Protein Information

General Information of the Protein

Protein ID	PT01274
Protein Name	Adenosine kinase
Secondarily Protein Name	Adenosine 5'-phosphotransferase
Gene Name	ADK
Sequence	MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme
Function	Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Show/Hide
Uniprot ID	Primary ID: P55263 Secondarily ID: B7Z783 B7Z800 O00741 O00742 Q16710 Q5JQ10 Q5JQ11 Q9BTN2 Show/Hide
Ensembl ID	ENSG00000156110
HGNC ID	HGNC:257
Subcellular Location	Nucleus

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000016 , IMR-32

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0071313 Compound Info	(2R,3R,4S,5R)-2-(2-amino-9-iodo-3,5,7-triazabicyclo[4.3.0]nona-1,3,5,8-tetraen-7-yl)-5-methyl-oxolane-3,4-diol Show/Hide	C11H13IN4O3	1
1	IC50 = 22.8 nM Bioactivity Info	TI LI LO TS
CP0528733 Compound Info	5-(4-Bromo-thiophen-2-yl)-6-(3,4-dimethoxy-phenyl)-7-thiophen-2-yl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C23H17BrN4O2S2	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0198332 Compound Info	5-(3-Bromo-phenyl)-7-(6-dimethylamino-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C20H17BrN6	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0550871 Compound Info	5,6-Diphenyl-7-thiophen-2-yl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C23H16N4S	1
1	IC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0103761 Compound Info	5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C22H19BrN6O	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0507642 Compound Info	7-(6-Dimethylamino-pyridin-3-yl)-5,6-diphenyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C26H22N6	1
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0437004 Compound Info	5-(3-Chloro-phenyl)-7-(6-dimethylamino-pyridin-3-yl)-6-phenyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C26H21ClN6	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0518331 Compound Info	5-(3-Chloro-phenyl)-6-(4-dimethylamino-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C30H28ClN7O	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0138070 Compound Info	(2R,3R,4S,5R)-2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol Show/Hide	C23H21FN4O3	1
1	IC50 = 134 nM Bioactivity Info	TI LI LO TS
CP0492876 Compound Info	5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-6-phenyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C28H23BrN6O	1
1	IC50 = 155 nM Bioactivity Info	TI LI LO TS
CP0402039 Compound Info	methyl 2-[4-amino-5-(3-bromophenyl)-7-thiophen-2-ylpyrido[2,3-d]pyrimidin-6-yl]acetate Show/Hide	C20H15BrN4O2S	1
1	IC50 = 163 nM Bioactivity Info	TI LI LO TS
CP0200853 Compound Info	5-(3-Bromo-phenyl)-7-(4-dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C21H18BrN5	1
1	IC50 = 167 nM Bioactivity Info	TI LI LO TS
CP0383205 Compound Info	5-(3-Bromo-phenyl)-6-(4-fluoro-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C28H22BrFN6O	1
1	IC50 = 197 nM Bioactivity Info	TI LI LO TS
CP0425859 Compound Info	7-(4-Dimethylamino-phenyl)-5,6-diphenyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C27H23N5	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0431457 Compound Info	5,6-Bis-(3-fluoro-4-methyl-phenyl)-7-thiophen-2-yl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C25H18F2N4S	1
1	IC50 = 288 nM Bioactivity Info	TI LI LO TS
CP0366798 Compound Info	7-(4-Dimethylamino-phenyl)-6-phenyl-pteridin-4-ylamine Show/Hide	C20H18N6	1
1	IC50 = 333 nM Bioactivity Info	TI LI LO TS
CP0480643 Compound Info	5-(3-Bromo-phenyl)-6-(3,4-dimethoxy-phenyl)-7-(4-dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C29H26BrN5O2	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0460157 Compound Info	5-(4-Bromo-thiophen-2-yl)-6-(3,4-dimethoxy-phenyl)-7-{4-[(2-methoxy-ethyl)-methyl-amino]-phenyl}-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C29H28BrN5O3S	1
1	IC50 = 367 nM Bioactivity Info	TI LI LO TS
CP0406658 Compound Info	6-Benzyl-5-(3-bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C29H25BrN6O	1
1	IC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0047724 Compound Info	7-(4-Dimethylamino-phenyl)-5-phenyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C21H19N5	1
1	IC50 = 467 nM Bioactivity Info	TI LI LO TS
CP0134601 Compound Info	5-Cyclohexyl-7-(4-dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C21H25N5	1
1	IC50 = 467 nM Bioactivity Info	TI LI LO TS
CP0166322 Compound Info	7-(4-Dimethylamino-phenyl)-6-p-tolyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C22H21N5	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0281006 Compound Info	7-(4-Dimethylamino-phenyl)-6-(4-methoxy-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C22H21N5O	1
1	IC50 = 567 nM Bioactivity Info	TI LI LO TS
CP0448113 Compound Info	5-(3-Bromo-phenyl)-7-(6-dimethylamino-pyridin-3-yl)-6-pentyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C25H27BrN6	1
1	IC50 = 625 nM Bioactivity Info	TI LI LO TS
CP0495479 Compound Info	5-(4-Bromo-thiophen-2-yl)-6-cyclopropyl-7-(6-dimethylamino-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C21H19BrN6S	1
1	IC50 = 625 nM Bioactivity Info	TI LI LO TS
CP0079164 Compound Info	3-[4-Amino-7-(4-dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-6-yl]-benzoic acid methyl ester Show/Hide	C23H21N5O2	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0276766 Compound Info	7-(4-Morpholin-4-yl-phenyl)-pteridin-4-ylamine Show/Hide	C16H16N6O	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0281868 Compound Info	7-(4-Dimethylamino-phenyl)-6-phenyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C21H19N5	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0076829 Compound Info	7-(4-Dimethylamino-phenyl)-pteridin-4-ylamine Show/Hide	C14H14N6	1
1	IC50 = 3600 nM Bioactivity Info	TI LI LO TS
CP0257633 Compound Info	(2R,3S,4R,5R)-2-Aminomethyl-5-(6-amino-purin-9-yl)-tetrahydro-furan-3,4-diol Show/Hide	C10H14N6O3	1
1	IC50 = 6330 nM Bioactivity Info	TI LI LO TS
CP0049447 Compound Info	7-(4-Dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C15H15N5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0078974 Compound Info	7-Phenyl-pteridin-4-ylamine Show/Hide	C12H9N5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0220501 Compound Info	7-(4-Methoxy-phenyl)-pteridin-4-ylamine Show/Hide	C13H11N5O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0252859 Compound Info	7-(4-Amino-phenyl)-pteridin-4-ylamine Show/Hide	C12H10N6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0366787 Compound Info	7-(4-Nitro-phenyl)-pteridin-4-ylamine Show/Hide	C12H8N6O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0382304 Compound Info	7-(4-Chloro-phenyl)-4-morpholin-4-yl-pteridine Show/Hide	C16H14ClN5O	1
1	IC50 = 22000 nM Bioactivity Info	TI LI LO TS
CP0179736 Compound Info	(2R,3R,4S,5R)-2-(6-Amino-5-nitro-pyrimidin-4-ylamino)-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C9H13N5O6	1
1	IC50 = 26000 nM Bioactivity Info	TI LI LO TS
CP0161822 Compound Info	6-(4-tert-Butyl-phenyl)-7-(4-dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C25H27N5	1
1	IC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0399477 Compound Info	7-(4-Dimethylamino-phenyl)-5,6-bis-(4-isopropyl-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C33H35N5	1
1	IC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0503565 Compound Info	5-(3-Bromo-phenyl)-6-isopropyl-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C25H25BrN6O	1
1	IC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0505927 Compound Info	5-(3-Bromo-phenyl)-6-cyclohexyl-7-(6-dimethylamino-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C26H27BrN6	1
1	IC50 > 1000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0071313 Compound Info	(2R,3R,4S,5R)-2-(2-amino-9-iodo-3,5,7-triazabicyclo[4.3.0]nona-1,3,5,8-tetraen-7-yl)-5-methyl-oxolane-3,4-diol Show/Hide	C11H13IN4O3	2
1	IC50 = 0.9 nM
2	IC50 = 9 nM
CP0103761 Compound Info	5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C22H19BrN6O	3
1	IC50 = 1.3 nM
2	IC50 = 1.7 nM
3	IC50 = 2 nM
CP0138070 Compound Info	(2R,3R,4S,5R)-2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol Show/Hide	C23H21FN4O3	2
1	IC50 = 1.5 nM
2	IC50 = 5 nM
CP0281006 Compound Info	7-(4-Dimethylamino-phenyl)-6-(4-methoxy-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C22H21N5O	1
1	IC50 = 92 nM
CP0257633 Compound Info	(2R,3S,4R,5R)-2-Aminomethyl-5-(6-amino-purin-9-yl)-tetrahydro-furan-3,4-diol Show/Hide	C10H14N6O3	1
1	IC50 = 170 nM
CP0281868 Compound Info	7-(4-Dimethylamino-phenyl)-6-phenyl-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C21H19N5	1
1	IC50 = 350 nM
CP0076829 Compound Info	7-(4-Dimethylamino-phenyl)-pteridin-4-ylamine Show/Hide	C14H14N6	1
1	IC50 = 440 nM
CP0049447 Compound Info	7-(4-Dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine Show/Hide	C15H15N5	1
1	IC50 = 773 nM
CP0179736 Compound Info	(2R,3R,4S,5R)-2-(6-Amino-5-nitro-pyrimidin-4-ylamino)-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C9H13N5O6	1
1	Ki = 300 nM

Clinical Information about the Protein

Target 1 ( Adenosine kinase (ADK) )

Target Type	Clinical trial Target
Disease	2 Target-related Diseases				2
1	Epilepsy [ICD-11: 8A60-8A68]
2	Pain [ICD-11: MG30-MG3Z]
Discontinued Drug(s)	3 Discontinued Drugs				3
1	A-134974	Drug Info	Terminated	Epilepsy
2	ABT-702	Drug Info	Terminated	Pain
3	GP-683	Drug Info	Terminated	Pain

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han