General Information of the Protein
Protein ID
PT02182
Protein Name
AP2-associated protein kinase 1
Secondarily
Protein Name
Adaptor-associated kinase 1
Gene Name
AAK1
Secondarily
Gene Name
KIAA1048
Sequence
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Other protein kinase group
>
Other protein kinase NAK family
Function
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:17494869, PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124).
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Uniprot ID
Primary ID:
Q2M2I8

Secondarily ID:
Q4ZFZ3
Q53RX6
Q9UPV4
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Ensembl ID
ENSG00000115977
HGNC ID
HGNC:19679
Subcellular Location
Cell membrane
Membrane
Clathrin-coated pit
Presynapse
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0519352
 Compound Info 
N-[6-[3-(cyclobutylsulfonylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H22N4O3S
  1
1
IC50 = 192 nM
 Bioactivity Info 
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CP0542395
 Compound Info 
N-[6-[3-[[ethyl(methyl)sulfamoyl]amino]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C20H23N5O3S
  1
1
IC50 = 375 nM
 Bioactivity Info 
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CP0423041
 Compound Info 
N-[6-[3-[(3-fluorophenyl)methylsulfonylamino]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C24H21FN4O3S
  1
1
IC50 = 379 nM
 Bioactivity Info 
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CP0555200
 Compound Info 
N-[6-[3-(2-methylpropylsulfonylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H24N4O3S
  1
1
IC50 = 490 nM
 Bioactivity Info 
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CP0474150
 Compound Info 
N-[6-[3-[(2-fluorophenyl)methylsulfonylamino]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C24H21FN4O3S
  1
1
IC50 = 528 nM
 Bioactivity Info 
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CP0423046
 Compound Info 
N-[6-[3-(cyclopropylsulfonylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C20H20N4O3S
  1
1
IC50 = 641 nM
 Bioactivity Info 
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CP0489852
 Compound Info 
N-[6-[3-(propylsulfonylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C20H22N4O3S
  1
1
IC50 = 655 nM
 Bioactivity Info 
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CP0469511
 Compound Info 
N-[6-[3-(diethylsulfamoylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H25N5O3S
  1
1
IC50 = 770 nM
 Bioactivity Info 
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CP0423044
 Compound Info 
N-[6-[3-[(4-fluorophenyl)methylsulfonylamino]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C24H21FN4O3S
  1
1
IC50 = 1020 nM
 Bioactivity Info 
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CP0423045
 Compound Info 
N-[6-[3-[(cyclopropylmethylsulfonylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C22H24N4O3S
  1
1
IC50 = 1260 nM
 Bioactivity Info 
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CP0555201
 Compound Info 
N-[6-[3-[(diethylsulfamoylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C22H27N5O3S
  1
1
IC50 = 1470 nM
 Bioactivity Info 
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CP0423043
 Compound Info 
N-[6-[3-[(2-methylpropylsulfonylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C22H26N4O3S
  1
1
IC50 = 1530 nM
 Bioactivity Info 
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CP0474151
 Compound Info 
N-[6-[3-[[[ethyl(methyl)sulfamoyl]amino]methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H25N5O3S
  1
1
IC50 = 1790 nM
 Bioactivity Info 
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CP0519634
 Compound Info 
N-[6-[3-[(2,2,2-trifluoroethylsulfonylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C20H19F3N4O3S
  1
1
IC50 = 2350 nM
 Bioactivity Info 
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CP0489853
 Compound Info 
N-[6-[3-[(3,3,3-trifluoropropylsulfonylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H21F3N4O3S
  1
1
IC50 = 2710 nM
 Bioactivity Info 
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CP0423042
 Compound Info 
N-[6-[3-[[[methyl(2,2,2-trifluoroethyl)sulfamoyl]amino]methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H22F3N5O3S
  1
1
IC50 = 3400 nM
 Bioactivity Info 
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Cell Line ID: CL000131 , HEK293-F
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0545257
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-cyanophenyl)pyridin-2-yl)acetamide
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C20H24N4O2
  1
1 IC50 = 0.3 nM
CP0579391
 Compound Info 
(S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(trifluoromethyl)phenyl)pyridin-2-yl)carbamate
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C21H26F3N3O3
  1
1 IC50 = 0.3 nM
CP0261910
 Compound Info 
(S)-1-(2-(difluoromethyl)-4-(2-methylpyridin-4-yl)phenoxy)-2,4-dimethylpentan-2-amine
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C20H26F2N2O
  1
1 IC50 = 0.4 nM
CP0261912
 Compound Info 
(S)-1-(2-(difluoromethyl)-4-(2-(difluoromethyl)pyridin-4-yl)phenoxy)-2,4-dimethylpentan-2-amine
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C20H24F4N2O
  1
1 IC50 = 0.4 nM
CP0570410
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifluoromethyl)phenyl)pyridin-2-yl)acetamide
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C20H24F3N3O2
  1
1 IC50 = 0.4 nM
CP0572846
 Compound Info 
(S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-(trifluoromethyl)-[2,4&#8242;-bipyridin]-2&#8242;-yl)carbamate
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C20H25F3N4O3
  1
1 IC50 = 0.4 nM
CP0574558
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-methylphenyl)pyridin-2-yl)acetamide
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C20H27N3O2
  1
1 IC50 = 0.4 nM
CP0576653
 Compound Info 
(S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(trifluoromethyl)phenyl)pyridin-2-yl)acetamide
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C21H26F3N3O2
  1
1 IC50 = 0.4 nM
CP0578064
 Compound Info 
(S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-cyclopropylphenyl)pyridin-2-yl)carbamate
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C23H31N3O3
  1
1 IC50 = 0.4 nM
CP0579172
 Compound Info 
methyl N-[4-[6-[(2S)-2-amino-2,4-dimethylpentoxy]-5-chloropyridin-3-yl]pyridin-2-yl]carbamate
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C19H25ClN4O3
  1
1 IC50 = 0.4 nM
CP0550190
 Compound Info 
(S)-1-((4-(difluoromethyl)-2&#8242;-methyl-[2,4&#8242;-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
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C19H25F2N3O
  1
1 IC50 = 0.5 nM
CP0550222
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-chlorophenyl)pyridin-2-yl)acetamide
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C19H24ClN3O2
  1
1 IC50 = 0.5 nM
CP0574559
 Compound Info 
methyl N-[4-[4-[(2S)-2-amino-2,4-dimethylpentoxy]-3-chlorophenyl]pyridin-2-yl]carbamate
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C20H26ClN3O3
  1
1 IC50 = 0.5 nM
CP0576652
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetamide
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C20H24F3N3O3
  1
1 IC50 = 0.5 nM
CP0579169
 Compound Info 
(S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-cyanophenyl)pyridin-2-yl)carbamate
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C21H26N4O3
  1
1 IC50 = 0.5 nM
CP0579170
 Compound Info 
(S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(difluoromethyl)phenyl)pyridin-2-yl)carbamate
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C21H27F2N3O3
  1
1 IC50 = 0.5 nM
CP0579392
 Compound Info 
(S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-chloro-[2,4&#8242;-bipyridin]-2&#8242;-yl)carbamate
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C19H25ClN4O3
  1
1 IC50 = 0.5 nM
CP0261911
 Compound Info 
(S)-2,4-dimethyl-1-(4-(pyridin-4-yl)-2-(trifluoromethyl)phenoxy)pentan-2-amine
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C19H23F3N2O
  1
1 IC50 = 0.6 nM
CP0275628
 Compound Info 
(S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifluoromethyl)phenoxy)-2,4-dimethylpentan-2-amine
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C20H23F5N2O
  1
1 IC50 = 0.6 nM
CP0578664
 Compound Info 
(S)-2-((2-amino-2,4-dimethylpentyl)oxy)-5-(2-(difluoromethyl)pyridin-4-yl)benzonitrile
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C20H23F2N3O
  1
1 IC50 = 0.6 nM
CP0568346
 Compound Info 
(S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-cyanophenyl)pyridin-2-yl)acetamide
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C21H26N4O2
  1
1 IC50 = 0.6 nM
CP0570130
 Compound Info 
(S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(trifluoromethoxy)phenyl)pyridin-2-yl)carbamate
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C21H26F3N3O4
  1
1 IC50 = 0.6 nM
CP0579819
 Compound Info 
(S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(difluoromethyl)phenyl)pyridin-2-yl)acetamide
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C21H27F2N3O2
  1
1 IC50 = 0.6 nM
CP0575064
 Compound Info 
(S)-1-(2-cyclopropyl-4-(2-(difluoromethyl)pyridin-4-yl)phenoxy)-2,4-dimethylpentan-2-amine
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C22H28F2N2O
  1
1 IC50 = 0.7 nM
CP0549612
 Compound Info 
(S)-2-((2-amino-4-methylpentyl)oxy)-5-(2-methylpyridin-4-yl)benzonitrile
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C19H23N3O
  1
1 IC50 = 0.8 nM
CP0545258
 Compound Info 
(S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-fluorophenyl)pyridin-2-yl)acetamide
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C20H26FN3O2
  1
1 IC50 = 0.8 nM
CP0550224
 Compound Info 
(S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetamide
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C21H26F3N3O3
  1
1 IC50 = 0.8 nM
CP0576581
 Compound Info 
(S)-methyl (4-(4-((2-amino-4-methylpentyl)oxy)-3-(isoxazol-5-yl)phenyl)pyridin-2-yl)carbamate
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C22H26N4O4
  1
1 IC50 = 0.8 nM
CP0576583
 Compound Info 
methyl N-[4-[4-[(2S)-2-amino-2,4-dimethylpentoxy]-3-methylphenyl]pyridin-2-yl]carbamate
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C21H29N3O3
  1
1 IC50 = 0.8 nM
CP0578065
 Compound Info 
(S)-1-((2&#8242;-chloro-4-(difluoromethyl)-[2,4&#8242;-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
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C18H22ClF2N3O
  1
1 IC50 = 0.8 nM
CP0261909
 Compound Info 
(S)-2,4-dimethyl-1-(4-(2-methylpyridin-4-yl)-2-(trifluoromethyl)phenoxy)pentan-2-amine
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C20H25F3N2O
  1
1 IC50 = 0.9 nM
CP0568314
 Compound Info 
methyl N-[4-[6-[(2S)-2-amino-2,4-dimethylpentoxy]-5-methylpyridin-3-yl]pyridin-2-yl]carbamate
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C20H28N4O3
  1
1 IC50 = 0.9 nM
CP0576582
 Compound Info 
(S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-fluorophenyl)pyridin-2-yl)carbamate
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C20H26FN3O3
  1
1 IC50 = 1.1 nM
CP0576584
 Compound Info 
(S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-methyl-[2,4&#8242;-bipyridin]-2&#8242;-yl)carbamate
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C20H28N4O3
  1
1 IC50 = 1.1 nM
CP0569337
 Compound Info 
(S)-1-((2&#8242;,4-bis(difluoromethyl)-[2,4&#8242;-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
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C19H23F4N3O
  1
1 IC50 = 1.2 nM
CP0580159
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-2,5-difluorophenyl)pyridin-2-yl)acetamide
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C19H23F2N3O2
  1
1 IC50 = 1.3 nM
CP0579173
 Compound Info 
(S)-1-((2&#8242;-(difluoromethyl)-4-methyl-[2,4&#8242;-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
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C19H25F2N3O
  1
1 IC50 = 1.4 nM
CP0580026
 Compound Info 
(S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-methyl-[2,4&#8242;-bipyridin]-2&#8242;-yl)carbamate
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C20H28N4O3
  1
1 IC50 = 1.7 nM
CP0261975
 Compound Info 
(S)-1-((2&#8242;,6-bis(difluoromethyl)-[2,4&#8242;-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
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C19H23F4N3O
  1
1 IC50 = 2 nM
CP0970190
 Compound Info 
(S)-1-((4-chloro-2'-methyl-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
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C18H24ClN3O
  1
1 IC50 = 2.1 nM
CP0573765
 Compound Info 
(S)-1-(4-(2-fluoropyridin-4-yl)-2-(trifluoromethyl)phenoxy)-2,4-dimethylpentan-2-amine
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C19H22F4N2O
  1
1 IC50 = 2.2 nM
CP0575063
 Compound Info 
(S)-1-(2-cyclopropyl-4-(2-methylpyridin-4-yl)phenoxy)-2,4-dimethylpentan-2-amine
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C22H30N2O
  1
1 IC50 = 2.3 nM
CP0578035
 Compound Info 
(2S)-1-[5-[2-(difluoromethyl)pyridin-4-yl]-3-methylpyridin-2-yl]oxy-2,4-dimethylpentan-2-amine
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C19H25F2N3O
  1
1 IC50 = 2.5 nM
CP0579168
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-fluorophenyl)pyridin-2-yl)acetamide
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C19H24FN3O2
  1
1 IC50 = 2.6 nM
CP0574806
 Compound Info 
(S)-1-((6-(difluoromethyl)-2&#8242;-methyl-[2,4&#8242;-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
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C19H25F2N3O
  1
1 IC50 = 2.9 nM
CP0578755
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-methoxyphenyl)pyridin-2-yl)acetamide
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C20H27N3O3
  1
1 IC50 = 3 nM
CP0575065
 Compound Info 
(S)-1-((2&#8242;-chloro-5-(difluoromethyl)-[3,4&#8242;-bipyridin]-6-yl)oxy)-2,4-dimethylpentan-2-amine
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C18H22ClF2N3O
  1
1 IC50 = 3.1 nM
CP0579654
 Compound Info 
2-[(1S)-1-amino-3-methylbutyl]-6-(1,3-oxazol-5-yl)quinoline-4-carbonitrile
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C18H18N4O
  1
1 IC50 = 4.2 nM
CP0569336
 Compound Info 
(S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(hydroxymethyl)phenyl)pyridin-2-yl)carbamate
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C21H29N3O4
  1
1 IC50 = 4.5 nM
CP0580012
 Compound Info 
methyl N-[4-[4-[(2S)-2-amino-2,4-dimethylpentoxy]-2,3-dimethylphenyl]pyridin-2-yl]carbamate
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C22H31N3O3
  1
1 IC50 = 4.5 nM
CP0543984
 Compound Info 
(S)-2-((2-amino-2,4-dimethylpentyl)oxy)-5-(2-methylpyridin-4-yl)benzonitrile
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C20H25N3O
  1
1 IC50 = 4.6 nM
CP0576578
 Compound Info 
N-[4-[4-[(2S)-2-amino-4-methylpentoxy]phenyl]pyridin-2-yl]acetamide
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C19H25N3O2
  1
1 IC50 = 4.6 nM
CP0576580
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-fluoro-5-(trifluoromethyl)phenyl)pyridin-2-yl)acetamide
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C20H23F4N3O2
  1
1 IC50 = 5 nM
CP0578081
 Compound Info 
2-[(1S)-1-amino-3-methylbutyl]-6-pyridin-4-ylquinoline-4-carbonitrile
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C20H20N4
  1
1 IC50 = 5.8 nM
CP0548386
 Compound Info 
(2R,3R)-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-propan-2-ylpiperidine-2-carboxamide
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C19H25N3O3
  1
1 IC50 = 10 nM
CP0489392
 Compound Info 
(2S)-1-[5-(2-chloropyridin-4-yl)-3-methylpyridin-2-yl]oxy-2,4-dimethylpentan-2-amine
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C18H24ClN3O
  1
1 IC50 = 10 nM
CP0572127
 Compound Info 
(S)-2-((2-amino-4-methylpentyl)oxy)-5-(2-methoxypyridin-4-yl)benzonitrile
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C19H23N3O2
  1
1 IC50 = 10 nM
CP0576579
 Compound Info 
(S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-chloro-5-fluorophenyl)pyridin-2-yl)acetamide
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C19H23ClFN3O2
  1
1 IC50 = 10 nM
CP0576663
 Compound Info 
2-[(1R)-1-amino-3-methylbutyl]-6-pyridin-4-ylquinoline-4-carbonitrile
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C20H20N4
  1
1 IC50 = 11 nM
CP0268029
 Compound Info 
(2R)-2-amino-N-[3-(difluoromethoxy)-4-(1,3-oxazol-5-yl)phenyl]-4-methylpentanamide
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C16H19F2N3O3
  1
1 IC50 = 12 nM
CP0565309
 Compound Info 
(2R)-2-amino-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-4-methylpentanamide
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C16H21N3O3
  1
1 IC50 = 12 nM
CP0580042
 Compound Info 
(1S)-1-[4-ethyl-7-methoxy-6-(1,3-oxazol-5-yl)quinazolin-2-yl]-3-methylbutan-1-amine
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C19H24N4O2
  1
1 IC50 = 12 nM
CP0726102
 Compound Info 
(R)-2-Amino-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)-4-methylpentanamide
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C16H22N4O2
  1
1 IC50 = 15 nM
CP0572128
 Compound Info 
(2S)-1-[3-chloro-5-(2-methylpyridin-4-yl)pyridin-2-yl]oxy-2,4-dimethylpentan-2-amine
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C18H24ClN3O
  1
1 IC50 = 30 nM
CP0580223
 Compound Info 
(1S)-1-[4-ethyl-6-(1,3-oxazol-5-yl)quinazolin-2-yl]-3-methylbutan-1-amine
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C18H22N4O
  1
1 IC50 = 30 nM
CP0550932
 Compound Info 
(2S)-4-methyl-1-(4-pyridin-4-ylphenoxy)pentan-2-amine
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C17H22N2O
  1
1 IC50 = 49 nM
CP0543983
 Compound Info 
(S)-2-((2-amino-4-methylpentyl)oxy)-5-(2-(trifluoromethyl)pyridin-4-yl)benzonitrile
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C19H20F3N3O
  1
1 IC50 = 51 nM
CP0489393
 Compound Info 
(S)-1-((6-chloro-2&#8242;-methyl-[2,4&#8242;-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
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C18H24ClN3O
  1
1 IC50 = 73 nM
CP0469511
 Compound Info 
N-[6-[3-(diethylsulfamoylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H25N5O3S
  3
1 Kd = 9.1 nM
2 Kd = 26 nM
3 Ki = 9.1 nM
CP0002211
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
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C22H27FN4O2
  2
1 Kd = 11 nM
2 Kd = 130 nM
Clinical Information about the Protein
Target 1 ( Adaptor-associated kinase 1 (AAK1) )
Target Type Clinical trial Target
Target 2 ( HUMAN adaptor-associated kinase 1 (AAK1) )
Target Type Unknown Type Target
Disease 1 Target-related Disease  1
1 Rheumatoid arthritis [ICD-11: FA20]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Baricitinib
 Drug Info 
Approved
Rheumatoid arthritis