General Information of the Compound
Compound ID
CP0448620
Compound Name
(2S,4R)-2-amino-4-[(E)-3-(2,6-dichlorophenyl)prop-2-enyl]pentanedioic acid
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Structure
Formula
C14H15Cl2NO4
Molecular Weight
332.183
Canonical SMILES
N[C@@H](C[C@@H](C\C=C\c1c(Cl)cccc1Cl)C(O)=O)C(O)=O
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InChI
InChI=1S/C14H15Cl2NO4/c15-10-5-2-6-11(16)9(10)4-1-3-8(13(18)19)7-12(17)14(20)21/h1-2,4-6,8,12H,3,7,17H2,(H,18,19)(H,20,21)/b4-1+/t8-,12+/m1/s1
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InChIKey
SUPABNAXCCLJMI-PRWSZKMTSA-N
Physicochemical Property
logP
2.8995
Rotatable Bonds
7
Heavy Atom Count
21
Polar Areas
100.62
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10520545
SID: 15546377
ChEMBL ID
CHEMBL59297
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01518, Glutamate receptor ionotropic, kainate 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 131 nM
   TI
   LI
   LO
   TS
Protein ID: PT02754, Glutamate receptor ionotropic, kainate 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1568 nM
   TI
   LI
   LO
   TS