Protein Information

General Information of the Protein

Protein ID	PT02754
Protein Name	Glutamate receptor ionotropic, kainate 2
Secondarily Protein Name	Excitatory amino acid receptor 4 Glutamate receptor 6
Gene Name	GRIK2
Secondarily Gene Name	GLUR6
Sequence	MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Ion channel > Ligand-gated ion channel > Ionotropic glutamate receptor > Kainate receptor
Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). Modulates cell surface expression of NETO2 (By similarity). Show/Hide
Uniprot ID	Primary ID: Q13002 Secondarily ID: A6NMY9 B5MCV0 D7RWZ3 D7RWZ4 D7RWZ5 D7RWZ6 D7RWZ7 Q8WWS1 Q96KS6 Q96KS7 Q96KS8 Show/Hide
Ensembl ID	ENSG00000164418
HGNC ID	HGNC:4580
Subcellular Location	Cell membrane Postsynaptic cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0000105 Compound Info	(2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid Show/Hide	C10H15NO4	3
1	EC50 = 700 nM Bioactivity Info	TI LI LO TS
2	Ki = 32 nM Bioactivity Info	TI LI LO TS
3	Ki = 32.4 nM Bioactivity Info	TI LI LO TS
CP0377460 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(2-methoxyphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C15H19NO5	1
1	EC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0397866 Compound Info	(2S,4R)-4-allyl glutamate Show/Hide	C8H13NO4	2
1	EC50 = 8300 nM Bioactivity Info	TI LI LO TS
2	Ki = 1840 nM Bioactivity Info	TI LI LO TS
CP0002355 Compound Info	(2S)-2-aminopentanedioic acid Show/Hide	C5H9NO4	2
1	EC50 = 25000 nM Bioactivity Info	TI LI LO TS
2	Ki = 1106 nM Bioactivity Info	TI LI LO TS
CP0383813 Compound Info	2-Amino-4-but-2-enyl-pentanedioic acid(LY339180) Show/Hide	C9H15NO4	2
1	EC50 = 58300 nM Bioactivity Info	TI LI LO TS
2	Ki = 3258 nM Bioactivity Info	TI LI LO TS
CP0204536 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-chlorophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C14H16ClNO4	3
1	EC50 = 70800 nM Bioactivity Info	TI LI LO TS
2	Ki = 3859 nM Bioactivity Info	TI LI LO TS
3	Ki = 4649 nM Bioactivity Info	TI LI LO TS
CP0067501 Compound Info	(2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pentanedioic acid Show/Hide	C18H19NO4	5
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	Ki > 10000 nM Bioactivity Info	TI LI LO TS
3	Ki = 13723 nM Bioactivity Info	TI LI LO TS
4	Ki = 15406 nM Bioactivity Info	TI LI LO TS
5	Ki = 15410 nM Bioactivity Info	TI LI LO TS
CP0460278 Compound Info	(S)-2-Amino-4-cyclopentylidene-pentanedioic acid Show/Hide	C10H15NO4	2
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0378727 Compound Info	1-(3-bromophenyl)-3-[5-chloro-2-(1H-tetrazol-5-yl-phenyl]urea Show/Hide	C14H10BrClN6O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0162369 Compound Info	2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid Show/Hide	C14H10BrClN2O3	1
1	IC50 = 28000 nM Bioactivity Info	TI LI LO TS
CP0008315 Compound Info	2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfonic acid amide Show/Hide	C12H8N4O6S	1
1	IC50 = 29000 nM Bioactivity Info	TI LI LO TS
CP0051516 Compound Info	1-[5-chloro-2-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-3-(3-bromophenyl)urea Show/Hide	C15H10BrClN4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0312285 Compound Info	2-[3-(3-bromophenyl)ureido]-4-chlorobenzenesulfonic acid Show/Hide	C13H10BrClN2O4S	1
1	IC50 = 37000 nM Bioactivity Info	TI LI LO TS
CP0346386 Compound Info	2-[2-[(3-bromophenyl)carbamoylamino]-4-chlorophenyl]acetic acid Show/Hide	C15H12BrClN2O3	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0374730 Compound Info	4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid Show/Hide	C18H13ClN2O3	1
1	IC50 = 62000 nM Bioactivity Info	TI LI LO TS
CP0040797 Compound Info	(2S,4R)-2-Amino-4-methyl-pentanedioic acid Show/Hide	C6H11NO4	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0161087 Compound Info	(3S,4aR,6S,8aR)-6-[[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid Show/Hide	C16H24F2N2O4	1
1	Ki = 50 nM Bioactivity Info	TI LI LO TS
CP0470502 Compound Info	2-Amino-4-prop-2-ynyl-pentanedioic acid Show/Hide	C8H11NO4	1
1	Ki = 160 nM Bioactivity Info	TI LI LO TS
CP0397871 Compound Info	(2S,4R)-2-amino-4-[(Z)-3-phenylprop-2-enyl]pentanedioic acid Show/Hide	C14H17NO4	1
1	Ki = 339 nM Bioactivity Info	TI LI LO TS
CP0289436 Compound Info	(2S)-2-amino-4-methylidenepentanedioic acid Show/Hide	C6H9NO4	1
1	Ki = 450 nM Bioactivity Info	TI LI LO TS
CP0384180 Compound Info	2-Amino-4-(2-methyl-3-phenyl-allyl)-pentanedioic acid Show/Hide	C15H19NO4	1
1	Ki = 500 nM Bioactivity Info	TI LI LO TS
CP0483084 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-fluorophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C14H16FNO4	1
1	Ki = 559 nM Bioactivity Info	TI LI LO TS
CP0207002 Compound Info	(7-{3-[3-(4-Nitro-phenyl)-ureidomethyl]-pyrrol-1-yl}-2,3-dioxo-6-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetic acid Show/Hide	C23H17F3N6O7	1
1	Ki = 610 nM Bioactivity Info	TI LI LO TS
CP0448648 Compound Info	2-Amino-4-prop-2-ynyl-pentanedioic acid Show/Hide	C8H11NO4	1
1	Ki = 823 nM Bioactivity Info	TI LI LO TS
CP0394118 Compound Info	2-Amino-4-(3-phenyl-prop-2-ynyl)-pentanedioic acid Show/Hide	C14H15NO4	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0440472 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(3-chlorophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C14H16ClNO4	1
1	Ki = 1132 nM Bioactivity Info	TI LI LO TS
CP0200335 Compound Info	3-(6-Nitro-2,3-dioxo-7-pyrrol-1-yl-3,4-dihydro-2H-quinoxalin-1-yl)-propionic acid Show/Hide	C15H12N4O6	1
1	Ki = 1200 nM Bioactivity Info	TI LI LO TS
CP0397255 Compound Info	2-[6-nitro-2,3-dioxo-7-[3-[[4-(2-phenylethyl)piperazin-1-yl]methyl]pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid Show/Hide	C27H28N6O6	1
1	Ki = 1400 nM Bioactivity Info	TI LI LO TS
CP0479891 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(2-chlorophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C14H16ClNO4	1
1	Ki = 1404 nM Bioactivity Info	TI LI LO TS
CP0394121 Compound Info	2-Amino-4-but-2-ynyl-pentanedioic acid Show/Hide	C9H13NO4	1
1	Ki = 1456 nM Bioactivity Info	TI LI LO TS
CP0358589 Compound Info	2-[7-[3-(aminomethyl)pyrrol-1-yl]-6-nitro-2,3-dioxo-4H-quinoxalin-1-yl]acetic acid Show/Hide	C15H13N5O6	1
1	Ki = 1500 nM Bioactivity Info	TI LI LO TS
CP0448620 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(2,6-dichlorophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C14H15Cl2NO4	1
1	Ki = 1568 nM Bioactivity Info	TI LI LO TS
CP0448400 Compound Info	(2S,4R)-2-amino-4-[(E)-3-phenylprop-2-enyl]pentanedioic acid Show/Hide	C14H17NO4	1
1	Ki = 1580 nM Bioactivity Info	TI LI LO TS
CP0378015 Compound Info	(2S,4R)-4-propylglutamic acid Show/Hide	C8H15NO4	1
1	Ki = 2450 nM Bioactivity Info	TI LI LO TS
CP0392860 Compound Info	(S)-2-Amino-4-ethylidene-pentanedioic acid Show/Hide	C7H11NO4	1
1	Ki = 2500 nM Bioactivity Info	TI LI LO TS
CP0521133 Compound Info	2-Amino-4-(3-chloro-allyl)-pentanedioic acid Show/Hide	C8H12ClNO4	1
1	Ki = 2893 nM Bioactivity Info	TI LI LO TS
CP0429233 Compound Info	2-Amino-4-pent-2-enyl-pentanedioic acid Show/Hide	C10H17NO4	1
1	Ki = 2984 nM Bioactivity Info	TI LI LO TS
CP0457282 Compound Info	2-[6-nitro-2,3-dioxo-7-[3-[(4-phenylpiperidin-1-yl)methyl]pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid Show/Hide	C26H25N5O6	1
1	Ki = 3600 nM Bioactivity Info	TI LI LO TS
CP0453300 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-nitrophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C14H16N2O6	1
1	Ki = 3845 nM Bioactivity Info	TI LI LO TS
CP0331934 Compound Info	(6-Nitro-2,3-dioxo-7-pyrrol-1-yl-3,4-dihydro-2H-quinoxalin-1-yl)-acetic acid Show/Hide	C14H10N4O6	1
1	Ki = 3900 nM Bioactivity Info	TI LI LO TS
CP0465001 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(3,4-dichlorophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C14H15Cl2NO4	1
1	Ki = 3987 nM Bioactivity Info	TI LI LO TS
CP0451571 Compound Info	2-[7-[3-[(4-benzylpiperazin-1-yl)methyl]pyrrol-1-yl]-6-nitro-2,3-dioxo-4H-quinoxalin-1-yl]acetic acid Show/Hide	C26H26N6O6	1
1	Ki = 4100 nM Bioactivity Info	TI LI LO TS
CP0451519 Compound Info	(2S,4R)-2-amino-4-[(E)-3-naphthalen-1-ylprop-2-enyl]pentanedioic acid Show/Hide	C18H19NO4	1
1	Ki = 4366 nM Bioactivity Info	TI LI LO TS
CP0429172 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-methylphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C15H19NO4	1
1	Ki = 4375 nM Bioactivity Info	TI LI LO TS
CP0441737 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-cyanophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C15H16N2O4	1
1	Ki = 4491 nM Bioactivity Info	TI LI LO TS
CP0395504 Compound Info	2-Amino-4-but-2-enyl-pentanedioic acid Show/Hide	C9H15NO4	1
1	Ki = 5373 nM Bioactivity Info	TI LI LO TS
CP0510985 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-phenylphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C20H21NO4	1
1	Ki = 5650 nM Bioactivity Info	TI LI LO TS
CP0087609 Compound Info	1-(4-Carboxymethyl-7-nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxalin-6-yl)-1H-pyrrole-3-carboxylic acid Show/Hide	C15H10N4O8	1
1	Ki = 5800 nM Bioactivity Info	TI LI LO TS
CP0445213 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-methylsulfanylphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C15H19NO4S	1
1	Ki = 6024 nM Bioactivity Info	TI LI LO TS
CP0453155 Compound Info	(6-Nitro-2,3-dioxo-7-{3-[(3-phenyl-propylamino)-methyl]-pyrrol-1-yl}-3,4-dihydro-2H-quinoxalin-1-yl)-acetic acid Show/Hide	C24H23N5O6	1
1	Ki = 6200 nM Bioactivity Info	TI LI LO TS
CP0377076 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(3-methoxyphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C15H19NO5	1
1	Ki = 6349 nM Bioactivity Info	TI LI LO TS
CP0443663 Compound Info	2-Amino-4-hexyl-pentanedioic acid Show/Hide	C11H21NO4	1
1	Ki = 7207 nM Bioactivity Info	TI LI LO TS
CP0451510 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-bromophenyl)prop-2-enyl]pentanedioic acid Show/Hide	C14H16BrNO4	1
1	Ki = 7216 nM Bioactivity Info	TI LI LO TS
CP0458954 Compound Info	2-Amino-4-(2-chloro-allyl)-pentanedioic acid Show/Hide	C8H12ClNO4	1
1	Ki = 8250 nM Bioactivity Info	TI LI LO TS
CP0496520 Compound Info	(2S,4R)-2-Amino-4-(3-phenyl-propyl)-pentanedioic acid Show/Hide	C14H19NO4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0493034 Compound Info	(S)-2-Amino-4-[4,4-diphenyl-but-(Z)-ylidene]-pentanedioic acid Show/Hide	C21H23NO4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0451178 Compound Info	2-Amino-4-pent-2-ynyl-pentanedioic acid Show/Hide	C10H15NO4	1
1	Ki = 10247 nM Bioactivity Info	TI LI LO TS
CP0535176 Compound Info	(2S,4R)-2-amino-4-[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enyl]pentanedioic acid Show/Hide	C15H16F3NO5	1
1	Ki = 11185 nM Bioactivity Info	TI LI LO TS
CP0521148 Compound Info	2-Allyl-4-amino-pentanedioic acid Show/Hide	C8H13NO4	1
1	Ki = 13800 nM Bioactivity Info	TI LI LO TS
CP0496393 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C16H21NO6	1
1	Ki = 13949 nM Bioactivity Info	TI LI LO TS
CP0502051 Compound Info	(S)-2-Amino-4-[(E)-but-2-en-(Z)-ylidene]-pentanedioic acid Show/Hide	C9H13NO4	1
1	Ki = 16300 nM Bioactivity Info	TI LI LO TS
CP0399917 Compound Info	(S)-2-Amino-4-propylidene-pentanedioicacid Show/Hide	C8H13NO4	1
1	Ki = 18000 nM Bioactivity Info	TI LI LO TS
CP0515816 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-methoxyphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C15H19NO5	1
1	Ki = 22340 nM Bioactivity Info	TI LI LO TS
CP0873915 Compound Info	2-Amino-4-pent-2-enyl-pentanedioic acid Show/Hide	C10H17NO4	1
1	Ki = 22529 nM Bioactivity Info	TI LI LO TS
CP0398226 Compound Info	3-(7-{3-[(Benzyl-methyl-amino)-methyl]-pyrrol-1-yl}-6-nitro-2,3-dioxo-3,4-dihydro-2H-quinoxalin-1-yl)-propionic acid Show/Hide	C24H23N5O6	1
1	Ki = 23000 nM Bioactivity Info	TI LI LO TS
CP0501243 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-carboxyphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C15H17NO6	1
1	Ki = 27280 nM Bioactivity Info	TI LI LO TS
CP0429157 Compound Info	(2S,4R)-2-amino-4-[(E)-3-(4-propan-2-ylphenyl)prop-2-enyl]pentanedioic acid Show/Hide	C17H23NO4	1
1	Ki = 27532 nM Bioactivity Info	TI LI LO TS
CP0395220 Compound Info	2-[6-nitro-2,3-dioxo-7-[3-(piperidin-1-ylmethyl)pyrrol-1-yl]-4H-quinoxalin-1-yl]acetic acid Show/Hide	C20H21N5O6	1
1	Ki = 28000 nM Bioactivity Info	TI LI LO TS
CP0378229 Compound Info	(2S,4R)-4-pentylglutamic acid Show/Hide	C10H19NO4	1
1	Ki = 41152 nM Bioactivity Info	TI LI LO TS
CP0448863 Compound Info	2-Amino-4-(3-methyl-but-2-enyl)-pentanedioic acid Show/Hide	C10H17NO4	1
1	Ki = 42809 nM Bioactivity Info	TI LI LO TS
CP0397870 Compound Info	(2S,4R)-2-amino-4-[(E)-3-[4-(trifluoromethyl)phenyl]prop-2-enyl]pentanedioic acid Show/Hide	C15H16F3NO4	1
1	Ki = 43929 nM Bioactivity Info	TI LI LO TS
CP0501493 Compound Info	(S)-2-Amino-4-[2,2-dimethyl-cyclopent-(Z)-ylidene]-pentanedioic acid Show/Hide	C12H19NO4	1
1	Ki = 46300 nM Bioactivity Info	TI LI LO TS
CP0508637 Compound Info	(S)-2-Amino-4-butylidene-pentanedioic acid Show/Hide	C9H15NO4	1
1	Ki = 57200 nM Bioactivity Info	TI LI LO TS
CP0429234 Compound Info	2-Amino-4-hex-2-ynyl-pentanedioic acid Show/Hide	C11H17NO4	1
1	Ki = 68547 nM Bioactivity Info	TI LI LO TS
CP0376766 Compound Info	(2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioic acid Show/Hide	C9H15NO4	1
1	Ki = 82500 nM Bioactivity Info	TI LI LO TS
CP0391361 Compound Info	(S)-2-Amino-4-[1-cyclopentyl-meth-(E)-ylidene]-pentanedioic acid Show/Hide	C11H17NO4	1
1	Ki = 87600 nM Bioactivity Info	TI LI LO TS
CP0403533 Compound Info	(S)-2-Amino-4-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-pentanedioic acid Show/Hide	C14H15NO4	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0448006 Compound Info	(S)-2-Amino-4-(2,2-dimethyl-propylidene)-pentanedioic acid Show/Hide	C10H17NO4	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0488123 Compound Info	(S)-2-Amino-4-cyclobutylidene-pentanedioic acid Show/Hide	C9H13NO4	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0497639 Compound Info	(S)-2-Amino-4-[2,2-dimethyl-cyclopent-(E)-ylidene]-pentanedioic acid Show/Hide	C12H19NO4	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0502379 Compound Info	(S)-2-Amino-4-[4,4-diphenyl-but-(E)-ylidene]-pentanedioic acid Show/Hide	C21H23NO4	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0067501 Compound Info	(2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pentanedioic acid Show/Hide	C18H19NO4	1
1	EC50 > 100000 nM
CP0000105 Compound Info	(2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid Show/Hide	C10H15NO4	1
1	Ki = 53 nM
CP0002355 Compound Info	(2S)-2-aminopentanedioic acid Show/Hide	C5H9NO4	1
1	Ki = 1106 nM
CP0008315 Compound Info	2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfonic acid amide Show/Hide	C12H8N4O6S	1
1	Ki = 13200 nM
CP0067480 Compound Info	(3S,4aR,6R,8aR)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid Show/Hide	C13H21N5O2	1
1	Ki > 100000 nM

Clinical Information about the Protein

Target 1 ( Glutamate receptor ionotropic kainate 2 (GRIK2) )

Target Type	Literature-reported Target

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT02201	Glutamate receptor ionotropic, kainate 2	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han