General Information of the Protein
Protein ID |
PT02528
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Protein Name |
Sodium- and chloride-dependent GABA transporter 1
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Secondarily Protein Name |
Solute carrier family 6 member 1
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Gene Name |
SLC6A1
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Secondarily Gene Name |
GABATR
GABT1
GAT1
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Sequence |
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
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Organism |
Homo sapiens, Human
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Protein Classification |
Transporter
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Electrochemical transporter
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SLC superfamily of solute carriers
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SLC06 neurotransmitter transporter family
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Function |
Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity).
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Uniprot ID |
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Ensembl ID | |||||
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Subcellular Location |
Cell membrane
Presynapse
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Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Cell Line ID: CL000880 , COS
Cell Line ID: CL000386 , Flp-In-CHO
Cell Line ID: CL000006 , HEK293
Cell Line ID: CL000027 , tsA201
Biochemical Assays
Clinical Information about the Protein
Target 1 ( GABA transporter GAT-1 (SLC6A1) )
Target Type | Successful Target | ||||
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Disease | 3 Target-related Diseases | 3 | |||
1 | Epilepsy [ICD-11: 8A60-8A68] | ||||
2 | Inflammatory bowel disease [ICD-11: DD72] | ||||
3 | Convulsion [ICD-11: 8A68.Z] | ||||
Approved Drug(s) | 1 Approved Drug | 1 | |||
1 | Tiagabine | Approved | |||
Clinical Trial Drug(s) | 2 Clinical Trial Drugs | 2 | |||
1 | GSK683699 | Phase 2 | |||
2 | CI-966 | Phase 1 |