Protein Information

General Information of the Protein

Protein ID	PT01473
Protein Name	Glucagon receptor
Gene Name	GCGR
Sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family B G protein-coupled receptor > Peptide receptor (family B GPCR) > Glucagon-like receptor > Glucagon receptor
Function	G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. Show/Hide
Uniprot ID	Primary ID: P47871 Secondarily ID: Q2M3M5 Show/Hide
HGNC ID	HGNC:4192
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000051 , BHK-21

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0134277 Compound Info	3-Cyano-4-hydroxy-benzoic acid [1-(2,3,5,6-tetramethyl-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C28H26N4O2	1
1	IC50 = 2.3 nM Bioactivity Info	TI LI LO TS
CP0910043 Compound Info	Cyclopentanecarboxylic acid {4-[(3-cyano-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalen-1-yl}-cyclopentanecarbonyl-amide Show/Hide	C31H30N4O4	1
1	IC50 = 2.8 nM Bioactivity Info	TI LI LO TS
CP0869586 Compound Info	Cyclopentanecarboxylic acid {4-[(3-chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalen-1-yl}-cyclopentanecarbonyl-amide Show/Hide	C30H30ClN3O4	1
1	IC50 = 3.4 nM Bioactivity Info	TI LI LO TS
CP0070503 Compound Info	(R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H29Cl2N3O5	1
1	IC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0441152 Compound Info	(R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H31Cl2N3O5	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0358493 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-benzyloxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazide Show/Hide	C28H25ClN2O3	1
1	IC50 = 4.3 nM Bioactivity Info	TI LI LO TS
CP0467464 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-oxo-ethyl}-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C31H28Cl2N4O3	1
1	IC50 = 4.6 nM Bioactivity Info	TI LI LO TS
CP0492454 Compound Info	3-Cyano-4-hydroxy-benzoic acid {4-[4-(4-chloro-benzyl)-piperazine-1-carbonyl]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C31H26ClN5O3	1
1	IC50 = 4.9 nM Bioactivity Info	TI LI LO TS
CP0462586 Compound Info	(R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methanesulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C32H32F3N3O8S	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0504622 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(2,3,5,6-tetramethyl-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C27H26ClN3O2	1
1	IC50 = 5.3 nM Bioactivity Info	TI LI LO TS
CP0497587 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(2,4,6-trimethyl-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C26H24ClN3O2	1
1	IC50 = 5.8 nM Bioactivity Info	TI LI LO TS
CP0437619 Compound Info	4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalene-1-carboxylic acid [2-(4-chloro-phenyl)-ethyl]-amide Show/Hide	C27H21Cl2N3O3	1
1	IC50 = 5.9 nM Bioactivity Info	TI LI LO TS
CP0463788 Compound Info	(R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromethylsulfanylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C31H32F3N3O5S	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0503148 Compound Info	(R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluoro-4H-benzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C32H29F4N3O7	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0464831 Compound Info	3-Cyano-4-hydroxy-benzoic acid (4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C32H25BrN4O4	1
1	IC50 = 6.1 nM Bioactivity Info	TI LI LO TS
CP0527656 Compound Info	N-[(E)-[4-[2-[benzyl-[2-(dimethylamino)ethyl]amino]-2-oxoethyl]naphthalen-1-yl]methylideneamino]-3-chloro-4-hydroxybenzamide Show/Hide	C31H31ClN4O3	1
1	IC50 = 6.2 nM Bioactivity Info	TI LI LO TS
CP0462323 Compound Info	3-cyano-N-[(E)-[1-(2-cyclopentylacetyl)indol-3-yl]methylideneamino]-4-hydroxybenzamide Show/Hide	C24H22N4O3	1
1	IC50 = 6.4 nM Bioactivity Info	TI LI LO TS
CP0508894 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C31H25BrClN3O4	1
1	IC50 = 6.6 nM Bioactivity Info	TI LI LO TS
CP0515732 Compound Info	3-chloro-4-hydroxy-N-[(E)-[4-[[4-(trifluoromethoxy)phenyl]methylsulfonylmethyl]naphthalen-1-yl]methylideneamino]benzamide Show/Hide	C27H20ClF3N2O5S	1
1	IC50 = 6.9 nM Bioactivity Info	TI LI LO TS
CP0459788 Compound Info	(R)-3-{4-[3-(3-Bromo-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C31H29BrF3N3O5	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0391322 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(2-ethyl-piperidin-1-yl)-2-oxo-ethyl]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C27H28ClN3O3	1
1	IC50 = 7.4 nM Bioactivity Info	TI LI LO TS
CP0497915 Compound Info	N-[(E)-[4-[[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]naphthalen-1-yl]methylideneamino]-3-chloro-4-hydroxybenzamide Show/Hide	C27H23ClN4O3	1
1	IC50 = 7.4 nM Bioactivity Info	TI LI LO TS
CP0436745 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C30H26ClFN4O3	1
1	IC50 = 7.9 nM Bioactivity Info	TI LI LO TS
CP0383869 Compound Info	(R)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-tert-butylcyclohexyl)ureidomethyl]-benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H35F6N3O5	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0459789 Compound Info	(R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H32BrN3O5	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0431401 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(2-methyl-piperidin-1-yl)-2-oxo-ethyl]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C26H26ClN3O3	1
1	IC50 = 8.3 nM Bioactivity Info	TI LI LO TS
CP0527654 Compound Info	3-Chloro-4-hydroxy-benzoic acid [4-(4-chloro-benzylamino)-naphthalen-1-ylmethylene]-hydrazide Show/Hide	C25H19Cl2N3O2	1
1	IC50 = 8.3 nM Bioactivity Info	TI LI LO TS
CP0435018 Compound Info	(R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methylthio)phenyl-ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C31H35N3O5S	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0497971 Compound Info	(R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methoxy-5-trifluoromethylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionicacid Show/Hide	C32H34F3N3O6	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0517419 Compound Info	(R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C32H31F3N4O5	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0432380 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(4-benzyl-piperazin-1-yl)-2-oxo-ethyl]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C31H29ClN4O3	1
1	IC50 = 9.2 nM Bioactivity Info	TI LI LO TS
CP0423784 Compound Info	(R)-trans-3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(3-methyl-5-trifluoromethylphenyl)ureidomethyl]benzoylamino}-2-hydroxy-propionic acid Show/Hide	C30H38F3N3O5	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0474597 Compound Info	N-[(E)-[4-[2-[benzyl-[2-(dimethylamino)ethyl]amino]-2-oxoethyl]naphthalen-1-yl]methylideneamino]-3-cyano-4-hydroxybenzamide Show/Hide	C32H31N5O3	1
1	IC50 = 10.4 nM Bioactivity Info	TI LI LO TS
CP0508907 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[4-(4-chloro-benzyl)-piperazine-1-carbonyl]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C30H26Cl2N4O3	1
1	IC50 = 11.3 nM Bioactivity Info	TI LI LO TS
CP0492544 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-bromo-phenyl)-4-hydroxy-piperidin-1-yl]-2-oxo-ethoxy}-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C31H27BrClN3O5	1
1	IC50 = 11.4 nM Bioactivity Info	TI LI LO TS
CP0404471 Compound Info	3-Cyano-4-hydroxy-benzoic acid {4-[2-(2-methyl-piperidin-1-yl)-2-oxo-ethyl]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C27H26N4O3	1
1	IC50 = 11.6 nM Bioactivity Info	TI LI LO TS
CP0211346 Compound Info	3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C30H29Cl2N3O4	2
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
2	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0565416 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C30H26ClFN4O3	1
1	IC50 = 12.3 nM Bioactivity Info	TI LI LO TS
CP0430977 Compound Info	3-chloro-4-hydroxy-N-[(E)-[5-[[4-(trifluoromethoxy)phenyl]methoxy]naphthalen-1-yl]methylideneamino]benzamide Show/Hide	C26H18ClF3N2O4	1
1	IC50 = 12.9 nM Bioactivity Info	TI LI LO TS
CP0375059 Compound Info	(R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-fluoro-5-trifluoromethylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C31H29F4N3O5	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0497916 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethoxy]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C29H24ClN3O4	1
1	IC50 = 13.8 nM Bioactivity Info	TI LI LO TS
CP0375060 Compound Info	(R)-3-{4-[3-(3-Chlorophenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H30ClN3O5	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0423783 Compound Info	(R/S)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H29Cl2N3O5	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0454980 Compound Info	(R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methoxy-5-trifluoromethylphenyl)ureidomethyl]-benzoylamino}-2-hydroxypropionic acid Show/Hide	C32H32F3N3O6	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0503427 Compound Info	3-chloro-4-hydroxy-N-[(E)-[2-methoxy-4-[[2-[4-(trifluoromethoxy)phenyl]sulfanylacetyl]amino]phenyl]methylideneamino]benzamide Show/Hide	C24H19ClF3N3O5S	1
1	IC50 = 14.5 nM Bioactivity Info	TI LI LO TS
CP0494732 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(3,4-dichloro-benzylamino)-ethoxy]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C27H22Cl3N3O3	1
1	IC50 = 14.7 nM Bioactivity Info	TI LI LO TS
CP0492455 Compound Info	3-cyano-4-hydroxy-N-[(E)-[2-methoxy-4-[3-[4-(trifluoromethyl)phenyl]propanoylamino]phenyl]methylideneamino]benzamide Show/Hide	C26H21F3N4O4	1
1	IC50 = 15.7 nM Bioactivity Info	TI LI LO TS
CP0430821 Compound Info	3-[[4-[[[3,5-bis(trifluoromethyl)phenyl]carbamoyl-(4-tert-butylcyclohexyl)amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C30H35F6N3O4	2
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
2	IC50 = 56 nM Bioactivity Info	TI LI LO TS
CP0516016 Compound Info	2-{4-[(3-Cyano-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalen-1-yl}-N,N-diethyl-acetamide Show/Hide	C25H24N4O3	1
1	IC50 = 16.5 nM Bioactivity Info	TI LI LO TS
CP0459787 Compound Info	(R)-3-{4-[3-(3-tert-Butylphenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C34H41N3O5	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0431442 Compound Info	3-cyano-N-[(E)-[1-[4-(dimethylamino)benzoyl]indol-3-yl]methylideneamino]-4-hydroxybenzamide Show/Hide	C26H21N5O3	1
1	IC50 = 19.1 nM Bioactivity Info	TI LI LO TS
CP0500229 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-{2-[2-(4-bromo-phenyl)-ethylamino]-ethoxy}-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C28H25BrClN3O3	1
1	IC50 = 19.7 nM Bioactivity Info	TI LI LO TS
CP0045459 Compound Info	3-Cyano-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-benzyloxy)-3,5-dimethoxy-phenyl]-meth-(E)-ylidene]-hydrazide Show/Hide	C27H27N3O5	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0919228 Compound Info	N-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-3-methoxy-phenyl}-3-(4-trifluoromethyl-phenyl)-propionamide Show/Hide	C25H23ClF3N3O5	1
1	IC50 = 21.2 nM Bioactivity Info	TI LI LO TS
CP0408083 Compound Info	3-Cyano-4-hydroxy-benzoic acid [1-(4-trifluoromethyl-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C25H17F3N4O2	1
1	IC50 = 22.3 nM Bioactivity Info	TI LI LO TS
CP0430978 Compound Info	2-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalen-1-yl}-N,N-diethyl-acetamide Show/Hide	C24H24ClN3O3	1
1	IC50 = 22.6 nM Bioactivity Info	TI LI LO TS
CP0492624 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(4-trifluoromethoxy-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C24H17ClF3N3O3	1
1	IC50 = 22.9 nM Bioactivity Info	TI LI LO TS
CP0269118 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(4-isopropyl-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C26H24ClN3O2	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0435017 Compound Info	3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C29H36F3N3O5	1
1	IC50 = 23.4 nM Bioactivity Info	TI LI LO TS
CP0475022 Compound Info	thiazole, 28 Show/Hide	C28H22ClF3N2O4S	2
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
2	IC50 = 153 nM Bioactivity Info	TI LI LO TS
CP0387508 Compound Info	(R)-trans-3-{4-[1-(4-tert-Butylcyclohexyl)-3-(3,5-dimethylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H41N3O5	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0463735 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(3,4-dichloro-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C23H16Cl3N3O2	1
1	IC50 = 27.5 nM Bioactivity Info	TI LI LO TS
CP0471839 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(4-trifluoromethoxy-benzylamino)-ethoxy]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C28H23ClF3N3O4	1
1	IC50 = 27.7 nM Bioactivity Info	TI LI LO TS
CP0492322 Compound Info	2-(4-Chloro-phenyl)-N-{4-[(3-cyano-4-hydroxy-benzoyl)-hydrazonomethyl]-3-methoxy-phenyl}-acetamide Show/Hide	C24H19ClN4O4	1
1	IC50 = 28.7 nM Bioactivity Info	TI LI LO TS
CP0492305 Compound Info	3-Fluoro-4-hydroxy-benzoic acid (4-hydroxymethyl-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C19H15FN2O3	1
1	IC50 = 29.4 nM Bioactivity Info	TI LI LO TS
CP0492289 Compound Info	3-Cyano-4-hydroxy-benzoic acid (4-hydroxymethyl-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C20H15N3O3	1
1	IC50 = 29.8 nM Bioactivity Info	TI LI LO TS
CP0502489 Compound Info	3-chloro-N-[(E)-[4-(2,2-dimethylpropanoylamino)naphthalen-1-yl]methylideneamino]-4-hydroxybenzamide Show/Hide	C23H22ClN3O3	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0432456 Compound Info	3-chloro-4-hydroxy-N-[(E)-[2-methoxy-4-[3-[4-(trifluoromethyl)phenyl]propanoylamino]phenyl]methylideneamino]benzamide Show/Hide	C25H21ClF3N3O4	1
1	IC50 = 33.5 nM Bioactivity Info	TI LI LO TS
CP0483803 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(4-trifluoromethyl-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C24H17ClF3N3O2	1
1	IC50 = 33.8 nM Bioactivity Info	TI LI LO TS
CP0374454 Compound Info	aminothiazole, 21 Show/Hide	C28H21F6N3O3S2	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0374455 Compound Info	aminothiazole, 24 Show/Hide	C33H26ClN3O3S	2
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
2	IC50 = 93 nM Bioactivity Info	TI LI LO TS
CP0502729 Compound Info	3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-isopropylphenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C31H43N3O4	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0497661 Compound Info	4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalene-1-carboxylic acid diethylamide Show/Hide	C23H22ClN3O3	1
1	IC50 = 35.4 nM Bioactivity Info	TI LI LO TS
CP0443414 Compound Info	aminothiazole, 3 Show/Hide	C33H30F3N3O4S	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0500823 Compound Info	3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionicacid Show/Hide	C29H30F3N3O5	2
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
2	IC50 = 96 nM Bioactivity Info	TI LI LO TS
CP0374456 Compound Info	thiazole, 27 Show/Hide	C28H22ClF3N2O3S	2
1	IC50 = 38 nM Bioactivity Info	TI LI LO TS
2	IC50 = 96 nM Bioactivity Info	TI LI LO TS
CP0492319 Compound Info	3-chloro-N-[(E)-[4-(cyclopentanecarbonylamino)naphthalen-1-yl]methylideneamino]-4-hydroxybenzamide Show/Hide	C24H22ClN3O3	1
1	IC50 = 38.8 nM Bioactivity Info	TI LI LO TS
CP0535009 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-hydroxymethyl-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C19H15ClN2O3	1
1	IC50 = 41.1 nM Bioactivity Info	TI LI LO TS
CP0538146 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C29H36F3N3O5	1
1	IC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0522589 Compound Info	3-cyano-4-hydroxy-N-[(E)-[2-methoxy-4-[[2-[3-(trifluoromethyl)phenyl]acetyl]amino]phenyl]methylideneamino]benzamide Show/Hide	C25H19F3N4O4	1
1	IC50 = 47.8 nM Bioactivity Info	TI LI LO TS
CP0475018 Compound Info	aminothiazole, 4 Show/Hide	C33H30F3N3O3S	1
1	IC50 = 48 nM Bioactivity Info	TI LI LO TS
CP0443415 Compound Info	aminothiazole, 11 Show/Hide	C31H28F3N3O3S	2
1	IC50 = 48 nM Bioactivity Info	TI LI LO TS
2	IC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0362260 Compound Info	2-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalen-1-yloxy}-N,N-diethyl-acetamide Show/Hide	C24H24ClN3O4	1
1	IC50 = 49.7 nM Bioactivity Info	TI LI LO TS
CP0443411 Compound Info	aminothiazole, 6 Show/Hide	C34H26F3N3O4S	2
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
2	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0468561 Compound Info	aminothiazole, 19 Show/Hide	C28H21F6N3O4S	2
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
2	IC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0466540 Compound Info	(S)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H29Cl2N3O5	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0492190 Compound Info	2-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalen-1-yloxy}-N-(4-chloro-phenyl)-acetamide Show/Hide	C26H19Cl2N3O4	1
1	IC50 = 51.7 nM Bioactivity Info	TI LI LO TS
CP0443416 Compound Info	aminothiazole, 17 Show/Hide	C27H21ClF3N3O4S	2
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
2	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0475021 Compound Info	aminothiazole, 16 Show/Hide	C27H21ClF3N3O3S	2
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
2	IC50 = 76 nM Bioactivity Info	TI LI LO TS
CP0492316 Compound Info	2,3-Dichloro-4-hydroxy-benzoic acid (4-hydroxymethyl-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C19H14Cl2N2O3	1
1	IC50 = 53.8 nM Bioactivity Info	TI LI LO TS
CP0374482 Compound Info	aminothiazole, 10 Show/Hide	C30H27Cl2N3O3S	2
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
2	IC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0514590 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(2-trifluoromethoxy-benzylamino)-ethoxy]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C28H23ClF3N3O4	1
1	IC50 = 54.3 nM Bioactivity Info	TI LI LO TS
CP0047783 Compound Info	3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluoromethoxy-phenyl)-ureidomethyl]-benzoylamino}-propionic acid Show/Hide	C29H36F3N3O5	1
1	IC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0462530 Compound Info	(R/S)-3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C29H30F3N3O6	1
1	IC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0553738 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[[2-cyano-4-(trifluoromethoxy)phenyl]carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C30H35F3N4O5	1
1	IC50 = 56 nM Bioactivity Info	TI LI LO TS
CP0538145 Compound Info	3-(4-((1-(4-isopropylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C28H34F3N3O5	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0526964 Compound Info	3-(4-((1-(4-cyclohexylphenyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C31H32F3N3O5	1
1	IC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0480507 Compound Info	N-[(E)-[4-[[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]methyl]naphthalen-1-yl]methylideneamino]-3-chloro-4-hydroxybenzamide Show/Hide	C28H25ClN4O3	1
1	IC50 = 61.8 nM Bioactivity Info	TI LI LO TS
CP0462325 Compound Info	2-Benzo[b]thiophen-3-yl-N-{4-[(3-chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-2-methoxy-phenyl}-acetamide Show/Hide	C25H20ClN3O4S	1
1	IC50 = 63.2 nM Bioactivity Info	TI LI LO TS
CP0494615 Compound Info	aminothiazole, 7 Show/Hide	C30H26F3N3O3S	2
1	IC50 = 64 nM Bioactivity Info	TI LI LO TS
2	IC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0437677 Compound Info	3-chloro-4-hydroxy-N-[(E)-[3-methoxy-4-[[2-[4-(trifluoromethoxy)phenoxy]acetyl]amino]phenyl]methylideneamino]benzamide Show/Hide	C24H19ClF3N3O6	1
1	IC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0497648 Compound Info	3-chloro-4-hydroxy-N-[(E)-[4-(methoxymethyl)naphthalen-1-yl]methylideneamino]benzamide Show/Hide	C20H17ClN2O3	1
1	IC50 = 75.5 nM Bioactivity Info	TI LI LO TS
CP0495975 Compound Info	aminothiazole, 25 Show/Hide	C34H26F3N3O3S	1
1	IC50 = 78 nM Bioactivity Info	TI LI LO TS
CP0495984 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[(3,5-dichlorophenyl)carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C28H35Cl2N3O4	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0445398 Compound Info	aminothiazole, 26 Show/Hide	C34H26F3N3O4S	1
1	IC50 = 81 nM Bioactivity Info	TI LI LO TS
CP0497970 Compound Info	(S)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-tert-butylcyclohexyl)ureidomethyl]-benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H35F6N3O5	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0443417 Compound Info	aminothiazole, 8 Show/Hide	C30H26F3N3O4S	2
1	IC50 = 85 nM Bioactivity Info	TI LI LO TS
2	IC50 = 96 nM Bioactivity Info	TI LI LO TS
CP0374468 Compound Info	aminothiazole, 5 Show/Hide	C38H34ClN3O3S	1
1	IC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0404531 Compound Info	N-[(E)-[4-[2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethoxy]naphthalen-1-yl]methylideneamino]-3-chloro-4-hydroxybenzamide Show/Hide	C31H29ClN4O4	1
1	IC50 = 89.3 nM Bioactivity Info	TI LI LO TS
CP0383071 Compound Info	5-Methoxy-benzofuran-2-carboxylic acid {4-[(3-chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-3-methoxy-phenyl}-amide Show/Hide	C25H20ClN3O6	1
1	IC50 = 90.6 nM Bioactivity Info	TI LI LO TS
CP0468560 Compound Info	aminothiazole, 18 Show/Hide	C27H21ClF3N3O3S	2
1	IC50 = 92 nM Bioactivity Info	TI LI LO TS
2	IC50 = 93 nM Bioactivity Info	TI LI LO TS
CP0443412 Compound Info	aminothiazole, 12 Show/Hide	C31H30F3N3O3S	2
1	IC50 = 93 nM Bioactivity Info	TI LI LO TS
2	IC50 = 119 nM Bioactivity Info	TI LI LO TS
CP0434378 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C30H28Cl2N4O2	1
1	IC50 = 96.7 nM Bioactivity Info	TI LI LO TS
CP0494614 Compound Info	thiazole, 29 Show/Hide	C28H22ClF3N2O4S	1
1	IC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0485224 Compound Info	aminothiazole, 9 Show/Hide	C29H25Cl2N3O3S	1
1	IC50 = 99 nM Bioactivity Info	TI LI LO TS
CP0377320 Compound Info	3-(4-{[N-(5-chlorobenzo[b]thiophen-3-carbonyl)-N-(2,2-diphenylethyl)amino]methyl}benzoylamino)propionic acid Show/Hide	C33H27ClN2O4S	1
1	IC50 = 116 nM Bioactivity Info	TI LI LO TS
CP0485223 Compound Info	aminothiazole, 2 Show/Hide	C36H39N3O3S	1
1	IC50 = 118 nM Bioactivity Info	TI LI LO TS
CP0495973 Compound Info	thiazole, 30 Show/Hide	C29H22F6N2O5S	1
1	IC50 = 119 nM Bioactivity Info	TI LI LO TS
CP0392904 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-ethoxy]-2-methoxy-benzylidene}-hydrazide Show/Hide	C26H26ClN3O4	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0523167 Compound Info	3-{4-[1-(4-propylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid Show/Hide	C28H34F3N3O5	1
1	IC50 = 122 nM Bioactivity Info	TI LI LO TS
CP0435234 Compound Info	aminothiazole, 1 Show/Hide	C32H31N3O3S	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0374471 Compound Info	aminothiazole, 13 Show/Hide	C32H29F6N3O3S	1
1	IC50 = 131 nM Bioactivity Info	TI LI LO TS
CP0467361 Compound Info	3-Chloro-4-hydroxy-benzoic acid {2-methoxy-4-[2-(4-trifluoromethyl-benzylamino)-ethoxy]-benzylidene}-hydrazide Show/Hide	C25H23ClF3N3O4	1
1	IC50 = 133 nM Bioactivity Info	TI LI LO TS
CP0386530 Compound Info	3-(4-((1-(4,4-dipropylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C31H40F3N3O5	1
1	IC50 = 137 nM Bioactivity Info	TI LI LO TS
CP0528569 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[[4-(cyclopropylmethoxy)phenyl]carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C32H43N3O5	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0428129 Compound Info	3-(4-((1-(heptan-3-yl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C26H32F3N3O5	1
1	IC50 = 141 nM Bioactivity Info	TI LI LO TS
CP0377323 Compound Info	3-[[4-[[[2-bromo-4-(trifluoromethoxy)phenyl]carbamoyl-(4-tert-butylcyclohexyl)amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C29H35BrF3N3O5	1
1	IC50 = 153 nM Bioactivity Info	TI LI LO TS
CP0461108 Compound Info	3-cyano-4-hydroxy-N-[(E)-[4-(propan-2-ylsulfonylmethyl)naphthalen-1-yl]methylideneamino]benzamide Show/Hide	C23H21N3O4S	1
1	IC50 = 163 nM Bioactivity Info	TI LI LO TS
CP0375061 Compound Info	(R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-phenyl-ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H31N3O5	1
1	IC50 = 166 nM Bioactivity Info	TI LI LO TS
CP0495983 Compound Info	3-(4-((1-(4-cyclohexylphenyl)-3-(3-nitrophenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C30H32N4O6	1
1	IC50 = 167 nM Bioactivity Info	TI LI LO TS
CP0537914 Compound Info	3-(4-((3-(4-butylphenyl)-1-(2,3-dihydro-1H-inden-2-yl)ureido)methyl)benzamido)propanoic acid Show/Hide	C31H35N3O4	1
1	IC50 = 179 nM Bioactivity Info	TI LI LO TS
CP0457258 Compound Info	3-Chloro-4-hydroxy-benzoic acid [4-(2-methyl-propane-1-sulfonyl)-naphthalen-1-ylmethylene]-hydrazide Show/Hide	C22H21ClN2O4S	1
1	IC50 = 181 nM Bioactivity Info	TI LI LO TS
CP0553739 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[[4-(cyclopropylmethoxy)-2-(trifluoromethyl)phenyl]carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C33H42F3N3O5	1
1	IC50 = 182 nM Bioactivity Info	TI LI LO TS
CP0448297 Compound Info	3-Chloro-4-hydroxy-benzoic acid (5-hydroxymethyl-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C19H15ClN2O3	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0129520 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-hydroxy-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C18H13ClN2O3	1
1	IC50 = 203 nM Bioactivity Info	TI LI LO TS
CP0419621 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[[4-cyano-2-(trifluoromethoxy)phenyl]carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C30H35F3N4O5	1
1	IC50 = 215 nM Bioactivity Info	TI LI LO TS
CP0462046 Compound Info	3-chloro-N-[(E)-[4-(cyclopentylsulfonylmethyl)naphthalen-1-yl]methylideneamino]-4-hydroxybenzamide Show/Hide	C24H23ClN2O4S	1
1	IC50 = 221 nM Bioactivity Info	TI LI LO TS
CP0495972 Compound Info	aminothiazole, 22 Show/Hide	C30H26F3N3O5S	1
1	IC50 = 225 nM Bioactivity Info	TI LI LO TS
CP0518067 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[(3,4-dichlorophenyl)carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C28H35Cl2N3O4	1
1	IC50 = 226 nM Bioactivity Info	TI LI LO TS
CP0485225 Compound Info	aminothiazole, 23 Show/Hide	C30H26F3N3O4S	1
1	IC50 = 261 nM Bioactivity Info	TI LI LO TS
CP0529681 Compound Info	3-(4-((1-(2,3-dihydro-1H-inden-2-yl)-3-(4-(trifluoromethylthio)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C28H26F3N3O4S	1
1	IC50 = 262 nM Bioactivity Info	TI LI LO TS
CP0414828 Compound Info	3-Chloro-4-hydroxy-benzoic acid {4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-naphthalen-1-ylmethylene}-hydrazide Show/Hide	C25H25ClN4O3	1
1	IC50 = 268 nM Bioactivity Info	TI LI LO TS
CP0425328 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(4-trifluoromethoxy-benzyl)-1H-indol-5-ylmethylene]-hydrazide Show/Hide	C24H17ClF3N3O3	1
1	IC50 = 286 nM Bioactivity Info	TI LI LO TS
CP0466338 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(4-difluoromethoxy-benzyl)-1H-indol-3-ylmethylene]-hydrazide Show/Hide	C24H18ClF2N3O3	1
1	IC50 = 305 nM Bioactivity Info	TI LI LO TS
CP0547270 Compound Info	aminothiazole, 14 Show/Hide	C34H39N3O3S	1
1	IC50 = 315 nM Bioactivity Info	TI LI LO TS
CP0463061 Compound Info	3-Chloro-4-hydroxy-benzoic acid [4-(propane-2-sulfonyl)-naphthalen-1-ylmethylene]-hydrazide Show/Hide	C21H19ClN2O4S	1
1	IC50 = 357 nM Bioactivity Info	TI LI LO TS
CP0443413 Compound Info	aminothiazole, 20 Show/Hide	C28H24F3N3O4S2	1
1	IC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0559933 Compound Info	2-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalen-1-yl}-N-(2-dimethylamino-ethyl)-N-methyl-acetamide Show/Hide	C25H27ClN4O3	1
1	IC50 = 441 nM Bioactivity Info	TI LI LO TS
CP0415392 Compound Info	3-Chloro-4-hydroxy-benzoic acid {3-chloro-4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-ethoxy]-5-methoxy-benzylidene}-hydrazide Show/Hide	C26H25Cl2N3O4	1
1	IC50 = 485 nM Bioactivity Info	TI LI LO TS
CP0528568 Compound Info	3-(4-((1-(4-phenoxycyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C31H32F3N3O6	1
1	IC50 = 528 nM Bioactivity Info	TI LI LO TS
CP0445452 Compound Info	aminothiazole, 15 Show/Hide	C30H27Cl2N3O3S	1
1	IC50 = 531 nM Bioactivity Info	TI LI LO TS
CP0436887 Compound Info	3-(4-((1-(4-cyclopropylidenecyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C28H30F3N3O5	1
1	IC50 = 571 nM Bioactivity Info	TI LI LO TS
CP0469272 Compound Info	3-Chloro-4-hydroxy-benzoic acid (1-benzyl-1H-indol-3-ylmethylene)-hydrazide Show/Hide	C23H18ClN3O2	1
1	IC50 = 615 nM Bioactivity Info	TI LI LO TS
CP0423785 Compound Info	(R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoylamino}-2-methoxypropionic acid Show/Hide	C31H31Cl2N3O5	1
1	IC50 = 693 nM Bioactivity Info	TI LI LO TS
CP0518066 Compound Info	3-(4-((1-(4-(diethylcarbamoyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C30H37F3N4O6	1
1	IC50 = 782 nM Bioactivity Info	TI LI LO TS
CP0502727 Compound Info	1-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzoyl)piperidine-3-carboxylic acid Show/Hide	C32H40F3N3O5	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0518069 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[(4-cyanophenyl)carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C29H36N4O4	1
1	IC50 = 1045 nM Bioactivity Info	TI LI LO TS
CP0502728 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-(phenylcarbamoyl)amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C28H37N3O4	1
1	IC50 = 1088 nM Bioactivity Info	TI LI LO TS
CP0377322 Compound Info	3-{4-[1-(1,4-dioxa-spiro[4.5]dec-8-yl)-3-(4-trifluoromethoxy-phenyl)-ureidomethyl]-benzoylamino}-propionic acid Show/Hide	C27H30F3N3O7	1
1	IC50 = 1207 nM Bioactivity Info	TI LI LO TS
CP0377321 Compound Info	2-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)acetic acid Show/Hide	C28H34F3N3O5	1
1	IC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0502036 Compound Info	3-[[4-[[[1-(cyclopropanecarbonyl)piperidin-4-yl]-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C28H31F3N4O6	1
1	IC50 = 1984 nM Bioactivity Info	TI LI LO TS
CP0502037 Compound Info	3-[[4-[[(4-tert-butylcyclohexyl)-[[4-(diethylcarbamoyl)phenyl]carbamoyl]amino]methyl]benzoyl]amino]propanoic acid Show/Hide	C33H46N4O5	1
1	IC50 = 2429 nM Bioactivity Info	TI LI LO TS
CP0559887 Compound Info	2-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-indol-1-yl}-N,N-diethyl-acetamide Show/Hide	C22H23ClN4O3	1
1	IC50 = 2540 nM Bioactivity Info	TI LI LO TS
CP0518065 Compound Info	1-(4-((2-(hydroxyamino)-2-oxoethyl)carbamoyl)benzyl)-1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)urea Show/Hide	C28H35F3N4O5	1
1	IC50 = 2960 nM Bioactivity Info	TI LI LO TS
CP0254262 Compound Info	3-(4-((2-chloro-N-(3,3-diphenylpropyl)nicotinamido)methyl)benzamido)propanoic acid Show/Hide	C32H30ClN3O4	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0428128 Compound Info	1-(4-((3-amino-3-oxopropyl)carbamoyl)benzyl)-1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)urea Show/Hide	C29H37F3N4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0436885 Compound Info	4-(1-(4-((2-carboxyethyl)carbamoyl)benzyl)-3-(4-(trifluoromethoxy)phenyl)ureido)cyclohexanecarboxylic acid Show/Hide	C26H28F3N3O7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0459753 Compound Info	4-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)butanoic acid Show/Hide	C30H38F3N3O5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0459754 Compound Info	1-(4-((3-methoxypropyl)carbamoyl)benzyl)-1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)urea Show/Hide	C30H40F3N3O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0526963 Compound Info	3-(4-((1-(4-((cyclopropylmethyl)carbamoyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C30H35F3N4O6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0536726 Compound Info	3-(4-((1-(4-(methylcarbamoyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C27H31F3N4O6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0538462 Compound Info	3-(4-((1-(4-methoxycyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid Show/Hide	C26H30F3N3O6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0553735 Compound Info	3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)-3-methylbutanoic acid Show/Hide	C31H40F3N3O5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0521152 Compound Info	2-(5-tert-Butyl-1H-benzoimidazol-2-ylsulfanyl)-1-(3,4-dihydroxy-phenyl)-ethanone Show/Hide	C19H20N2O3S	1
1	Ki = 5400 nM Bioactivity Info	TI LI LO TS
CP0454700 Compound Info	3-{2-[2-(3-Chloro-4-hydroxy-phenyl)-2-oxo-ethylsulfanyl]-1H-benzoimidazol-5-yloxymethyl}-benzoic acid methyl ester Show/Hide	C24H19ClN2O5S	1
1	Ki = 9200 nM Bioactivity Info	TI LI LO TS
CP0429195 Compound Info	2-(1H-Benzoimidazol-2-ylsulfanyl)-1-(3-chloro-4-hydroxy-phenyl)-ethanone Show/Hide	C15H11ClN2O2S	1
1	Ki = 12000 nM Bioactivity Info	TI LI LO TS
CP0514146 Compound Info	3-{2-[2-(3,4-Dihydroxy-phenyl)-2-oxo-ethylsulfanyl]-1H-benzoimidazol-5-yloxymethyl}-benzoic acid methyl ester Show/Hide	C24H20N2O6S	1
1	Ki = 16000 nM Bioactivity Info	TI LI LO TS
CP0461879 Compound Info	2-(5-Benzyloxy-1H-benzoimidazol-2-ylsulfanyl)-1-(3,4-dihydroxy-phenyl)-ethanone Show/Hide	C22H18N2O4S	1
1	Ki = 18000 nM Bioactivity Info	TI LI LO TS
CP0448583 Compound Info	2-(5,6-Dichloro-1H-benzoimidazol-2-ylsulfanyl)-1-(3,4-dihydroxy-phenyl)-ethanone Show/Hide	C15H10Cl2N2O3S	1
1	Ki = 20000 nM Bioactivity Info	TI LI LO TS
CP0356960 Compound Info	2-(1H-Benzoimidazol-2-ylsulfanyl)-1-(3,4-dihydroxy-phenyl)-ethanone Show/Hide	C15H12N2O3S	1
1	Ki = 20000 nM Bioactivity Info	TI LI LO TS
CP0524124 Compound Info	2-(1H-Benzoimidazol-2-ylsulfanyl)-1-(4-hydroxy-3-methoxy-phenyl)-ethanone Show/Hide	C16H14N2O3S	1
1	Ki = 41000 nM Bioactivity Info	TI LI LO TS
CP0329730 Compound Info	1-(3,4-dihydroxyphenyl)-2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]ethanone Show/Hide	C16H14N2O4S	1
1	Ki = 42000 nM Bioactivity Info	TI LI LO TS
CP0044776 Compound Info	1-(3,4-Dihydroxy-phenyl)-2-(5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethanone Show/Hide	C16H13N3O3S	1
1	Ki = 55000 nM Bioactivity Info	TI LI LO TS
CP0483065 Compound Info	1-(3,4-Dihydroxy-phenyl)-2-(5-nitro-1H-benzoimidazol-2-ylsulfanyl)-ethanone Show/Hide	C15H11N3O5S	1
1	Ki = 55000 nM Bioactivity Info	TI LI LO TS
CP0392592 Compound Info	2-(1H-Benzoimidazol-2-ylsulfanyl)-1-(4-hydroxy-phenyl)-ethanone Show/Hide	C15H12N2O2S	1
1	Ki > 60000 nM Bioactivity Info	TI LI LO TS
CP0148841 Compound Info	2-(Benzothiazol-2-ylsulfanyl)-1-(3,4-dihydroxy-phenyl)-ethanone Show/Hide	C15H11NO3S2	1
1	Ki = 73000 nM Bioactivity Info	TI LI LO TS
CP0534850 Compound Info	3-{2-[2-(3,4-Dihydroxy-phenyl)-2-oxo-ethylsulfanyl]-1H-benzoimidazol-5-yloxymethyl}-benzoic acid Show/Hide	C23H18N2O6S	1
1	Ki = 95000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0134277 Compound Info	3-Cyano-4-hydroxy-benzoic acid [1-(2,3,5,6-tetramethyl-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C28H26N4O2	1
1	IC50 = 2.3 nM
CP0036234 Compound Info	4-[2-(4-Chloro-phenyl)-5-(2-phenoxy-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C26H18ClN3O	2
1	IC50 = 6.5 nM
2	IC50 = 290 nM
CP0036294 Compound Info	4-[2-(4-Chloro-phenyl)-5-(3-phenoxy-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C26H18ClN3O	2
1	IC50 = 13 nM
2	IC50 = 150 nM
CP0215714 Compound Info	4-[2-(4-Chloro-phenyl)-5-(2,4-dipropoxy-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C26H26ClN3O2	2
1	IC50 = 13 nM
2	IC50 = 120 nM
CP0045459 Compound Info	3-Cyano-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-benzyloxy)-3,5-dimethoxy-phenyl]-meth-(E)-ylidene]-hydrazide Show/Hide	C27H27N3O5	1
1	IC50 = 20 nM
CP0245745 Compound Info	4-[2-(4-Chloro-phenyl)-5-(4-phenoxy-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C26H18ClN3O	2
1	IC50 = 27 nM
2	IC50 = 110 nM
CP0112393 Compound Info	4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]-benzonitrile Show/Hide	C22H14FN3	1
1	IC50 = 50 nM
CP0144083 Compound Info	4-[3-(4-Fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14FN3O2	1
1	IC50 = 50 nM
CP0358493 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-benzyloxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazide Show/Hide	C28H25ClN2O3	1
1	IC50 = 53 nM
CP0324497 Compound Info	4-[5-Biphenyl-3-yl-2-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C26H18ClN3	2
1	IC50 = 61 nM
2	IC50 > 3000 nM
CP0222549 Compound Info	4-[3-(3-Bromo-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14BrClN2	1
1	IC50 = 80.17 nM
CP0269118 Compound Info	3-Chloro-4-hydroxy-benzoic acid [1-(4-isopropyl-benzyl)-1H-indol-4-ylmethylene]-hydrazide Show/Hide	C26H24ClN3O2	1
1	IC50 = 84 nM
CP0050171 Compound Info	4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]-benzoic acid Show/Hide	C22H15FN2O2	1
1	IC50 = 90.16 nM
CP0223176 Compound Info	(R)-1-[4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-propyl-pyridin-3-yl]-ethanol Show/Hide	C22H30FNO	1
1	IC50 = 110 nM
CP0259487 Compound Info	4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)-1H-imidazol-4-yl]-pyridine Show/Hide	C21H16FN3S	2
1	IC50 = 117.22 nM
2	IC50 = 490 nM
CP0056450 Compound Info	4-[2-(4-Chloro-phenyl)-5-(4-iodo-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C20H13ClIN3	2
1	IC50 = 130 nM
2	IC50 = 750 nM
CP0362260 Compound Info	2-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-naphthalen-1-yloxy}-N,N-diethyl-acetamide Show/Hide	C24H24ClN3O4	1
1	IC50 = 130 nM
CP0297388 Compound Info	4-[5-Biphenyl-4-yl-2-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C26H18ClN3	2
1	IC50 = 140 nM
2	IC50 = 3800 nM
CP0202930 Compound Info	4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14Cl2N2	1
1	IC50 = 160.32 nM
CP0271630 Compound Info	4-[3-(4-Fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C15H11FN2	1
1	IC50 = 160.32 nM
CP0182277 Compound Info	4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H21FN2	1
1	IC50 = 180.3 nM
CP0139955 Compound Info	4-[2,5-Bis-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C20H13Cl2N3	2
1	IC50 = 190 nM
2	IC50 = 2200 nM
CP0155748 Compound Info	5-Fluoro-2-(3-hydroxymethyl-2,6-diisopropyl-5-pentyl-pyridin-4-yl)-phenol Show/Hide	C23H32FNO2	1
1	IC50 = 190 nM
CP0202931 Compound Info	4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]-phenylamine Show/Hide	C21H16FN3	1
1	IC50 = 190.11 nM
CP0129520 Compound Info	3-Chloro-4-hydroxy-benzoic acid (4-hydroxy-naphthalen-1-ylmethylene)-hydrazide Show/Hide	C18H13ClN2O3	1
1	IC50 = 200 nM
CP0051820 Compound Info	4-[5-(4-Chloro-phenyl)-3-phenyl-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H15ClN2	1
1	IC50 = 210.38 nM
CP0222550 Compound Info	4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]-benzoic acid ethyl ester Show/Hide	C24H19FN2O2	1
1	IC50 = 260.02 nM
CP0166177 Compound Info	4-[2-(4-Bromo-phenyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C20H13BrFN3	2
1	IC50 = 270 nM
2	IC50 = 2900 nM
CP0038573 Compound Info	4-[3-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14BrClN2	1
1	IC50 = 300.61 nM
CP0085243 Compound Info	4-[3-(4-Fluoro-phenyl)-5-methyl-1H-pyrrol-2-yl]-pyridine Show/Hide	C16H13FN2	1
1	IC50 = 320.63 nM
CP0222552 Compound Info	4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14F2N2	1
1	IC50 = 340.41 nM
CP0057065 Compound Info	4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C20H13ClFN3	2
1	IC50 = 400 nM
2	IC50 = 3200 nM
CP0063255 Compound Info	4-[5-(2,4-Dichloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H13Cl2FN2	1
1	IC50 = 420.73 nM
CP0313977 Compound Info	4-[5-(3-Chloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14ClFN2	1
1	IC50 = 420.73 nM
CP0357281 Compound Info	4-[5-(4-Chloro-phenyl)-3-(3-methoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C22H17ClN2O	1
1	IC50 = 420.73 nM
CP0276117 Compound Info	4-[5-(4-Fluoro-phenyl)-2-(4-iodo-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C20H13FIN3	1
1	IC50 = 510 nM
CP0088613 Compound Info	4-[5-(4-Fluoro-phenyl)-2-(4-isopropyl-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C23H20FN3	1
1	IC50 = 700 nM
CP0213431 Compound Info	[4-(4-fluorophenyl)-5-pentyl-2,6-di(propan-2-yl)pyridin-3-yl]methanol Show/Hide	C23H32FNO	1
1	IC50 = 700 nM
CP0329193 Compound Info	4-[2-(4-Bromo-phenyl)-5-phenyl-3H-imidazol-4-yl]-pyridine Show/Hide	C20H14BrN3	1
1	IC50 = 782 nM
CP0337062 Compound Info	4-[3-(4-Fluoro-phenyl)-5-phenyl-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H15FN2	1
1	IC50 = 801.68 nM
CP0287590 Compound Info	4-[3-(2-Bromo-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14BrClN2	1
1	IC50 = 1000 nM
CP0286734 Compound Info	4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-3-methyl-pyridine Show/Hide	C21H15ClFN3	1
1	IC50 = 1100 nM
CP0310029 Compound Info	4-[5-(4-Chloro-phenyl)-3-(4-methoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C22H17ClN2O	1
1	IC50 = 1150.8 nM
CP0324127 Compound Info	4-[5-(4-Fluoro-phenyl)-2-p-tolyl-3H-imidazol-4-yl]-pyridine Show/Hide	C21H16FN3	1
1	IC50 = 1300 nM
CP0101935 Compound Info	4-[5-(4-Ethyl-phenyl)-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C23H19FN2	1
1	IC50 = 1361.44 nM
CP0303465 Compound Info	4-[2-(3-Bromo-phenyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C20H13BrFN3	1
1	IC50 = 1400 nM
CP0050873 Compound Info	(2,6-Diisopropyl-5-pentyl-4-phenyl-pyridin-3-yl)-methanol Show/Hide	C23H33NO	1
1	IC50 = 1400 nM
CP0096778 Compound Info	4-[5-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14ClFN2	1
1	IC50 = 1402.81 nM
CP0039137 Compound Info	4-[3-(5-Bromo-2-propoxy-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H20BrClN2O	1
1	IC50 = 1442.12 nM
CP0078098 Compound Info	4-[5-(4-Fluoro-phenyl)-2-naphthalen-1-yl-3H-imidazol-4-yl]-pyridine Show/Hide	C24H16FN3	1
1	IC50 = 1500 nM
CP0222551 Compound Info	4-[3-(4-Fluoro-phenyl)-5-p-tolyl-1H-pyrrol-2-yl]-pyridine Show/Hide	C22H17FN2	1
1	IC50 = 1690.44 nM
CP0082326 Compound Info	4-[2,5-Bis-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C20H13F2N3	1
1	IC50 = 2000 nM
CP0170867 Compound Info	4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-phenylamine Show/Hide	C20H15FN4	1
1	IC50 = 2000 nM
CP0095585 Compound Info	4-[2-(5-Bromo-thiophen-2-yl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C18H11BrFN3S	1
1	IC50 = 2200 nM
CP0115930 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-methoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C22H17ClN2O	1
1	IC50 = 2654.61 nM
CP0295139 Compound Info	4-[3-(4-Fluoro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C22H17FN2O	1
1	IC50 = 2805.43 nM
CP0222548 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-propoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H21ClN2O	1
1	IC50 = 2844.46 nM
CP0222546 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-isobutoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C25H23ClN2O	1
1	IC50 = 3767.04 nM
CP0222547 Compound Info	4-[3-(2-Allyloxy-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H19ClN2O	1
1	IC50 = 4742.42 nM
CP0049626 Compound Info	[4-(4-fluorophenyl)-5-(2-methylprop-1-enyl)-2,6-di(propan-2-yl)pyridin-3-yl]methanol Show/Hide	C22H28FNO	1
1	IC50 = 7000 nM
CP0328303 Compound Info	4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-benzonitrile Show/Hide	C21H13FN4	1
1	IC50 = 8000 nM
CP0345817 Compound Info	4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-benzoic acid methyl ester Show/Hide	C22H16FN3O2	1
1	IC50 = 8700 nM
CP0217515 Compound Info	4-[2-Biphenyl-4-yl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C26H18FN3	1
1	IC50 = 10000 nM
CP0139965 Compound Info	4-[5-(4-Fluoro-phenyl)-2-(4-methoxy-phenyl)-3H-imidazol-4-yl]-pyridine Show/Hide	C21H16FN3O	1
1	IC50 = 13000 nM
CP0280722 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C23H19ClN2O	1
1	IC50 = 14223.29 nM
CP0057386 Compound Info	4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-pyridine Show/Hide	C20H14FN3	1
1	IC50 > 20000 nM
CP0406422 Compound Info	US8748624, 43 Show/Hide	C31H24ClF6N3O3	1
1	Ki = 17.2 nM
CP0047783 Compound Info	3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluoromethoxy-phenyl)-ureidomethyl]-benzoylamino}-propionic acid Show/Hide	C29H36F3N3O5	1
1	Ki = 63 nM
CP0120350 Compound Info	3-[[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acid Show/Hide	C32H27Cl2N3O4	1
1	Ki = 70 nM
CP0070503 Compound Info	(R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid Show/Hide	C30H29Cl2N3O5	1
1	Ki = 85 nM

Clinical Information about the Protein

Target 1 ( Glucagon receptor (GCGR) )

Target Type	Successful Target
Disease	3 Target-related Diseases				3
1	Hypoglycemia [ICD-11: 5A41]
2	Type-2 diabetes [ICD-11: 5A11]
3	Diabetic complication [ICD-11: 5A2Y]
Approved Drug(s)	1 Approved Drug				1
1	Glucagon recombinant	Drug Info	Approved	Hypoglycemia
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	PF-06291874	Drug Info	Phase 2	Type-2 diabetes
Discontinued Drug(s)	1 Discontinued Drug				1
1	BAY-27-9955	Drug Info	Discontinued in Phase 1	Type-2 diabetes
Investigative Drug(s)	1 Investigative Drug				1
1	L-168049	Drug Info	Investigative	Diabetic complication

Target 2 ( Glucagon receptor messenger RNA (GCGR mRNA) )

Target Type	Clinical trial Target

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT00676	Glucagon receptor	Macaca mulatta, Rhesus macaque	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han