General Information of the Protein
Protein ID
PT01440
Protein Name
Melanocyte-stimulating hormone receptor
Secondarily
Protein Name
Melanocortin receptor 1
Gene Name
MC1R
Secondarily
Gene Name
Msh-r
Sequence
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Melanocortin receptor
Function
Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).
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Uniprot ID
Primary ID:
Q01727

Secondarily ID:
Q75NA3
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000087 , B16
Compound ID Compound Name Compound Formula
CP0435764
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-chloro-4,5-dimethoxyphenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C41H52ClN3O4
 1
1
Ki = 630 nM
   TI
   LI
   LO
   TS
CP0421954
(E)-N-(5-aminopentyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
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C26H32ClN3O
 1
1
Ki = 770 nM
   TI
   LI
   LO
   TS
CP0457946
(E)-N-(3-aminopropyl)-N-(2-methyl-3-phenylallyl)-1H-indole-3-carboxamide
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C22H25N3O
 1
1
Ki = 850 nM
   TI
   LI
   LO
   TS
CP0424314
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(E)-3-(2-bromo-4,5-dimethoxyphenyl)prop-2-enyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C43H54BrN3O4
 1
1
Ki = 940 nM
   TI
   LI
   LO
   TS
CP0425715
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-fluorophenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C39H48FN3O2
 1
1
Ki = 1000 nM
   TI
   LI
   LO
   TS
CP0464549
(Z)-N-(3-aminopropyl)-N-(2-chloro-3-phenylallyl)-2-(1H-indol-3-yl)-2-oxoacetamide
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C22H22ClN3O2
 1
1
Ki = 1000 nM
   TI
   LI
   LO
   TS
CP0437203
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-chloro-6-fluorophenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C39H47ClFN3O2
 1
1
Ki = 1100 nM
   TI
   LI
   LO
   TS
CP0421934
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-(1H-indol-3-yl)-N-[(2-methylphenyl)methyl]butanamide
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C33H45N3O
 1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS
CP0442500
N-(8-aminooctyl)-3-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]propanamide
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C28H37N3O
 1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS
CP0421910
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-(1H-indol-3-yl)-N-[(3-methylphenyl)methyl]butanamide
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C33H45N3O
 1
1
Ki = 1300 nM
   TI
   LI
   LO
   TS
CP0464452
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-(1H-indol-3-yl)-N-[(4-methylphenyl)methyl]butanamide
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C33H45N3O
 1
1
Ki = 1300 nM
   TI
   LI
   LO
   TS
CP0435763
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(4-cyanophenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C40H48N4O2
 1
1
Ki = 1400 nM
   TI
   LI
   LO
   TS
CP0421930
N-benzyl-N-[4-[[4-(diaminomethylideneamino)cyclohexyl]methyl]cyclohexyl]-4-(1H-indol-3-yl)butanamide
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C33H45N5O
 1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
CP0425721
(Z)-N-((3-(aminomethyl)cyclohexyl)methyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
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C29H36ClN3O
 1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
CP0442983
N-[[3-(aminomethyl)phenyl]methyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
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C31H31N3O
 1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
CP0457962
N-(5-aminopentyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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C26H29N3O
 1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
CP0421734
N-(2-aminoethyl)-2-naphthalen-2-yl-N-(1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
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C24H26N2O
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0437201
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2,6-dichlorophenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C39H47Cl2N3O2
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0449489
(Z)-N-((4-(aminomethyl)cyclohexyl)methyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
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C29H36ClN3O
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0462571
N-(3-aminopropyl)-2-(1H-indol-3-yl)-2-oxo-N-[(E)-3-phenylprop-2-enyl]acetamide
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C22H23N3O2
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0439614
N-(4-aminobutyl)-N-(naphthalen-2-ylmethyl)-1H-indole-3-carboxamide
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C24H25N3O
 1
1
Ki = 1700 nM
   TI
   LI
   LO
   TS
CP0421957
(E)-N-(4-aminobutyl)-2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-(2-methyl-3-phenylallyl)acetamide
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C33H36ClN3O3
 1
1
Ki = 1800 nM
   TI
   LI
   LO
   TS
CP0437891
(E)-N-(3-aminopropyl)-2-(1H-indol-3-yl)-N-(2-methyl-3-phenylallyl)-2-oxoacetamide
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C23H25N3O2
 1
1
Ki = 1800 nM
   TI
   LI
   LO
   TS
CP0461946
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2,6-difluorophenyl)methyl]-4-(1H-indol-3-yl)butanamide
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C32H41F2N3O
 1
1
Ki = 1800 nM
   TI
   LI
   LO
   TS
CP0528387
1-(3-aminocyclohexyl)-3-((1r,4r)-4-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea
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C32H43N5O2
 1
1
Ki = 1800 nM
   TI
   LI
   LO
   TS
CP0424308
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(3,4-dimethoxyphenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C41H53N3O4
 1
1
Ki = 1900 nM
   TI
   LI
   LO
   TS
CP0437836
N-[[3-(aminomethyl)phenyl]methyl]-N-benzyl-4-(1H-indol-3-yl)butanamide
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C27H29N3O
 1
1
Ki = 1900 nM
   TI
   LI
   LO
   TS
CP0465235
N-[3-(diaminomethylideneamino)propyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
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C27H31N5O
 1
1
Ki = 1900 nM
   TI
   LI
   LO
   TS
CP0421931
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(E)-3-(2-bromo-4,5-dimethoxyphenyl)prop-2-enyl]-4-(1H-indol-3-yl)butanamide
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C36H48BrN3O3
 1
1
Ki = 2000 nM
   TI
   LI
   LO
   TS
CP0425718
4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(5-aminopentyl)-N-benzylbutanamide
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C31H37N3O2
 1
1
Ki = 2000 nM
   TI
   LI
   LO
   TS
CP0437204
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[2-(2-chloro-6-fluorophenyl)ethyl]-4-(1H-indol-3-yl)butanamide
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C33H43ClFN3O
 1
1
Ki = 2100 nM
   TI
   LI
   LO
   TS
CP0442985
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2,6-difluorophenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C39H47F2N3O2
 1
1
Ki = 2100 nM
   TI
   LI
   LO
   TS
CP0496747
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(3-ethoxy-4-methoxyphenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C42H55N3O4
 1
1
Ki = 2100 nM
   TI
   LI
   LO
   TS
CP0511019
methyl 4-[[[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-[4-(1H-indol-3-yl)butanoyl]amino]methyl]benzoate
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C34H45N3O3
 1
1
Ki = 2100 nM
   TI
   LI
   LO
   TS
CP0449788
1-(3-aminocyclohexyl)-3-(3-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea
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C32H43N5O2
 1
1
Ki = 2200 nM
   TI
   LI
   LO
   TS
CP0421800
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-(1H-indol-3-yl)butanamide
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C34H46BrN3O3
 1
1
Ki = 2300 nM
   TI
   LI
   LO
   TS
CP0461944
4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(6-aminohexyl)-N-benzylbutanamide
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C32H39N3O2
 1
1
Ki = 2300 nM
   TI
   LI
   LO
   TS
CP0421732
N-(3-aminopropyl)-2-(1H-indol-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
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C23H27N3O
 1
1
Ki = 2400 nM
   TI
   LI
   LO
   TS
CP0421912
(Z)-N-(6-aminohexyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
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C27H34ClN3O
 1
1
Ki = 2400 nM
   TI
   LI
   LO
   TS
CP0442485
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-fluorophenyl)methyl]-4-(1H-indol-3-yl)butanamide
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C32H42FN3O
 1
1
Ki = 2400 nM
   TI
   LI
   LO
   TS
CP0449787
(Z)-N-(4-aminobutyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
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C25H30ClN3O
 1
1
Ki = 2400 nM
   TI
   LI
   LO
   TS
CP0421922
N-(3-aminopropyl)-2-naphthalen-2-yl-N-[(E)-3-phenylprop-2-enyl]acetamide
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C24H26N2O
 1
1
Ki = 2500 nM
   TI
   LI
   LO
   TS
CP0436520
N-[[4-(aminomethyl)cyclohexyl]methyl]-N-benzyl-4-(1H-indol-3-yl)butanamide
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C27H35N3O
 1
1
Ki = 2500 nM
   TI
   LI
   LO
   TS
CP0436532
(E)-N-(5-aminopentyl)-4-(1H-indol-3-yl)-N-(3-(naphthalen-2-yl)prop-1-enyl)butanamide
   Show/Hide
C30H35N3O
 1
1
Ki = 2500 nM
   TI
   LI
   LO
   TS
CP0437202
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2,6-dichlorophenyl)methyl]-4-(1H-indol-3-yl)butanamide
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C32H41Cl2N3O
 1
1
Ki = 2500 nM
   TI
   LI
   LO
   TS
CP0421908
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(3-bromo-4-methoxyphenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
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C40H50BrN3O3
 1
1
Ki = 2600 nM
   TI
   LI
   LO
   TS
CP0457945
N-(5-aminopentyl)-2-(1H-indol-3-yl)-N-[1-[4-(trifluoromethyl)phenyl]ethyl]acetamide
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C24H28F3N3O
 1
1
Ki = 2600 nM
   TI
   LI
   LO
   TS
CP0464521
N-[[4-(aminomethyl)phenyl]methyl]-4-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]butanamide
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C29H31N3O
 1
1
Ki = 2600 nM
   TI
   LI
   LO
   TS
CP0437834
N-[[3-(aminomethyl)cyclohexyl]methyl]-N-benzyl-4-(1H-indol-3-yl)butanamide
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C27H35N3O
 1
1
Ki = 2700 nM
   TI
   LI
   LO
   TS
CP0439612
(E)-N-(5-aminopentyl)-3-(1H-indol-3-yl)-N-((Z)-2-methyl-3-phenylallyl)acrylamide
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C26H31N3O
 1
1
Ki = 2700 nM
   TI
   LI
   LO
   TS
CP0449484
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]butanamide
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C34H45N3O
 1
1
Ki = 2700 nM
   TI
   LI
   LO
   TS
CP0449488
1-((1r,4r)-4-aminocyclohexyl)-3-(3-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea
   Show/Hide
C32H43N5O2
 1
1
Ki = 2700 nM
   TI
   LI
   LO
   TS
CP0464538
(E)-N-(5-aminopentyl)-N-((E)-2-chloro-3-phenylallyl)-3-(1H-indol-3-yl)acrylamide
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C25H28ClN3O
 1
1
Ki = 2700 nM
   TI
   LI
   LO
   TS
CP0428485
3-((R,E)-7-methyl-5-((1r,4R)-4-methylcyclohexyl)-4-methylene-8-phenyloct-7-enyl)-1H-indene
   Show/Hide
C27H32ClN3O
 1
1
Ki = 2800 nM
   TI
   LI
   LO
   TS
CP0528589
(Z)-N-(3-aminocyclohexyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
   Show/Hide
C27H32ClN3O
 1
1
Ki = 2800 nM
   TI
   LI
   LO
   TS
CP0435767
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(3-bromo-4-methoxyphenyl)methyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C33H44BrN3O2
 1
1
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0437205
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(3-ethoxy-4-methoxyphenyl)methyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C35H49N3O3
 1
1
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0439615
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]-N-[(3-methylphenyl)methyl]butanamide
   Show/Hide
C40H51N3O2
 1
1
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0449483
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
   Show/Hide
C41H52BrN3O4
 1
1
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0461942
N-(6-aminohexyl)-5-hydroxy-N-(2-methyl-3-phenylpropyl)-1H-indole-2-carboxamide
   Show/Hide
C25H33N3O2
 1
1
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0464511
1-(3-(4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-benzylbutanamido)cyclohexyl)-3-(3-aminocyclohexyl)urea
   Show/Hide
C39H49N5O3
 1
1
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0428482
(Z)-N-(5-aminopentyl)-4-(1H-indol-3-yl)-N-(3-phenylallyl)butanamide
   Show/Hide
C26H33N3O
 1
1
Ki = 3000 nM
   TI
   LI
   LO
   TS
CP0421799
(Z)-1-(3-aminocyclohexyl)-3-(3-(N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea
   Show/Hide
C34H44ClN5O2
 1
1
Ki = 3100 nM
   TI
   LI
   LO
   TS
CP0428488
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(Z)-2-chloro-3-phenylprop-2-enyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C34H44ClN3O
 1
1
Ki = 3100 nM
   TI
   LI
   LO
   TS
CP0457938
N-(1-adamantyl)-N-(4-aminobutyl)-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetamide
   Show/Hide
C33H40ClN3O3
 1
1
Ki = 3100 nM
   TI
   LI
   LO
   TS
CP0421730
N-(5-aminopentyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C24H31N3O
 1
1
Ki = 3200 nM
   TI
   LI
   LO
   TS
CP0421803
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-(1H-indol-3-yl)-N-[(4-methylsulfanylphenyl)methyl]butanamide
   Show/Hide
C33H45N3OS
 1
1
Ki = 3200 nM
   TI
   LI
   LO
   TS
CP0425716
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(3,4-dimethoxyphenyl)methyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C34H47N3O3
 1
1
Ki = 3200 nM
   TI
   LI
   LO
   TS
CP0436525
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-chlorophenyl)methyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C32H42ClN3O
 1
1
Ki = 3200 nM
   TI
   LI
   LO
   TS
CP0437889
N-[4-(diaminomethylideneamino)butyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
   Show/Hide
C28H33N5O
 1
1
Ki = 3200 nM
   TI
   LI
   LO
   TS
CP0442506
N-(2-aminoethyl)-4-(1H-indol-3-yl)-N-spiro[5.5]undecan-3-ylbutanamide
   Show/Hide
C25H37N3O
 1
1
Ki = 3200 nM
   TI
   LI
   LO
   TS
CP0436531
(Z)-3-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(5-aminopentyl)-N-(3-phenylallyl)propanamide
   Show/Hide
C32H37N3O2
 1
1
Ki = 3300 nM
   TI
   LI
   LO
   TS
CP0437835
N-(3-aminocyclohexyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C25H31N3O
 1
1
Ki = 3300 nM
   TI
   LI
   LO
   TS
CP0437206
(Z)-N-(5-aminopentyl)-4-(1H-indol-3-yl)-N-(2-methyl-3-phenylallyl)butanamide
   Show/Hide
C27H35N3O
 1
1
Ki = 3500 nM
   TI
   LI
   LO
   TS
CP0496754
N-[4-[[4-(diaminomethylideneamino)cyclohexyl]methyl]cyclohexyl]-4-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]butanamide
   Show/Hide
C35H47N5O
 1
1
Ki = 3500 nM
   TI
   LI
   LO
   TS
CP0442499
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-bromophenyl)methyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C32H42BrN3O
 1
1
Ki = 3600 nM
   TI
   LI
   LO
   TS
CP0493563
N-(2-aminoethyl)-N-(naphthalen-2-ylmethyl)-1H-indole-3-carboxamide
   Show/Hide
C22H21N3O
 1
1
Ki = 3600 nM
   TI
   LI
   LO
   TS
CP0421955
N-(5-aminopentyl)-3-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]propanamide
   Show/Hide
C25H31N3O
 1
1
Ki = 3700 nM
   TI
   LI
   LO
   TS
CP0424311
N-(3-aminopropyl)-3-(1H-indol-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)propanamide
   Show/Hide
C24H29N3O
 1
1
Ki = 3700 nM
   TI
   LI
   LO
   TS
CP0436526
N-(3-aminopropyl)-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
   Show/Hide
C26H29N3O
 1
1
Ki = 3700 nM
   TI
   LI
   LO
   TS
CP0442505
(R)-2-amino-N-(2-amino-ethyl)-3-(4-chloro-phenyl)-N-spiro[5.5]undec-3-yl-propionamide
   Show/Hide
C22H34ClN3O
 1
1
Ki = 3700 nM
   TI
   LI
   LO
   TS
CP0464537
(E)-N-(6-aminohexyl)-5-hydroxy-N-(2-methyl-3-phenylallyl)-1H-indole-2-carboxamide
   Show/Hide
C25H31N3O2
 1
1
Ki = 3700 nM
   TI
   LI
   LO
   TS
CP0442490
(R)-2-amino-N-(5-amino-pentyl)-N-benzyl-3-biphenyl-4-yl-propionamide
   Show/Hide
C27H33N3O
 1
1
Ki = 3900 nM
   TI
   LI
   LO
   TS
CP0449789
N-[[4-(aminomethyl)phenyl]methyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
   Show/Hide
C31H31N3O
 1
1
Ki = 4000 nM
   TI
   LI
   LO
   TS
CP0457940
N-(2-aminoethyl)-2-(1H-indol-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
   Show/Hide
C22H25N3O
 1
1
Ki = 4000 nM
   TI
   LI
   LO
   TS
CP0480359
N-(7-aminoheptyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C26H35N3O
 1
1
Ki = 4000 nM
   TI
   LI
   LO
   TS
CP0424317
(Z)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-5-(benzyloxy)-N-(2-chloro-3-phenylallyl)-1H-indole-2-carboxamide
   Show/Hide
C38H44ClN3O2
 1
1
Ki = 4200 nM
   TI
   LI
   LO
   TS
CP0421804
methyl 4-[[[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-[4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanoyl]amino]methyl]benzoate
   Show/Hide
C41H51N3O4
 1
1
Ki = 4300 nM
   TI
   LI
   LO
   TS
CP0437212
N-(4-aminocyclohexyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C25H31N3O
 1
1
Ki = 4300 nM
   TI
   LI
   LO
   TS
CP0421936
N-(2-aminoethyl)-2-(1H-indol-3-yl)-N-(1-naphthalen-2-ylethyl)acetamide
   Show/Hide
C24H25N3O
 1
1
Ki = 4400 nM
   TI
   LI
   LO
   TS
CP0442984
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-(1H-indol-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)butanamide
   Show/Hide
C35H47N3O
 1
1
Ki = 4500 nM
   TI
   LI
   LO
   TS
CP0522273
N-(5-aminopentyl)-2-(1H-indol-3-yl)-N-(2-naphthalen-2-ylethyl)acetamide
   Show/Hide
C27H31N3O
 1
1
Ki = 4500 nM
   TI
   LI
   LO
   TS
CP0436521
(Z)-N-(3-(4-(3-aminopropyl)piperazin-1-yl)propyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
   Show/Hide
C31H42ClN5O
 1
1
Ki = 4600 nM
   TI
   LI
   LO
   TS
CP0437833
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-(1H-indol-3-yl)-N-(pyridin-2-ylmethyl)butanamide
   Show/Hide
C31H42N4O
 1
1
Ki = 4600 nM
   TI
   LI
   LO
   TS
CP0421932
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]-N-[(4-methylphenyl)methyl]butanamide
   Show/Hide
C40H51N3O2
 1
1
Ki = 4700 nM
   TI
   LI
   LO
   TS
CP0421933
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]-N-[(2-methylphenyl)methyl]butanamide
   Show/Hide
C40H51N3O2
 1
1
Ki = 4700 nM
   TI
   LI
   LO
   TS
CP0421733
N-(3-aminopropyl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-indole-3-carboxamide
   Show/Hide
C22H25N3O
 1
1
Ki = 4800 nM
   TI
   LI
   LO
   TS
CP0425719
(R)-2-amino-N-(5-aminopentyl)-N-benzyl-3-(naphthalen-2-yl)propanamide
   Show/Hide
C25H31N3O
 1
1
Ki = 5000 nM
   TI
   LI
   LO
   TS
CP0428483
N-(3-aminopropyl)-2-(1H-indol-3-yl)-N-(3-phenylpropyl)acetamide
   Show/Hide
C22H27N3O
 1
1
Ki = 5000 nM
   TI
   LI
   LO
   TS
CP0449486
(Z)-N-(7-aminoheptyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
   Show/Hide
C28H36ClN3O
 1
1
Ki = 5000 nM
   TI
   LI
   LO
   TS
CP0437839
N-(5-aminopentyl)-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
   Show/Hide
C28H33N3O
 1
1
Ki = 5100 nM
   TI
   LI
   LO
   TS
CP0457936
N-(5-aminopentyl)-N-(1,3-benzodioxol-5-ylmethyl)-4-(1H-indol-3-yl)butanamide
   Show/Hide
C25H31N3O3
 1
1
Ki = 5500 nM
   TI
   LI
   LO
   TS
CP0424318
(Z)-N-(2-aminoethyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide
   Show/Hide
C23H26ClN3O
 1
1
Ki = 5600 nM
   TI
   LI
   LO
   TS
CP0464448
N-(3-aminopropyl)-2-naphthalen-2-yl-N-(naphthalen-2-ylmethyl)acetamide
   Show/Hide
C26H26N2O
 1
1
Ki = 5900 nM
   TI
   LI
   LO
   TS
CP0421915
N-(5-aminopentyl)-N-cycloheptyl-2-(1H-indol-3-yl)acetamide
   Show/Hide
C22H33N3O
 1
1
Ki = 6000 nM
   TI
   LI
   LO
   TS
CP0449480
(E)-N-(3-aminopropyl)-3-(1H-indol-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)acrylamide
   Show/Hide
C24H27N3O
 1
1
Ki = 6000 nM
   TI
   LI
   LO
   TS
CP0464536
N-(2-aminoethyl)-2-naphthalen-2-yloxy-N-spiro[5.5]undecan-3-ylacetamide
   Show/Hide
C25H34N2O2
 1
1
Ki = 6000 nM
   TI
   LI
   LO
   TS
CP0421921
N-(3-aminopropyl)-N-[(Z)-2-chloro-3-phenylprop-2-enyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C24H28ClN3O
 1
1
Ki = 6100 nM
   TI
   LI
   LO
   TS
CP0449487
N-(2-adamantyl)-N-(5-aminopentyl)-4-(1H-indol-3-yl)butanamide
   Show/Hide
C27H39N3O
 1
1
Ki = 6100 nM
   TI
   LI
   LO
   TS
CP0461945
N-(3-aminopropyl)-2-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]acetamide
   Show/Hide
C22H25N3O
 1
1
Ki = 6400 nM
   TI
   LI
   LO
   TS
CP0462573
N-[3-[4-(3-aminopropyl)piperazin-1-yl]propyl]-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C29H41N5O
 1
1
Ki = 6400 nM
   TI
   LI
   LO
   TS
CP0442498
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-N-[(2-chlorophenyl)methyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]butanamide
   Show/Hide
C39H48ClN3O2
 1
1
Ki = 6600 nM
   TI
   LI
   LO
   TS
CP0421920
(E)-N-(3-aminopropyl)-N-(2-methyl-3-phenylallyl)-4-(thiophen-2-yl)butanamide
   Show/Hide
C21H28N2OS
 1
1
Ki = 6800 nM
   TI
   LI
   LO
   TS
CP0442501
N-(5-aminopentyl)-N-[[4-(diethylamino)phenyl]methyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C28H40N4O
 1
1
Ki = 6800 nM
   TI
   LI
   LO
   TS
CP0421923
N-(3-aminopropyl)-N-[1-(1-benzothiophen-3-yl)ethyl]-4-(1H-indol-3-yl)butanamide
   Show/Hide
C25H29N3OS
 1
1
Ki = 7400 nM
   TI
   LI
   LO
   TS
CP0424309
N-(5-aminopentyl)-2-naphthalen-2-yloxy-N-spiro[5.5]undec-9-en-3-ylacetamide
   Show/Hide
C28H38N2O2
 1
1
Ki = 7400 nM
   TI
   LI
   LO
   TS
CP0421917
4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-aminobutyl)-N-benzylbutanamide
   Show/Hide
C30H35N3O2
 1
1
Ki = 7700 nM
   TI
   LI
   LO
   TS
CP0461953
N-[2-(diaminomethylideneamino)ethyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
   Show/Hide
C26H29N5O
 1
1
Ki = 8300 nM
   TI
   LI
   LO
   TS
CP0467838
N-(4-aminobutyl)-3-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]propanamide
   Show/Hide
C24H29N3O
 1
1
Ki = 8300 nM
   TI
   LI
   LO
   TS
CP0437208
(E)-N-(3-aminopropyl)-2-(1H-indol-3-yl)-N-(2-methyl-3-phenylallyl)acetamide
   Show/Hide
C23H27N3O
 1
1
Ki = 9300 nM
   TI
   LI
   LO
   TS
CP0437890
(S)-2-amino-N-(5-aminopentyl)-N-benzyl-3-(naphthalen-2-yl)propanamide
   Show/Hide
C25H31N3O
 1
1
Ki = 10000 nM
   TI
   LI
   LO
   TS
CP0449490
1-((1r,4R)-4-aminocyclohexyl)-3-((1r,4R)-4-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea
   Show/Hide
C32H43N5O2
 1
1
Ki = 11000 nM
   TI
   LI
   LO
   TS
CP0421731
N-(5-aminopentyl)-2-(1H-indol-3-yl)-N-(3-phenylpropyl)acetamide
   Show/Hide
C24H31N3O
 1
1
Ki = 12000 nM
   TI
   LI
   LO
   TS
CP0421743
N-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
   Show/Hide
C26H29N5O
 1
1
Ki = 12000 nM
   TI
   LI
   LO
   TS
CP0425722
N-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
   Show/Hide
C27H31N5O
 1
1
Ki = 12000 nM
   TI
   LI
   LO
   TS
CP0437207
N-(4-aminobutyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C23H29N3O
 1
1
Ki = 12000 nM
   TI
   LI
   LO
   TS
CP0464451
N-[(1R,2R)-2-aminocyclohexyl]-4-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]butanamide
   Show/Hide
C27H33N3O
 1
1
Ki = 12000 nM
   TI
   LI
   LO
   TS
CP0461931
N-(6-aminohexyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C25H33N3O
 1
1
Ki = 13000 nM
   TI
   LI
   LO
   TS
CP0421956
N-(5-aminopentyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
   Show/Hide
C27H31N3O
 1
1
Ki = 14000 nM
   TI
   LI
   LO
   TS
CP0435766
N-[2-(diaminomethylideneamino)ethyl]-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
   Show/Hide
C25H27N5O
 1
1
Ki = 14000 nM
   TI
   LI
   LO
   TS
CP0421748
N-(4-aminobutyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
   Show/Hide
C25H27N3O
 1
1
Ki = 15000 nM
   TI
   LI
   LO
   TS
CP0442503
N-(4-aminobutyl)-3-(1H-indol-3-yl)-N-(1-phenylpropyl)propanamide
   Show/Hide
C24H31N3O
 1
1
Ki = 15000 nM
   TI
   LI
   LO
   TS
CP0425714
N-[4-[(4-aminocyclohexyl)methyl]cyclohexyl]-4-[2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl]-N-[(4-methylsulfanylphenyl)methyl]butanamide
   Show/Hide
C40H51N3O2S
 1
1
Ki = 17000 nM
   TI
   LI
   LO
   TS
CP0435771
N-(2-aminoethyl)-3-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]propanamide
   Show/Hide
C22H25N3O
 1
1
Ki = 17000 nM
   TI
   LI
   LO
   TS
CP0437892
N-(3-aminopropyl)-N-[(E)-3-phenylprop-2-enyl]-1H-indole-3-carboxamide
   Show/Hide
C21H23N3O
 1
1
Ki = 17000 nM
   TI
   LI
   LO
   TS
CP0462022
N-[4-(diaminomethylideneamino)butyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
   Show/Hide
C26H29N5O
 1
1
Ki = 17000 nM
   TI
   LI
   LO
   TS
CP0467201
N-(3-aminopropyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C22H27N3O
 1
1
Ki = 17000 nM
   TI
   LI
   LO
   TS
CP0436541
N-(5-aminopentyl)-4-(1H-indol-3-yl)-N-(3-phenylpropyl)butanamide
   Show/Hide
C26H35N3O
 1
1
Ki = 18000 nM
   TI
   LI
   LO
   TS
CP0436515
N-[2-(diaminomethylideneamino)ethyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
   Show/Hide
C24H25N5O
 1
1
Ki = 19000 nM
   TI
   LI
   LO
   TS
CP0462572
N-(3-aminopropyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
   Show/Hide
C24H25N3O
 1
1
Ki = 20000 nM
   TI
   LI
   LO
   TS
CP0436518
N-(3-aminopropyl)-3-(1H-indol-3-yl)-N-[(E)-3-phenylprop-2-enyl]propanamide
   Show/Hide
C23H27N3O
 1
1
Ki = 21000 nM
   TI
   LI
   LO
   TS
CP0436540
N-(2-aminoethyl)-3-(1H-indol-3-yl)-N-(3-phenylpropyl)propanamide
   Show/Hide
C22H27N3O
 1
1
Ki = 21000 nM
   TI
   LI
   LO
   TS
CP0462565
N-(3-aminopropyl)-4-(1H-indol-3-yl)-N-(2-phenylethyl)butanamide
   Show/Hide
C23H29N3O
 1
1
Ki = 21000 nM
   TI
   LI
   LO
   TS
CP0435765
N-(2-aminoethyl)-N-benzyl-4-(1H-indol-3-yl)butanamide
   Show/Hide
C21H25N3O
 1
1
Ki = 22000 nM
   TI
   LI
   LO
   TS
CP0480353
N-(3-aminopropyl)-5-phenylmethoxy-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
   Show/Hide
C29H31N3O2
 1
1
Ki = 26000 nM
   TI
   LI
   LO
   TS
CP0464447
(R)-2-amino-N-(5-aminopentyl)-N-benzyl-3-(1H-indol-3-yl)propanamide
   Show/Hide
C23H30N4O
 1
1
Ki = 32000 nM
   TI
   LI
   LO
   TS
CP0437214
(S)-2-amino-N-(5-aminopentyl)-N-benzyl-3-(1H-indol-3-yl)propanamide
   Show/Hide
C23H30N4O
 1
1
Ki = 34000 nM
   TI
   LI
   LO
   TS
CP0437832
N-[3-(diaminomethylideneamino)propyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
   Show/Hide
C25H27N5O
 1
1
Ki = 35000 nM
   TI
   LI
   LO
   TS
CP0437209
N-(2-aminoethyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
   Show/Hide
C23H23N3O
 1
1
Ki = 36000 nM
   TI
   LI
   LO
   TS
CP0457944
(R)-2-amino-N-(5-aminopentyl)-N-benzyl-3-(4-nitrophenyl)propanamide
   Show/Hide
C21H28N4O3
 1
1
Ki = 37000 nM
   TI
   LI
   LO
   TS
CP0437831
N-[[4-(diethylamino)phenyl]methyl]-4-(1H-indol-3-yl)-N-pentylbutanamide
   Show/Hide
C28H39N3O
 1
1
Ki = 72000 nM
   TI
   LI
   LO
   TS
CP0442502
2-(4-hydroxybenzyl)-N-(4-aminobutyl)-N-isopropyl-1H-indole-3-carboxamide
   Show/Hide
C23H29N3O2
 1
1
Ki = 90000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0041451
CAS_75921-69-6
   Show/Hide
C78H111N21O19
 2
1 EC50 = 0.018 nM
2 EC50 = 0.038 nM
CP0091326
(3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexanoylamino)-9-benzyl-6-(3-guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18hexaaza-cyclotricosane-23-carboxylic acid amide
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C50H69N15O9
 1
1 EC50 = 0.022 nM
CP0045108
(4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid
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C77H109N21O19S
 2
1 EC50 = 0.5 nM
2 EC50 = 0.55 nM
CP0045745
(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide
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C34H43N11O5
 1
1 EC50 = 20.1 nM
CP0298526
3-{2-[1-[1-[1-acetyl-(5S)-dihydro-1H-5-pyrrolylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-4-amino(imino)methylamino-(1S)-butylcarboxamido]-2-carbamoylethyl}-1H-indole
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C33H43N9O5
 1
1 EC50 = 4250 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00911 Melanocyte-stimulating hormone receptor Homo sapiens, Human