General Information of the Protein
Protein ID
PT02075
Protein Name
Alpha-1D adrenergic receptor
Secondarily
Protein Name
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
RA42
Gene Name
ADRA1D
Secondarily
Gene Name
Adra1a
Sequence
MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Adrenergic receptor
Function
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
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Uniprot ID
Primary ID:
P23944

Secondarily ID:
Q71UM4
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Ensembl ID
ENSG00000171873
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0112004
 Compound Info 
1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine
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C19H21ClN2S
  1
1
Ki = 0.15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0040814
 Compound Info 
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
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C19H21N5O4
  1
1
Ki = 0.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0147752
 Compound Info 
1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine
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C19H21ClN2S
  1
1
Ki = 0.47 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0046703
 Compound Info 
1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
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C24H26ClFN4O
  1
1
Ki = 0.66 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0235398
 Compound Info 
(Cyclazosin)[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-octahydro-quinoxalin-1-yl]-furan-2-yl-methanone
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C23H27N5O4
  1
1
Ki = 0.86 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0072419
 Compound Info 
(SNAP-8719)[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-octahydro-quinoxalin-1-yl]-furan-2-yl-methanone
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C22H28F3N3O2
  1
1
Ki = 1.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0228798
 Compound Info 
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C26H29FN8O
  1
1
Ki = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0126862
 Compound Info 
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine
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C24H23FN4
  1
1
Ki = 2.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0267173
 Compound Info 
3-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-oxazolidin-2-one
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C26H28FN7O2
  1
1
Ki = 2.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0333143
 Compound Info 
3-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-1H-quinazoline-2,4-dione
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C32H30FN7O2
  1
1
Ki = 3.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0277576
 Compound Info 
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-pyrazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H31FN6O
  1
1
Ki = 4.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0151333
 Compound Info 
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
  1
1
Ki = 5.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0343878
 Compound Info 
3-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-oxazolidin-2-one
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C27H29FN6O2
  1
1
Ki = 7.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0126860
 Compound Info 
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
  1
1
Ki = 8.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0163622
 Compound Info 
3-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-propionitrile
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C25H25FN6
  1
1
Ki = 9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0320413
 Compound Info 
3-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-1-methyl-pyrrolidin-2-one
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C29H33FN6O
  1
1
Ki = 15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0156782
 Compound Info 
1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(1-methyl-1,2,4-triazol-3-yl)indole
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C23H24FN5
  1
1
Ki = 15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0105167
 Compound Info 
3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indol-3-yl]-piperidin-1-yl}-propionitrile
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C26H24FN5
  1
1
Ki = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0072943
 Compound Info 
3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol;methanesulfonic acid
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C17H19N3O
  1
1
Ki = 45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0134581
 Compound Info 
3-(2-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-oxazolidin-2-one
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C28H28FN5O2
  1
1
Ki = 52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000041 , LTK-
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0049024
 Compound Info 
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine
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C19H25N5O4
  3
1 Kd = 1.479 nM
2 Ki = 3.4 nM
3 Ki = 35 nM
CP0112004
 Compound Info 
1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine
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C19H21ClN2S
  1
1 Ki = 0.076 nM
CP0147752
 Compound Info 
1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine
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C19H21ClN2S
  1
1 Ki = 0.23 nM
CP0040814
 Compound Info 
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
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C19H21N5O4
  2
1 Ki = 0.3 nM
2 Ki = 0.79 nM
CP0046703
 Compound Info 
1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
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C24H26ClFN4O
  1
1 Ki = 0.66 nM
CP0228798
 Compound Info 
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C26H29FN8O
  1
1 Ki = 2 nM
CP0126862
 Compound Info 
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine
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C24H23FN4
  1
1 Ki = 2.5 nM
CP0126860
 Compound Info 
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
  1
1 Ki = 8.6 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01004 Alpha-1D adrenergic receptor Homo sapiens, Human
 Protein Info