General Information of the Protein
Protein ID
PT02647
Protein Name
Glutamate carboxypeptidase 2
Secondarily
Protein Name
Cell growth-inhibiting gene 27 protein
Folate hydrolase 1
Folylpoly-gamma-glutamate carboxypeptidase
Glutamate carboxypeptidase II
Membrane glutamate carboxypeptidase
N-acetylated-alpha-linked acidic dipeptidase I
Prostate-specific membrane antigen
Pteroylpoly-gamma-glutamate carboxypeptidase
Gene Name
FOLH1
Secondarily
Gene Name
FOLH
NAALAD1
PSM
PSMA
GIG27
Sequence
MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MH clan
>
Metallo protease M28 family
>
Metallo protease M28B subfamily
Function
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
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Uniprot ID
Primary ID:
Q04609

Secondarily ID:
A4UU12
A9CB79
B7Z312
B7Z343
D3DQS5
E9PDX8
O43748
Q16305
Q541A4
Q8TAY3
Q9NP15
Q9NYE2
Q9P1P8
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Ensembl ID
ENSG00000086205
HGNC ID
HGNC:3788
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000141 , LNCaP
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0938815
 Compound Info 
[800CW]AdamGPI Trimer
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C101H136N7Na4O42P3S4
  2
1
Activity = 0.4 nM
 Bioactivity Info 
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2
Kd = 0.5 nM
 Bioactivity Info 
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CP0384471
 Compound Info 
5-[((S)-3-{3-[5-tert-Butoxycarbonylamino-3,7-bis-(2-{(S)-1-carboxy-3-[(2,4-dicarboxy-butyl)-hydroxy-phosphinoyl]-propylcarbamoyl}-ethyl)-adamantan-1-yl]-propionylamino}-3-carboxy-propyl)-hydroxy-phosphinoyl]-4-carboxy-pentanoic acid
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C54H85N4O29P3
  3
1
Activity = 0.9 nM
 Bioactivity Info 
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2
Kd = 0.6 nM
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3
Kd = 0.8 nM
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CP0048821
 Compound Info 
(R,S)-2-phosphonomethylpentanedioic acid
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C6H11O7P
  5
1
IC50 = 1.1 nM
 Bioactivity Info 
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2
IC50 = 52 nM
 Bioactivity Info 
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3
Kd = 0.4 nM
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4
Ki = 0.4 nM
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5
Ki = 31.2 nM
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CP0436197
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(3-(4-bromophenyl)ureido)pentyl)ureido)pentanedioic Acid
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C19H25BrN4O8
  1
1
IC50 = 2 nM
 Bioactivity Info 
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CP0490170
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(4-chlorobenzylamino)pentyl)ureido)pentanedioic Acid
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C19H26ClN3O7
  1
1
IC50 = 2 nM
 Bioactivity Info 
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CP0529479
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(3-(4-fluorophenyl)ureido)pentyl)ureido)pentanedioic Acid
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C19H25FN4O8
  1
1
IC50 = 3 nM
 Bioactivity Info 
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CP0566779
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[[2-[5-[(2,4-dinitroanilino)methyl]-4-iodotriazol-1-yl]acetyl]amino]pentyl]carbamoylamino]pentanedioic acid
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C23H28IN9O12
  1
1
IC50 = 3 nM
 Bioactivity Info 
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CP0428742
 Compound Info 
(2S,4S)-2-fluoro-4-(phosphonomethyl)pentanedioic acid
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C6H10FO7P
  2
1
IC50 = 3.1 nM
 Bioactivity Info 
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2
Ki = 1.4 nM
 Bioactivity Info 
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CP0434579
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(3-(4-chlorophenyl)ureido)pentyl)ureido)pentanedioic Acid
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C19H25ClN4O8
  1
1
IC50 = 4 nM
 Bioactivity Info 
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CP0880776
 Compound Info 
rac-2-Fluoro-4-(phosphonomethyl)pentanedioic Acid
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C6H10FO7P
  2
1
IC50 = 6.8 nM
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2
Ki = 2.6 nM
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CP0413689
 Compound Info 
(2R,4S)-2-fluoro-4-(phosphonomethyl)pentanedioic acid
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C6H10FO7P
  2
1
IC50 = 8.1 nM
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2
Ki = 3.1 nM
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CP0265204
 Compound Info 
US9296708, 4, ARM-P4
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C29H42N8O15
  1
1
IC50 = 9 nM
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CP0402152
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(3-(4-iodophenyl)ureido)pentyl)ureido)pentanedioic Acid
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C19H25IN4O8
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0434580
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(4-iodophenylsulfonamido)pentyl)-ureido)pentanedioic Acid
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C18H24IN3O9S
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0502211
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(3-phenylureido)pentyl)ureido)pentanedioic Acid
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C19H26N4O8
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0558325
 Compound Info 
N-[(1S)-1-carboxy-5-[[2-[4-[2-[2-[2-[2-[2-[2-[2-[2-[(2,4-dinitrophenyl)azaniumyl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxymethyl]-5-iodotriazol-1-yl]acetyl]amino]pentyl]-N'-[(1S)-1,3-dicarboxypropyl]carbamimidate
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C39H60IN9O20
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0549315
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[[2-[4-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxymethyl]-5-iodotriazol-1-yl]acetyl]amino]pentyl]carbamoylamino]pentanedioic acid
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C31H44IN9O16
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0524168
 Compound Info 
(9S,13S)-1-(3-iodophenyl)-3,11-dioxo-2,4,10,12-tetraazapentadecane-9,13,15-tricarboxylic Acid
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C20H27IN4O8
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0464093
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[[2-[5-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxymethyl]-4-iodotriazol-1-yl]acetyl]amino]pentyl]carbamoylamino]pentanedioic acid
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C31H44IN9O16
  1
1
IC50 = 19 nM
 Bioactivity Info 
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CP0436169
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(4-iodobenzylamino)pentyl)ureido)-pentanedioic Acid
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C19H26IN3O7
  1
1
IC50 = 22 nM
 Bioactivity Info 
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CP0244034
 Compound Info 
US9296708, 6, ARM-P8
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C37H58N8O19
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0391570
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[4-[2-[2-[2-[2-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxymethyl]-5-iodotriazol-1-yl]pentyl]carbamoylamino]pentanedioic acid
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C37H57IN8O19
  1
1
IC50 = 24 nM
 Bioactivity Info 
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CP0549314
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[4-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxymethyl]-5-iodotriazol-1-yl]pentyl]carbamoylamino]pentanedioic acid
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C29H41IN8O15
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0490204
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(2-iodobenzylamino)pentyl)ureido)-pentanedioic Acid
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C19H26IN3O7
  1
1
IC50 = 37 nM
 Bioactivity Info 
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CP0490168
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(4-bromobenzylamino)pentyl)ureido)pentanedioic Acid
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C19H26BrN3O7
  1
1
IC50 = 43 nM
 Bioactivity Info 
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CP0446416
 Compound Info 
(2S,4R)-2-fluoro-4-(phosphonomethyl)pentanedioic acid
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C6H10FO7P
  2
1
IC50 = 55.9 nM
 Bioactivity Info 
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2
Ki = 22 nM
 Bioactivity Info 
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CP0459119
 Compound Info 
(2R,4R)-2-fluoro-4-(phosphonomethyl)pentanedioic acid
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C6H10FO7P
  2
1
IC50 = 89.4 nM
 Bioactivity Info 
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2
Ki = 36.4 nM
 Bioactivity Info 
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CP0571575
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[[2-[5-[2-[2-[2-[2-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxymethyl]-4-iodotriazol-1-yl]acetyl]amino]pentyl]carbamoylamino]pentanedioic acid
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C39H60IN9O20
  1
1
IC50 = 98 nM
 Bioactivity Info 
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CP0391572
 Compound Info 
(2S)-2-[[(1S)-5-[[2-[5-(aminomethyl)-4-iodotriazol-1-yl]acetyl]amino]-1-carboxypentyl]carbamoylamino]pentanedioic acid
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C17H26IN7O8
  1
1
IC50 = 123 nM
 Bioactivity Info 
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CP0403050
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(naphthalen-1-ylmethylamino)pentyl)-ureido)pentanedioic Acid
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C23H29N3O7
  1
1
IC50 = 154 nM
 Bioactivity Info 
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CP0503012
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(2-chlorobenzylamino)pentyl)ureido)pentanedioic Acid
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C19H26ClN3O7
  1
1
IC50 = 245 nM
 Bioactivity Info 
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CP0423134
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(3-chlorobenzylamino)pentyl)ureido)pentanedioic Acid
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C19H26ClN3O7
  1
1
IC50 = 277 nM
 Bioactivity Info 
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CP0436172
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(3-iodobenzylamino)pentyl)ureido)-pentanedioic Acid
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C19H26IN3O7
  1
1
IC50 = 443 nM
 Bioactivity Info 
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CP0360834
 Compound Info 
(S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)pentanedioic Acid
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C12H21N3O7
  1
1
IC50 = 498 nM
 Bioactivity Info 
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CP0427655
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-5-(4-fluorobenzylamino)pentyl)ureido)pentanedioic Acid
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C19H26FN3O7
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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CP0423135
 Compound Info 
(S)-2-(3-((S)-5-(Benzylamino)-1-carboxypentyl)ureido)pentanedioic Acid
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C19H27N3O7
  1
1
IC50 = 2960 nM
 Bioactivity Info 
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CP0502210
 Compound Info 
(S)-2-(3-(4-iodobenzyl)ureido)pentanedioic acid
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C13H15IN2O5
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0877828
 Compound Info 
[800RS]AdamGPI Trimer
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C91H120N6NaO32P3S
  2
1
Kd = 0.2 nM
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2
Kd = 0.3 nM
 Bioactivity Info 
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CP0492735
 Compound Info 
Boc-AdamGPI Trimer
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C60H96N5O30P3
  3
1
Kd = 0.4 nM
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2
Kd = 0.5 nM
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3
Kd = 0.7 nM
 Bioactivity Info 
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CP0877842
 Compound Info 
[800CW]AdamGPI Dimer
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C91H120N6Na4O34P2S4
  3
1
Kd = 1.3 nM
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2
Kd = 1.7 nM
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3
Kd = 1.9 nM
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CP0460071
 Compound Info 
2-({[(3S)-3-{3-[3-(6-{[(tert-butoxy)carbonyl]amino}hexanamido)-5-(2-{[(1S)-1-carboxy-3-[(2,4-dicarboxybutyl)(hydroxy)phosphoryl]propyl]carbamoyl}ethyl)-7-(3-oxopropyl)adamantan-1-yl]propanamido}-3-carboxypropyl](hydroxy)phosphoryl}methyl)pentanedioic acid
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C50H80N4O22P2
  2
1
Kd = 2.4 nM
 Bioactivity Info 
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2
Kd = 4.8 nM
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CP0865184
 Compound Info 
tetrasodium mono(1-(6-((1S)-1-carboxy-3-((2,4-dicarboxybutyl)(hydroxy)phosphoryl)propylamino)-6-oxohexyl)-2-((E)-2-((E)-3-((E)-2-(3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-enyl)vinyl)-3,3-dimethyl-3H-indolium-5-sulfonate)
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C56H66N3Na4O22PS4
  1
1
Kd = 3.6 nM
 Bioactivity Info 
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CP0865183
 Compound Info 
[800CW]Adam GPI Monomer
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C81H104N5Na4O26PS4
  1
1
Kd = 5.4 nM
 Bioactivity Info 
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CP0935442
 Compound Info 
[125I]-(2S)-2-(3-((1R)-1-carboxy-2-(1-((S)-5-carboxy-5-(2-(3-iodobenzamido)acetamido)pentyl)-2,5-dioxopyrrolidin-3-ylthio)ethyl)ureido)pentanedioic acid
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C28H34IN5O13S
  1
1
Kd = 7.8 nM
 Bioactivity Info 
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CP0412329
 Compound Info 
2-((((S)-3-amino-3-carboxypropyl)(hydroxy)phosphoryl)methyl)pentanedioic acid
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C10H18NO8P
  1
1
Kd = 10.5 nM
 Bioactivity Info 
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CP0384470
 Compound Info 
2-[((S)-3-{3-[5-(6-tert-Butoxycarbonylamino-hexanoylamino)-3,7-bis-(3-oxo-propyl)-adamantan-1-yl]-propionylamino}-3-carboxy-propyl)-hydroxy-phosphinoylmethyl]-pentanedioic acid
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C40H64N3O14P
  1
1
Kd = 16.4 nM
 Bioactivity Info 
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CP0900110
 Compound Info 
[125I]-(S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic acid
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C19H26IN3O7
  1
1
Kd = 20.4 nM
 Bioactivity Info 
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CP0900111
 Compound Info 
[125I]-(S)-2-(3-((S)-1-carboxy-2-(4-hydroxy-3-iodophenyl)ethyl)ureido)pentanedioic acid
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C15H17IN2O8
  1
1
Kd = 143 nM
 Bioactivity Info 
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CP0259703
 Compound Info 
2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedioic acid
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C12H20N2O7
  1
1
Ki = 1.08 nM
 Bioactivity Info 
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CP0389960
 Compound Info 
(2S)-2-[[(1R)-1-carboxy-2-[1-[(5S)-5-carboxy-5-[5-[(3-iodobenzoyl)amino]pentanoylamino]pentyl]-2,5-dioxopyrrolidin-3-yl]sulfanylethyl]carbamoylamino]pentanedioic acid
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C31H40IN5O13S
  1
1
Ki = 2.14 nM
 Bioactivity Info 
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CP0390038
 Compound Info 
(2S)-2-[[(1R)-1-carboxy-2-[1-[(5S)-5-carboxy-5-[(3-iodobenzoyl)amino]pentyl]-2,5-dioxopyrrolidin-3-yl]sulfanylethyl]carbamoylamino]pentanedioic acid
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C26H31IN4O12S
  1
1
Ki = 2.79 nM
 Bioactivity Info 
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CP0390039
 Compound Info 
(2S)-2-[[(1R)-1-carboxy-2-[1-[(5S)-5-carboxy-5-[4-[(3-iodobenzoyl)amino]butanoylamino]pentyl]-2,5-dioxopyrrolidin-3-yl]sulfanylethyl]carbamoylamino]pentanedioic acid
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C30H38IN5O13S
  1
1
Ki = 2.95 nM
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CP0484607
 Compound Info 
(2S)-2-[[(1R)-1-carboxy-2-[1-[(5S)-5-carboxy-5-[[2-[(3-iodobenzoyl)amino]acetyl]amino]pentyl]-2,5-dioxopyrrolidin-3-yl]sulfanylethyl]carbamoylamino]pentanedioic acid
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C28H34IN5O13S
  1
1
Ki = 4.97 nM
 Bioactivity Info 
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CP0484620
 Compound Info 
(2S)-2-[[(1R)-1-carboxy-2-[1-[(5S)-5-carboxy-5-[3-[(3-iodobenzoyl)amino]propanoylamino]pentyl]-2,5-dioxopyrrolidin-3-yl]sulfanylethyl]carbamoylamino]pentanedioic acid
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C29H36IN5O13S
  1
1
Ki = 6.26 nM
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CP0484621
 Compound Info 
(2S)-2-[[(1R)-1-carboxy-2-[1-[5-[[2-[(3-iodobenzoyl)amino]acetyl]amino]pentyl]-2,5-dioxopyrrolidin-3-yl]sulfanylethyl]carbamoylamino]pentanedioic acid
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C27H34IN5O11S
  1
1
Ki = 7.91 nM
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CP0553939
 Compound Info 
(2S)-2-[[(1R)-2-[1-[(5S)-5-[(2-benzamidoacetyl)amino]-5-carboxypentyl]-2,5-dioxopyrrolidin-3-yl]sulfanyl-1-carboxyethyl]carbamoylamino]pentanedioic acid
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C28H35N5O13S
  1
1
Ki = 8.06 nM
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CP0497199
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[(4-iodobenzoyl)amino]pentyl]carbamoylamino]heptanoic acid
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C21H30IN3O6
  1
1
Ki = 20 nM
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CP0161548
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-3-(methylthio)propyl)ureido)-6-(4-iodobenzamido)hexanoic acid
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C19H26IN3O6S
  1
1
Ki = 23 nM
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CP0476411
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[(4-iodobenzoyl)amino]pentyl]carbamoylamino]nonanoic acid
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C23H34IN3O6
  1
1
Ki = 29 nM
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CP0467426
 Compound Info 
(2S)-2-[[(1S)-1-carboxypentyl]carbamoylamino]-6-[(4-iodobenzoyl)amino]hexanoic acid
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C20H28IN3O6
  1
1
Ki = 56 nM
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CP0574203
 Compound Info 
(2S)-2-[[(1R)-1-carboxy-2-(1-methyl-2,5-dioxopyrrolidin-3-yl)sulfanylethyl]carbamoylamino]pentanedioic acid
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C14H19N3O9S
  1
1
Ki = 62.1 nM
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CP0503020
 Compound Info 
(2S)-2-[[(1S)-1-carboxy-5-[(4-iodobenzoyl)amino]pentyl]carbamoylamino]octanoic acid
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C22H32IN3O6
  1
1
Ki = 72 nM
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CP0452557
 Compound Info 
2-(4-Hydroxy-3-methoxyphenyl)-2-(3-((S)-1-isopropoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
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C19H28N2O7
  1
1
Ki = 81 nM
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CP0446987
 Compound Info 
(2S)-2-[[(1R)-1-carboxy-2-[1-[(5S)-5-carboxy-5-[[2-(methylamino)acetyl]amino]pentyl]-2,5-dioxopyrrolidin-3-yl]sulfanylethyl]carbamoylamino]pentanedioic acid
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C22H33N5O12S
  1
1
Ki = 94.8 nM
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CP0495021
 Compound Info 
(2S)-2-[[(1S)-1-carboxypropyl]carbamoylamino]-6-[(4-iodobenzoyl)amino]hexanoic acid
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C18H24IN3O6
  1
1
Ki = 121 nM
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CP0332076
 Compound Info 
(S)-2-(3-((S)-1-Carboxybutyl)ureido)-6-(4-iodobenzamido)hexanoic acid
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C19H26IN3O6
  1
1
Ki = 145 nM
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CP0527075
 Compound Info 
2-(4-Hydroxy-3-methoxyphenyl)-2-(3-((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
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C17H24N2O7
  1
1
Ki = 153 nM
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CP0375600
 Compound Info 
(S)-2-(3-(Carboxy(4-hydroxy-3-methoxyphenyl)methyl)ureido)-4-methylpentanoic acid
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C16H22N2O7
  1
1
Ki = 250 nM
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CP0381152
 Compound Info 
2-(4-Hydroxy-3-iodophenyl)-2-(3-((S)-1-isopropoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
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C18H25IN2O6
  1
1
Ki = 275 nM
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CP0540045
 Compound Info 
(2S)-2-[[(1S)-1-carboxyethyl]carbamoylamino]-6-[(4-iodobenzoyl)amino]hexanoic acid
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C17H22IN3O6
  1
1
Ki = 325 nM
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CP0164325
 Compound Info 
2-[3-(1-Carboxy-2-mercapto-ethyl)-ureido]-pentanedioic acid
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C9H14N2O7S
  1
1
Ki = 376 nM
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CP0494466
 Compound Info 
(S)-2-(3-bromo-4-hydroxyphenyl)-2-(3-((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
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C16H21BrN2O6
  1
1
Ki = 400 nM
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CP0375601
 Compound Info 
(S)-2-(4-Hydroxy-3-iodophenyl)-2-(3-((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
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C16H21IN2O6
  1
1
Ki = 475 nM
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CP0375602
 Compound Info 
(S)-2-(3,5-dibromo-4-hydroxyphenyl)-2-(3-((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
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C16H20Br2N2O6
  1
1
Ki = 575 nM
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CP0510427
 Compound Info 
2-(3-(1-Carboxy-2-(4-hydroxyphenyl)ethyl)ureido)-4-methylpentanoic acid
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C16H22N2O6
  1
1
Ki = 700 nM
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CP0458866
 Compound Info 
(S)-2-(3-((S)-carboxy(4-hydroxyphenyl)methyl)ureido)-4-methylpentanoic acid
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C15H20N2O6
  1
1
Ki = 775 nM
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CP0428954
 Compound Info 
(S)-3-(2-Carboxy-2-(3-(1-carboxy-3-methylbutyl)ureido)ethyl)benzoic acid
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C17H22N2O7
  1
1
Ki = 3000 nM
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CP0526811
 Compound Info 
(S)-2-(3-Fluoro-4-hydroxyphenyl)-2-(3-(1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
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C16H21FN2O6
  1
1
Ki = 3000 nM
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CP0526813
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-3-(methylthio)propyl)ureido)-4-methylpentanoic acid
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C13H24N2O5S
  1
1
Ki = 3500 nM
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CP0151000
 Compound Info 
(S)-2-(3-(Carboxymethyl)ureido)-6-(4-iodobenzamido)hexanoic acid
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C16H20IN3O6
  1
1
Ki = 4390 nM
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CP0507507
 Compound Info 
(S)-5-amino-2-(3-((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)-5-oxopentanoic acid
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C14H25N3O6
  1
1
Ki = 7500 nM
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CP0470456
 Compound Info 
2-(3-(1-Carboxy-2-(4-hydroxy-3-iodophenyl)ethyl)ureido)-4-methylpentanoic acid
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C16H21IN2O6
  1
1
Ki = 13000 nM
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CP0496942
 Compound Info 
(2S)-2-(3-(carboxy(3,5-dihydroxyphenyl)methyl)ureido)-4-methylpentanoic acid
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C15H20N2O7
  1
1
Ki = 13000 nM
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Cell Line ID: CL000048 , PC-3
 Cell Line Info 
Cell Line ID: CL000090 , Schneider 2
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0048821
 Compound Info 
(R,S)-2-phosphonomethylpentanedioic acid
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C6H11O7P
  6
1 EC50 = 0.62 nM
2 IC50 = 0.3 nM
3 IC50 = 80 nM
4 Ki = 0.2 nM
5 Ki = 0.28 nM
6 Ki = 0.3 nM
CP0086026
 Compound Info 
(S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-pentanedioic acid
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C11H16N2O9
  2
1 IC50 = 47 nM
2 Ki = 8 nM
CP0360834
 Compound Info 
(S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)pentanedioic Acid
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C12H21N3O7
  2
1 IC50 = 547 nM
2 Ki = 44.3 nM
CP0204271
 Compound Info 
(2S)-2-(phosphonomethyl)pentanedioic acid
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C6H11O7P
  2
1 Ki = 0.1 nM
2 Ki = 0.3 nM
CP0259703
 Compound Info 
2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedioic acid
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C12H20N2O7
  2
1 Ki = 0.58 nM
2 Ki = 0.75 nM
CP0161548
 Compound Info 
(S)-2-(3-((S)-1-Carboxy-3-(methylthio)propyl)ureido)-6-(4-iodobenzamido)hexanoic acid
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C19H26IN3O6S
  1
1 Ki = 23 nM
CP0332076
 Compound Info 
(S)-2-(3-((S)-1-Carboxybutyl)ureido)-6-(4-iodobenzamido)hexanoic acid
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C19H26IN3O6
  1
1 Ki = 52.3 nM
CP0151000
 Compound Info 
(S)-2-(3-(Carboxymethyl)ureido)-6-(4-iodobenzamido)hexanoic acid
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C16H20IN3O6
  1
1 Ki = 1320 nM
CP0217178
 Compound Info 
(2S)-2-[(3S)-3-acetamido-3-formamidopropanoic acid]pentanedioic acid
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C11H16N2O8
  1
1 Km = 1200 nM
Clinical Information about the Protein
Target 1 ( Glutamate carboxypeptidase II (GCPII) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Prostate cancer [ICD-11: 2C82.0]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 MIP-1095
 Drug Info 
Phase 1
Prostate cancer