General Information of the Protein
| Protein ID |
PT01489
|
||||
|---|---|---|---|---|---|
| Protein Name |
3-oxo-5-alpha-steroid 4-dehydrogenase 2
|
||||
| Secondarily Protein Name |
5 alpha-SR2
SR type 2
Steroid 5-alpha-reductase 2
Type II 5-alpha reductase
|
||||
| Gene Name |
SRD5A2
|
||||
| Sequence |
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
Show/Hide
|
||||
| Organism |
Homo sapiens, Human
|
||||
| Protein Classification |
Enzyme
>
Oxidoreductase
|
||||
| Function |
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Show/Hide
|
||||
| Uniprot ID |
Show/Hide
|
||||
| HGNC ID | |||||
| Subcellular Location |
Microsome membrane
Endoplasmic reticulum membrane
|
||||
Map of Molecular Bioactivity Related to the Protein
|
Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
|
|---|
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Cell Line ID: CL001034 , CHO 1829
Cell Line ID: CL000109 , COS-1
Cell Line ID: CL000119 , DU145
Cell Line ID: CL000006 , HEK293
Cell Line ID: CL000420 , SW13
Biochemical Assays
Clinical Information about the Protein