General Information of the Protein
| Protein ID |
PT01446
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| Protein Name |
Interleukin-8
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| Secondarily Protein Name |
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Emoctakin
Granulocyte chemotactic protein 1
Monocyte-derived neutrophil chemotactic factor
Monocyte-derived neutrophil-activating peptide
Neutrophil-activating protein 1
Protein 3-10C
T-cell chemotactic factor
GCP/IL-8 protein IV
IL8/NAP1 form I
(Ala-IL-8)77
GCP/IL-8 protein II
IL-8(1-77)
IL8/NAP1 form II
MDNCF-b
(Ser-IL-8)72
GCP/IL-8 protein I
IL8/NAP1 form III
Lymphocyte-derived neutrophil-activating factor
MDNCF-c
Neutrophil-activating factor
GCP/IL-8 protein V
IL8/NAP1 form IV
GCP/IL-8 protein VI
IL8/NAP1 form V
GCP/IL-8 protein III
IL8/NAP1 form VI
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| Gene Name |
CXCL8
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| Secondarily Gene Name |
IL8
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| Sequence |
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Secreted protein
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| Function |
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:7636208, PubMed:18692776). Also plays an important role in neutrophil activation (PubMed:9623510, PubMed:2145175). Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells (PubMed:1840701, PubMed:1891716). G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways (PubMed:8662698, PubMed:11971003).
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Secreted
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000892 , MCF-7/NOD1
Cell Line ID: CL000797 , MCF-7/NOD2
Clinical Information about the Protein
Target 1 ( Interleukin-8 (IL8) )
| Target Type | Successful Target | ||||
|---|---|---|---|---|---|
| Disease | 1 Target-related Disease | 1 | |||
| 1 | Pain [ICD-11: MG30-MG3Z] | ||||
| Approved Drug(s) | 1 Approved Drug | 1 | |||
| 1 | Ibuprofen | Approved | |||
Target 2 ( HUMAN interleukin 8 (IL8) )
| Target Type | Unknown Type Target | ||||
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