General Information of the Protein
Protein ID
PT01962
Protein Name
Protein O-GlcNAcase
Secondarily
Protein Name
Beta-N-acetylglucosaminidase
Beta-N-acetylhexosaminidase
Beta-hexosaminidase
Meningioma-expressed antigen 5
N-acetyl-beta-D-glucosaminidase
N-acetyl-beta-glucosaminidase
Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
Gene Name
OGA
Secondarily
Gene Name
HEXC
KIAA0679
MEA5
MGEA5
Sequence
MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
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Uniprot ID
Primary ID:
O60502

Secondarily ID:
B7WPB9
D3DR79
E9PGF9
O75166
Q86WV0
Q8IV98
Q9BVA5
Q9HAR0
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Ensembl ID
ENSG00000198408
HGNC ID
HGNC:7056
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0444119
4-(4-methylpiperidin-1-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine
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C16H21N5
 1
1
IC50 = 18 nM
   TI
   LI
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CP0444117
4-(4-methylpiperidin-1-yl)-N-(2-phenylethyl)pyrimidin-2-amine
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C18H24N4
 1
1
IC50 = 24 nM
   TI
   LI
   LO
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CP0495620
4-(4-methylpiperidin-1-yl)-N-(2-pyridin-3-ylethyl)pyrimidin-2-amine
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C17H23N5
 1
1
IC50 = 31 nM
   TI
   LI
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CP0549571
N-[1-(4-methylpiperazin-1-yl)propan-2-yl]-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine
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C18H32N6
 1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
CP0573035
N-[5-[[2-(4,6-dimethylpyridin-2-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 1
1
IC50 = 46 nM
   TI
   LI
   LO
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CP0495621
N-[(1-methylimidazol-4-yl)methyl]-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine
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C15H22N6
 1
1
IC50 = 46 nM
   TI
   LI
   LO
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CP0553231
N-[5-[[2-(2-methoxy-6-methylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5O2S
 1
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
CP0225389
N-[5-[[2-(2,5-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 1
1
IC50 = 77.62 nM
   TI
   LI
   LO
   TS
CP0471574
N-[5-[[2-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 2
1
IC50 = 141 nM
   TI
   LI
   LO
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2
IC50 = 141.25 nM
   TI
   LI
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CP0160370
N-[5-[[2-[2-methyl-5-(trifluoromethyl)pyridin-4-yl]-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H24F3N5OS
 1
1
IC50 = 147.91 nM
   TI
   LI
   LO
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CP0519318
N-[5-[[2-(2,6-dimethylpyrimidin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C19H26N6OS
 2
1
IC50 = 169.82 nM
   TI
   LI
   LO
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2
IC50 = 170 nM
   TI
   LI
   LO
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CP0532966
N-[5-[[2-(2,6-dimethylpyridin-4-yl)-6-azaspiro[3.4]octan-6-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H26N4OS
 1
1
IC50 = 182 nM
   TI
   LI
   LO
   TS
CP0330307
N-[5-[[2-(3,5-dimethylpyridin-2-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 1
1
IC50 = 208.93 nM
   TI
   LI
   LO
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CP0533294
N-[5-[[8-(2,6-dimethylpyridin-4-yl)-2-azaspiro[4.4]nonan-2-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C21H28N4OS
 1
1
IC50 = 214 nM
   TI
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CP0575918
CHEMBL4791287
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C21H28N4OS
 1
1
IC50 = 240 nM
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CP0571041
N-[5-[[(5S)-2-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 1
1
IC50 = 281.84 nM
   TI
   LI
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CP0486711
CHEMBL4757711
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C21H28N4OS
 1
1
IC50 = 295 nM
   TI
   LI
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CP0565748
4-(4-methylpiperidin-1-yl)-N-(2-pyridin-2-ylethyl)pyrimidin-2-amine
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C17H23N5
 1
1
IC50 = 360 nM
   TI
   LI
   LO
   TS
CP0471573
N-[5-[[2-[2-methyl-6-(trifluoromethyl)pyridin-4-yl]-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H24F3N5OS
 1
1
IC50 = 380 nM
   TI
   LI
   LO
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CP0557292
5-[1-[7-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-2-yl]ethyl]-2-methyl-1,3-benzothiazole
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C24H30N4S
 1
1
IC50 = 380.19 nM
   TI
   LI
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CP0426275
N-[5-[[2-(5-methylimidazo[1,2-a]pyrimidin-7-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H25N7OS
 1
1
IC50 = 437 nM
   TI
   LI
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CP0533292
N-[5-[[8-[(2,6-dimethylpyridin-4-yl)oxymethyl]-2-azaspiro[4.4]nonan-2-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C22H30N4O2S
 1
1
IC50 = 501 nM
   TI
   LI
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CP0486712
N-[5-[[8-[(2,6-dimethylpyridin-4-yl)methyl]-2-azaspiro[4.4]nonan-2-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C22H30N4OS
 1
1
IC50 = 537 nM
   TI
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CP0533293
N-[5-[[(3S,5S)-3-(2,6-dimethylpyridin-4-yl)oxy-1-oxa-7-azaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H26N4O3S
 1
1
IC50 = 537 nM
   TI
   LI
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CP0572974
N-[5-[[2-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C19H24N8OS
 1
1
IC50 = 575 nM
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CP0573034
N-[5-[[3-(2,6-dimethylpyridin-4-yl)-1-oxa-7-azaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H26N4O2S
 1
1
IC50 = 603 nM
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CP0532282
4-(4-methoxypiperidin-1-yl)-N-(2-phenylethyl)pyrimidin-2-amine
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C18H24N4O
 1
1
IC50 = 970 nM
   TI
   LI
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CP0523224
N-[5-[[2-(6-cyclopropylpyrazin-2-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H26N6OS
 1
1
IC50 = 1000 nM
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CP0560997
4-morpholin-4-yl-N-(2-phenylethyl)pyrimidin-2-amine
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C16H20N4O
 1
1
IC50 = 4700 nM
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CP0532967
N-[5-[[2-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-2,7-diazaspiro[3.4]octan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C18H22N8OS
 1
1
IC50 = 9333 nM
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CP0436019
6-[[(5R)-2-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]quinoxaline
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C23H27N5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
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CP0528317
7-(2,7-diazaspiro[4.4]nonan-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
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C13H18N6
 1
1
IC50 > 10000 nM
   TI
   LI
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CP0535147
N-[5-[[7-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-2,7-diazaspiro[3.4]octan-2-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C18H22N8OS
 1
1
IC50 = 10000 nM
   TI
   LI
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CP0535148
6-[[2-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]quinoxaline
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C22H24N8
 1
1
IC50 > 10000 nM
   TI
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CP0516924
4-(4-methylpiperazin-1-yl)-N-(2-phenylethyl)pyrimidin-2-amine
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C17H23N5
 1
1
IC50 > 10000 nM
   TI
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CP0561816
1-[2-(2-phenylethylamino)pyrimidin-4-yl]piperidin-4-ol
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C17H22N4O
 1
1
IC50 > 10000 nM
   TI
   LI
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CP0571042
2-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonane
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C24H31N3O2
 1
1
IC50 > 1000 nM
   TI
   LI
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CP0533295
7-[7-(1,3-benzodioxol-5-ylmethyl)-2,7-diazaspiro[4.4]nonan-2-yl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
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C21H24N6O2
 1
1
IC50 > 1000 nM
   TI
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CP0553232
2-methyl-5-[[2-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-benzothiazole
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C22H25N7S
 1
1
IC50 > 1000 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0495621
N-[(1-methylimidazol-4-yl)methyl]-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine
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C15H22N6
 2
1 EC50 ~ 450 nM
2 IC50 ~ 46 nM
CP0571041
N-[5-[[(5S)-2-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 1
1 IC50 = 3.715 nM
CP0330307
N-[5-[[2-(3,5-dimethylpyridin-2-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 1
1 IC50 = 3.89 nM
CP0471574
N-[5-[[2-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 1
1 IC50 = 6.026 nM
CP0519318
N-[5-[[2-(2,6-dimethylpyrimidin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C19H26N6OS
 1
1 IC50 = 13.18 nM
CP0225389
N-[5-[[2-(2,5-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H27N5OS
 1
1 IC50 = 13.49 nM
CP0557292
5-[1-[7-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-2-yl]ethyl]-2-methyl-1,3-benzothiazole
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C24H30N4S
 1
1 IC50 = 18.2 nM
CP0523224
N-[5-[[2-(6-cyclopropylpyrazin-2-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H26N6OS
 1
1 IC50 = 20.42 nM
CP0160370
N-[5-[[2-[2-methyl-5-(trifluoromethyl)pyridin-4-yl]-2,7-diazaspiro[4.4]nonan-7-yl]methyl]-1,3-thiazol-2-yl]acetamide
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C20H24F3N5OS
 1
1 IC50 = 36.31 nM
CP0571042
2-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonane
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C24H31N3O2
 1
1 IC50 = 181.97 nM
CP0436019
6-[[(5R)-2-(2,6-dimethylpyridin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]methyl]quinoxaline
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C23H27N5
 1
1 IC50 = 223.87 nM
CP0516924
4-(4-methylpiperazin-1-yl)-N-(2-phenylethyl)pyrimidin-2-amine
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C17H23N5
 1
1 IC50 > 10000 nM
Clinical Information about the Protein
Target 1 ( Beta-N-acetylhexosaminidase (OGA) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Progressive supranuclear palsy [ICD-11: 8A00.10]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 MK-8719 Phase 1
Progressive supranuclear palsy