General Information of the Compound
Compound ID
CP0360366
Compound Name
7-[(E)-but-2-enyl]-3-methyl-8-(phenylmethylsulfanyl)purine-2,6-dione
    Show/Hide
Structure
Formula
C17H18N4O2S
Molecular Weight
342.424
Canonical SMILES
C\C=C\Cn1c(SCc2ccccc2)nc2n(C)c(=O)[nH]c(=O)c12
    Show/Hide
InChI
InChI=1S/C17H18N4O2S/c1-3-4-10-21-13-14(20(2)16(23)19-15(13)22)18-17(21)24-11-12-8-6-5-7-9-12/h3-9H,10-11H2,1-2H3,(H,19,22,23)/b4-3+
    Show/Hide
InChIKey
TZABDFYHNLGMHW-ONEGZZNKSA-N
Physicochemical Property
logP
2.2917
Rotatable Bonds
5
Heavy Atom Count
24
Polar Areas
72.68
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 5761203
ChEMBL ID
CHEMBL1448844
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01446, Interleukin-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000892 MCF-7/NOD1 Homo sapiens (Human)  1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS