Protein Information

General Information of the Protein

Protein ID	PT01487
Protein Name	Sodium-dependent dopamine transporter
Secondarily Protein Name	Solute carrier family 6 member 3
Gene Name	SLC6A3
Sequence	MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Transporter > Electrochemical transporter > SLC superfamily of solute carriers > SLC06 neurotransmitter transporter family
Function	Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1948035, PubMed:1948034, PubMed:1765147, PubMed:1502198, PubMed:8125921). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:8125921). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Show/Hide
Uniprot ID	P23977
Ensembl ID	ENSG00000142319
Subcellular Location	Cell membrane Cell projection Neuron projection Cell projection Axon

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0526267 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-ylisobutyrate Show/Hide	C19H16O7	1
1	EC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0523789 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-ylpentanoate Show/Hide	C20H18O7	1
1	EC50 = 869 nM Bioactivity Info	TI LI LO TS
CP0496634 Compound Info	2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-ylisobutyrate Show/Hide	C19H16O7	1
1	EC50 = 1375 nM Bioactivity Info	TI LI LO TS
CP0010754 Compound Info	2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one Show/Hide	C15H10O6	1
1	EC50 = 1450 nM Bioactivity Info	TI LI LO TS
CP0521981 Compound Info	2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-ylbutyrate Show/Hide	C19H16O7	1
1	EC50 = 1694 nM Bioactivity Info	TI LI LO TS
CP0406087 Compound Info	2-(3,4-Dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-ylpropionate Show/Hide	C18H14O7	1
1	EC50 = 1696 nM Bioactivity Info	TI LI LO TS
CP0472868 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-ylbutyrate Show/Hide	C19H16O7	1
1	EC50 = 1820 nM Bioactivity Info	TI LI LO TS
CP0506281 Compound Info	2-(3,4-Dihydroxyphenyl)-5-ethoxy-7-hydroxyl-4H-chromen-4-one Show/Hide	C17H14O6	1
1	EC50 = 2213 nM Bioactivity Info	TI LI LO TS
CP0519784 Compound Info	5-butoxy-2-(3,4-dihydroxyphenyl)-7-hydro-xy-4H-chromen-4-one Show/Hide	C19H18O6	1
1	EC50 = 2401.92 nM Bioactivity Info	TI LI LO TS
CP0506287 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-5-(4-ph-enylbutoxy)-4H-chromen-4-one Show/Hide	C25H22O6	1
1	EC50 = 2594 nM Bioactivity Info	TI LI LO TS
CP0385780 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-yl4-methylpentanoate Show/Hide	C21H20O7	1
1	EC50 = 2706 nM Bioactivity Info	TI LI LO TS
CP0523790 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-5-pro-poxy-4H-chromen-4-one Show/Hide	C18H16O6	1
1	EC50 = 3072 nM Bioactivity Info	TI LI LO TS
CP0526268 Compound Info	2-(3,4-Dihydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one Show/Hide	C17H14O6	1
1	EC50 = 3417 nM Bioactivity Info	TI LI LO TS
CP0496633 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-5-(iso-pentyloxy)-4H-chromen-4-one Show/Hide	C20H20O6	1
1	EC50 = 3428 nM Bioactivity Info	TI LI LO TS
CP0506258 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-5-meth-oxy-4H-chromen-4-one Show/Hide	C16H12O6	1
1	EC50 = 4345 nM Bioactivity Info	TI LI LO TS
CP0521980 Compound Info	2-(3,4-dihydroxyphenyl)-5-(hexyloxy)-7-hy-droxy-4H-chromen-4-one Show/Hide	C21H22O6	1
1	EC50 = 4575 nM Bioactivity Info	TI LI LO TS
CP0506282 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-5-isobu-toxy-4H-chromen-4-one Show/Hide	C19H18O6	1
1	EC50 = 4798 nM Bioactivity Info	TI LI LO TS
CP0385778 Compound Info	2-(3,4-Dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-ylacetate Show/Hide	C17H12O7	1
1	EC50 = 5368 nM Bioactivity Info	TI LI LO TS
CP0523791 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-5-iso-propoxy-4H-chromen-4-one Show/Hide	C18H16O6	1
1	EC50 = 5430 nM Bioactivity Info	TI LI LO TS
CP0519782 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-yl4-methylben-zoate Show/Hide	C23H16O7	1
1	EC50 = 6920 nM Bioactivity Info	TI LI LO TS
CP0506280 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-yloctanoate Show/Hide	C23H24O7	1
1	EC50 = 8557 nM Bioactivity Info	TI LI LO TS
CP0496632 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-ylbenzoate Show/Hide	C22H14O7	1
1	EC50 = 11174 nM Bioactivity Info	TI LI LO TS
CP0519785 Compound Info	2-(3-ethoxy-4-hydroxyphenyl)-5,7-dihydro-xy-4H-chromen-4-one Show/Hide	C17H14O6	1
1	EC50 = 12856 nM Bioactivity Info	TI LI LO TS
CP0524079 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-5-(octy-loxy)-4H-chromen-4-one Show/Hide	C23H26O6	1
1	EC50 = 16521 nM Bioactivity Info	TI LI LO TS
CP0511834 Compound Info	2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-ylpropionate Show/Hide	C18H14O7	1
1	EC50 = 30978 nM Bioactivity Info	TI LI LO TS
CP0385781 Compound Info	5-(decyloxy)-2-(3,4-dihydroxyphenyl)-7-hy-droxy-4H-chromen-4-one Show/Hide	C25H30O6	1
1	EC50 = 33002 nM Bioactivity Info	TI LI LO TS
CP0035807 Compound Info	Cocaine Show/Hide	C17H21NO4	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0449426 Compound Info	(2S)-2-amino-3-[4-[4-[(3S)-3-amino-4-[[(2S)-1-[[(2S,3R)-1-[(2S)-2-[[(2S,3R)-1-(carboxymethylamino)-1-oxo-3-phenylmethoxybutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutan-2-yl]phenyl]phenyl]propanoic acid Show/Hide	C50H61N7O12	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0933737 Compound Info	bip-tyr-thr-ala-pro-phe Show/Hide	C45H52N6O10	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0941737 Compound Info	bip-tyr-thr-pro-ala-thr(obzl)-gly Show/Hide	C52H64N8O13	1
1	IC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0453014 Compound Info	(2S)-2-amino-3-[4-[4-[(2S)-2-amino-3-[[(2S)-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-6-amino-1-[[(2S,3R)-1-(carboxymethylamino)-1-oxo-3-phenylmethoxybutan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]phenyl]propanoic acid Show/Hide	C55H71N9O13	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0453016 Compound Info	(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-amino-3-[4-[4-[(2S)-2-amino-2-carboxyethyl]phenyl]phenyl]propanoyl]amino]-3-(3-benzyl-4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-hydroxybutanoic acid Show/Hide	C53H68N8O12	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0453017 Compound Info	(2S)-2-amino-3-[4-[4-[(2S)-2-amino-3-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-1-[[(2S,3R)-1-(carboxymethylamino)-1-oxo-3-phenylmethoxybutan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]phenyl]propanoic acid Show/Hide	C54H69N9O12	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0451862 Compound Info	(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-amino-3-[4-[4-[(2S)-2-amino-2-carboxyethyl]phenyl]phenyl]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-hydroxybutanoic acid Show/Hide	C46H62N8O12	1
1	IC50 = 19000 nM Bioactivity Info	TI LI LO TS
CP0453015 Compound Info	(2S)-2-amino-3-[4-[4-[(2S)-2-amino-3-[[(2S)-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-6-amino-1-[[(2S,3R)-1-(carboxymethylamino)-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylmethoxybutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]phenyl]propanoic acid Show/Hide	C55H71N9O13	1
1	IC50 = 20000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000335 , D8

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000009 , LLC-PK1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0035807 Compound Info	Cocaine Show/Hide	C17H21NO4	26
1	IC50 = 66 nM
2	IC50 = 67.8 nM
3	IC50 = 89 nM
4	IC50 = 89.1 nM
5	IC50 = 102 nM
6	IC50 = 139 nM
7	IC50 = 150 nM
8	IC50 = 160 nM
9	IC50 = 205 nM
10	IC50 = 249 nM
11	IC50 = 341 nM
12	IC50 = 404 nM
13	IC50 = 478 nM
14	IC50 = 660 nM
15	IC50 = 843 nM
16	IC50 = 1450 nM
17	IC50 = 1810 nM
18	Ki = 187 nM
19	Ki = 230 nM
20	Ki = 241.3 nM
21	Ki = 274 nM
22	Ki = 285 nM
23	Ki = 388 nM
24	Ki = 420 nM
25	Ki = 423 nM
26	Ki = 32000 nM

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT00884	Sodium-dependent dopamine transporter	Homo sapiens, Human	Protein Info
PT03401	Sodium-dependent dopamine transporter	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han