General Information of the Protein
| Protein ID |
PT01430
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| Protein Name |
3-oxo-5-alpha-steroid 4-dehydrogenase 1
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| Secondarily Protein Name |
SR type 1
Steroid 5-alpha-reductase 1
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| Gene Name |
SRD5A1
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| Sequence |
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Oxidoreductase
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| Function |
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
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| Uniprot ID |
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| Subcellular Location |
Microsome membrane
Endoplasmic reticulum membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Cell Line ID: CL001032 , CHO 1827
Cell Line ID: CL000109 , COS-1
Cell Line ID: CL000119 , DU145
Cell Line ID: CL000006 , HEK293
Cell Line ID: CL000141 , LNCaP
Biochemical Assays
Clinical Information about the Protein