General Information of the Compound
Compound ID
CP0579172
Compound Name
methyl N-[4-[6-[(2S)-2-amino-2,4-dimethylpentoxy]-5-chloropyridin-3-yl]pyridin-2-yl]carbamate
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Structure
Formula
C19H25ClN4O3
Molecular Weight
392.887
Canonical SMILES
COC(=O)Nc1cc(ccn1)-c1cnc(OC[C@@](C)(N)CC(C)C)c(Cl)c1
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InChI
InChI=1S/C19H25ClN4O3/c1-12(2)9-19(3,21)11-27-17-15(20)7-14(10-23-17)13-5-6-22-16(8-13)24-18(25)26-4/h5-8,10,12H,9,11,21H2,1-4H3,(H,22,24,25)/t19-/m0/s1
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InChIKey
PFMMJDPMFCVRCB-IBGZPJMESA-N
Physicochemical Property
logP
4.1176
Rotatable Bonds
7
Heavy Atom Count
27
Polar Areas
99.36
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118429671
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02182, AP2-associated protein kinase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000131 HEK293-F Homo sapiens (Human)  1
1
IC50 = 4.2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.4 nM