General Information of the Compound
Compound ID
CP0575063
Compound Name
(S)-1-(2-cyclopropyl-4-(2-methylpyridin-4-yl)phenoxy)-2,4-dimethylpentan-2-amine
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Structure
Formula
C22H30N2O
Molecular Weight
338.495
Canonical SMILES
CC(C)C[C@](C)(N)COc1ccc(cc1C1CC1)-c1ccnc(C)c1
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InChI
InChI=1S/C22H30N2O/c1-15(2)13-22(4,23)14-25-21-8-7-18(12-20(21)17-5-6-17)19-9-10-24-16(3)11-19/h7-12,15,17H,5-6,13-14,23H2,1-4H3/t22-/m0/s1
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InChIKey
OWZSSTHDQSTULI-QFIPXVFZSA-N
Physicochemical Property
logP
5.07672
Rotatable Bonds
7
Heavy Atom Count
25
Polar Areas
48.14
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118420369
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02182, AP2-associated protein kinase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000131 HEK293-F Homo sapiens (Human)  1
1
IC50 = 36 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.3 nM