General Information of the Protein
Protein ID
PT03401
Protein Name
Sodium-dependent dopamine transporter
Secondarily
Protein Name
Solute carrier family 6 member 3
Gene Name
SLC6A3
Secondarily
Gene Name
Dat
Dat1
Sequence
MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDRQLVDRGEVRQFTLRHWLLV
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Organism
Mus musculus, Mouse
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:12606774). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (PubMed:30936473).
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Uniprot ID
Primary ID:
Q61327

Secondarily ID:
Q60719
Q9R1I2
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Ensembl ID
ENSG00000142319
Subcellular Location
Cell membrane
Cell projection
Neuron projection
Cell projection
Axon
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0393494
 Compound Info 
methyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate
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C20H18ClN5O4S
  2
1
EC50 = 810 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 940 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405283
 Compound Info 
ethyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate
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C21H20ClN5O4S
  2
1
EC50 = 1070 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0393811
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(5-bromothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H19BrN6O3S
  2
1
EC50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 3260 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0089367
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H19ClN6O3S
  2
1
EC50 = 2230 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 2290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0393806
 Compound Info 
(1S,2R,3S,4R,5S)-4-[6-[2-(5-chlorothiophen-2-yl)ethynyl]-4-(methylamino)imidazo[4,5-c]pyridin-1-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C21H20ClN5O3S
  2
1
EC50 = 2760 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 4300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0062351
 Compound Info 
42-548
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C16H13ClN2O
  2
1
IC50 = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 404 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035807
 Compound Info 
Cocaine
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C17H21NO4
  2
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 850 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT00884 Sodium-dependent dopamine transporter Homo sapiens, Human
 Protein Info 
PT01487 Sodium-dependent dopamine transporter Rattus norvegicus, Rat
 Protein Info