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Uniprot ID
Primary ID:
Q9UBY5

Secondarily ID:
A0AVA3
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HGNC ID
HGNC:14298
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000064 , Chem-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0169580
 Compound Info 
[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl] N-[3-methyl-5-[4-[4-[1-(methylsulfonylcarbamoyl)cyclopropyl]phenyl]phenyl]triazol-4-yl]carbamate
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C30H28F3N5O5S
  1
1
IC50 = 65 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0212474
 Compound Info 
1-[4-[4-[1-methyl-5-[[(1R)-1-[3-(trifluoromethyl)phenyl]ethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C29H25F3N4O4
  1
1
IC50 = 132 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0193811
 Compound Info 
1-[4-[4-[1-methyl-5-[[(1R)-1-[3-(trifluoromethyl)phenyl]ethoxy]carbonylamino]pyrazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C30H26F3N3O4
  1
1
IC50 = 478 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238378
 Compound Info 
1-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C28H26N4O4
  1
1
IC50 = 2290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0097125
 Compound Info 
[(1R)-1-phenylethyl] N-[3-methyl-5-[4-[4-[1-(methylsulfonylcarbamoyl)cyclopropyl]phenyl]phenyl]triazol-4-yl]carbamate
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C29H29N5O5S
  1
1
IC50 = 2310 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0282928
 Compound Info 
1-[4-[4-[5-[[(1R)-1-(2-fluorophenyl)ethoxy]carbonylamino]-1-methylpyrazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C29H26FN3O4
  1
1
IC50 = 5800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0241461
 Compound Info 
1-[4-[4-[1-methyl-5-[[(1S)-1-[3-(trifluoromethyl)phenyl]ethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C29H25F3N4O4
  1
1
IC50 = 6300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0342653
 Compound Info 
1-[4-[4-[4-methyl-5-[[(1R)-1-[3-(trifluoromethyl)phenyl]ethoxy]carbonylamino]triazol-1-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C29H25F3N4O4
  1
1
IC50 = 6860 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0193810
 Compound Info 
1-[4-[4-[5-[1-(4-fluorophenyl)ethoxycarbonylamino]-1-methylpyrazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C29H26FN3O4
  1
1
IC50 = 8260 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138967
 Compound Info 
1-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]pyrazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C29H27N3O4
  1
1
IC50 = 8340 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0212475
 Compound Info 
2-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-4-yl]phenyl]cyclohexyl]acetic acid
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C26H30N4O4
  1
1
IC50 = 18600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0323007
 Compound Info 
2-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]acetic acid
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C26H24N4O4
  1
1
IC50 = 21940 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169579
 Compound Info 
1-[4-[3-fluoro-4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C28H25FN4O4
  1
1
IC50 = 27350 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0085016
 Compound Info 
[(1R)-1-phenylethyl] N-[4-(4-methoxyphenyl)-2-methylpyrazol-3-yl]carbamate
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C20H21N3O3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169576
 Compound Info 
1-(2-chlorophenyl)ethyl N-(2-methyl-4-phenylpyrazol-3-yl)carbamate
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C19H18ClN3O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0212471
 Compound Info 
[(1R)-1-phenylethyl] N-[2-methyl-4-(4-phenylphenyl)pyrazol-3-yl]carbamate
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C25H23N3O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0212478
 Compound Info 
[(1R)-1-phenylethyl] N-(2-methyl-4-phenylpyrazol-3-yl)carbamate
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C19H19N3O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238372
 Compound Info 
1-(2-chlorophenyl)ethyl N-[4-(4-fluorophenyl)-2-methylpyrazol-3-yl]carbamate
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C19H17ClFN3O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238374
 Compound Info 
[(1S)-1-(2-chlorophenyl)ethyl] N-[4-(2-fluorophenyl)-2-methylpyrazol-3-yl]carbamate
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C19H17ClFN3O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238375
 Compound Info 
2-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]pyrazol-4-yl]phenyl]acetic acid
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C21H21N3O4
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0282927
 Compound Info 
2-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]pyrazol-4-yl]phenyl]phenyl]acetic acid
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C27H25N3O4
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0319928
 Compound Info 
ethyl 1-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]pyrazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylate
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C31H31N3O4
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0342651
 Compound Info 
[(1R)-1-(2-chlorophenyl)ethyl] N-[4-(2-fluorophenyl)-2-methylpyrazol-3-yl]carbamate
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C19H17ClFN3O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000466 , McA-RH7777
 Cell Line Info 
Cell Line ID: CL001056 , MEF-1 [Mouse fibroblast]
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0169580
 Compound Info 
[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl] N-[3-methyl-5-[4-[4-[1-(methylsulfonylcarbamoyl)cyclopropyl]phenyl]phenyl]triazol-4-yl]carbamate
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C30H28F3N5O5S
  1
1 IC50 = 65.7 nM
CP0212474
 Compound Info 
1-[4-[4-[1-methyl-5-[[(1R)-1-[3-(trifluoromethyl)phenyl]ethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C29H25F3N4O4
  1
1 IC50 = 132 nM
CP0238378
 Compound Info 
1-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C28H26N4O4
  1
1 IC50 = 2290 nM
CP0097125
 Compound Info 
[(1R)-1-phenylethyl] N-[3-methyl-5-[4-[4-[1-(methylsulfonylcarbamoyl)cyclopropyl]phenyl]phenyl]triazol-4-yl]carbamate
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C29H29N5O5S
  1
1 IC50 = 2310 nM
CP0241461
 Compound Info 
1-[4-[4-[1-methyl-5-[[(1S)-1-[3-(trifluoromethyl)phenyl]ethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C29H25F3N4O4
  1
1 IC50 = 6310 nM
CP0212475
 Compound Info 
2-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-4-yl]phenyl]cyclohexyl]acetic acid
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C26H30N4O4
  1
1 IC50 = 18640 nM
CP0323007
 Compound Info 
2-[4-[4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]acetic acid
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C26H24N4O4
  1
1 IC50 = 21940 nM
CP0169579
 Compound Info 
1-[4-[3-fluoro-4-[1-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
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C28H25FN4O4
  1
1 IC50 = 27350 nM
CP0166826
 Compound Info 
[(2R)-2-[[(Z)-octadec-9-enoyl]amino]-3-[4-(pyridin-2-ylmethoxy)phenyl]propyl] dihydrogen phosphate
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C33H51N2O6P
  1
1 Ki = 175 nM
CP0128457
 Compound Info 
2-(3-(4-nitrophenoxy)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid
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C21H12N2O7
  1
1 Ki = 230 nM
CP0099061
 Compound Info 
[(2S)-2-[[(Z)-octadec-9-enoyl]amino]-3-[4-(pyridin-2-ylmethoxy)phenyl]propyl] dihydrogen phosphate
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C33H51N2O6P
  1
1 Ki = 940 nM
CP0151570
 Compound Info 
2-(1,3-dioxo-5-(p-tolyloxy)isoindolin-2-yl)acetic acid
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C17H13NO5
  1
1 Ki = 1084 nM
Clinical Information about the Protein
Target 1 ( Lysophosphatidate-3 receptor (LPAR3) )
Target Type Clinical trial Target
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT06140 Lysophosphatidic acid receptor 3 Rattus norvegicus, Rat
 Protein Info