Brief Information of the Cell Line and Protein
Cell Line ID: CL000494 , THP1-Dual
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_X599
Protein ID: PT05581 , Cyclic GMP-AMP synthase
Gene Name CGAS
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID Q8N884
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000494  Protein ID: PT05581
 
Compound ID Compound Name Compound Formula
CP0549328
[2-[6,7-dichloro-9b-(4-chloro-2-formylanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
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C22H18Cl3N3O4
 1
1
IC50 = 1140 nM
   TI
   LI
   LO
   TS
CP0527944
2-amino-N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]acetamide
   Show/Hide
C19H20Cl2N6O2
 1
1
IC50 = 1380 nM
   TI
   LI
   LO
   TS
CP0564585
2-amino-1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]ethanone
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C17H17Cl2N5O
 1
1
IC50 = 1870 nM
   TI
   LI
   LO
   TS
CP0547099
1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
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C17H16Cl2N4O2
 1
1
IC50 = 2690 nM
   TI
   LI
   LO
   TS
CP0545588
[2-[6,7-dichloro-9b-[2-formyl-4-(trifluoromethyl)anilino]-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
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C23H18Cl2F3N3O4
 1
1
IC50 = 2720 nM
   TI
   LI
   LO
   TS
CP0573339
[2-[6,7-dichloro-9b-(3-chloro-2-formylanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
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C22H18Cl3N3O4
 1
1
IC50 = 2870 nM
   TI
   LI
   LO
   TS
CP0527948
1-[9b-[3,5-bis(trifluoromethyl)anilino]-6,7-dichloro-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
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C21H15Cl2F6N3O2
 1
1
IC50 = 3120 nM
   TI
   LI
   LO
   TS
CP0527945
[2-[9b-[3,5-bis(trifluoromethyl)anilino]-6,7-dichloro-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
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C23H17Cl2F6N3O3
 1
1
IC50 = 3230 nM
   TI
   LI
   LO
   TS
CP0947460
1-(6,7-Dichloro-9b-(1H-indol-3-yl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H19Cl2N3O2
 1
1
IC50 = 4070 nM
   TI
   LI
   LO
   TS
CP0955082
2-(6,7-Dichloro-9b-(1H-indol-3-yl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoethyl Acetate
   Show/Hide
C23H21Cl2N3O3
 1
1
IC50 = 5490 nM
   TI
   LI
   LO
   TS
CP0549843
1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-(methylamino)ethanone
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C18H19Cl2N5O
 1
1
IC50 = 6300 nM
   TI
   LI
   LO
   TS
CP0967557
2-(6,7-Dichloro-9b-(1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoethyl Acetate
   Show/Hide
C23H19Cl2N3O3
 1
1
IC50 = 6300 nM
   TI
   LI
   LO
   TS
CP0941170
(R)-N-(2-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2 yl)-2-oxoethyl)-4,4-difluoropyrrolidine-2-carboxamide
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C22H22Cl2F2N6O2
 1
1
IC50 = 6400 nM
   TI
   LI
   LO
   TS
CP0549330
1-[6,7-dichloro-9b-[4-(trifluoromethyl)anilino]-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
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C20H16Cl2F3N3O2
 1
1
IC50 = 6480 nM
   TI
   LI
   LO
   TS
CP0957294
1-(6,7-Dichloro-9b-(1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
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C21H17Cl2N3O2
 1
1
IC50 = 6950 nM
   TI
   LI
   LO
   TS
CP0555277
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2-(furan-2-yl)acetamide
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C23H21Cl2N5O3
 1
1
IC50 = 7170 nM
   TI
   LI
   LO
   TS
CP0573549
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2-piperazin-1-ylacetamide
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C23H27Cl2N7O2
 1
1
IC50 = 7860 nM
   TI
   LI
   LO
   TS
CP0578365
tert-butyl N-[1-[[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]amino]-2-methyl-1-oxopropan-2-yl]carbamate
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C26H32Cl2N6O4
 1
1
IC50 = 8210 nM
   TI
   LI
   LO
   TS
CP0954216
1-(6,7-Dichloro-9b-(6-chloro-1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3 b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H16Cl3N3O2
 1
1
IC50 = 8590 nM
   TI
   LI
   LO
   TS
CP0573341
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2-(5-methyl-1,2-oxazol-3-yl)acetamide
   Show/Hide
C23H22Cl2N6O3
 1
1
IC50 = 9450 nM
   TI
   LI
   LO
   TS
CP0577817
[2-[6,7-dichloro-9b-(2-formylanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
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C22H19Cl2N3O4
 1
1
IC50 = 9590 nM
   TI
   LI
   LO
   TS
CP0564586
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
   Show/Hide
C27H20Cl2F3N7O3
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0953225
(S)-2-Amino-N-(2-(6,7-dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoethyl)-3-(1H-pyrazol-3-yl)propanamide
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C23H24Cl2N8O2
 1
1
IC50 = 10200 nM
   TI
   LI
   LO
   TS
CP0540310
2-amino-N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2-methylpropanamide
   Show/Hide
C21H24Cl2N6O2
 1
1
IC50 = 10500 nM
   TI
   LI
   LO
   TS
CP0967965
(S)-2-amino-N-(2-(6,7-dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-oxoethyl)-2-hydroxyacetamide
   Show/Hide
C19H20Cl2N6O3
 1
1
IC50 = 11000 nM
   TI
   LI
   LO
   TS
CP0969739
1-(6,7-Dichloro 9b-(6-methoxy-1H-indol 3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3 b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C22H19Cl2N3O3
 1
1
IC50 = 11300 nM
   TI
   LI
   LO
   TS
CP0969860
1-(6,7-Dichloro-9b-(4,6-difluoro-1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H15Cl2F2N3O2
 1
1
IC50 = 12900 nM
   TI
   LI
   LO
   TS
CP0549327
1-amino-N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]cyclopropane-1-carboxamide
   Show/Hide
C21H22Cl2N6O2
 1
1
IC50 = 13500 nM
   TI
   LI
   LO
   TS
CP0941171
1-(6,7-Dichloro-9b-(6-fluoro-1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3 b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H16Cl2FN3O2
 1
1
IC50 = 14100 nM
   TI
   LI
   LO
   TS
CP0564583
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2,2-difluoro-2-(4-methylphenoxy)acetamide
   Show/Hide
C26H23Cl2F2N5O3
 1
1
IC50 = 15500 nM
   TI
   LI
   LO
   TS
CP0579667
1,1,1,3,3,3-hexafluoropropan-2-yl 6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carboxylate
   Show/Hide
C19H14Cl2F6N4O2
 1
1
IC50 = 19200 nM
   TI
   LI
   LO
   TS
CP0542853
[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-[3-(difluoromethoxy)cyclobutyl]methanone
   Show/Hide
C21H20Cl2F2N4O2
 1
1
IC50 = 20300 nM
   TI
   LI
   LO
   TS
CP0578363
1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-(dimethylamino)ethanone
   Show/Hide
C19H21Cl2N5O
 1
1
IC50 = 21000 nM
   TI
   LI
   LO
   TS
CP0967964
(S)-6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-2-prolyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
   Show/Hide
C20H21Cl2N5O
 1
1
IC50 = 22200 nM
   TI
   LI
   LO
   TS
CP0953224
3-(1-(6,7-dichloro-1H-benzo[d]imidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)isobenzofuran-1(3H)-one
   Show/Hide
C19H12Cl2N4O3
 1
1
IC50 = 32900 nM
   TI
   LI
   LO
   TS
CP0545587
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]acetamide
   Show/Hide
C19H19Cl2N5O2
 1
1
IC50 = 37700 nM
   TI
   LI
   LO
   TS
CP0527947
2-hydroxy-1-[(1R,9S,13R,14R)-5,6,17-trichloro-22-oxa-8,11,21-triazahexacyclo[12.7.1.01,9.02,7.09,13.015,20]docosa-2(7),3,5,15(20),16,18-hexaen-11-yl]ethanone
   Show/Hide
C20H16Cl3N3O3
 1
1
IC50 = 38200 nM
   TI
   LI
   LO
   TS
CP0552809
ethyl 4-[[6,7-dichloro-2-(2-hydroxyacetyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-9b-yl]amino]benzoate
   Show/Hide
C22H21Cl2N3O4
 1
1
IC50 = 39400 nM
   TI
   LI
   LO
   TS
CP0527943
1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-morpholin-4-ylethanone
   Show/Hide
C21H23Cl2N5O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0547098
[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-(3-hydroxycyclobutyl)methanone
   Show/Hide
C20H20Cl2N4O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0554221
1-[(1R,9S,13R,14R)-5,6-dichloro-22-oxa-8,11,21-triazahexacyclo[12.7.1.01,9.02,7.09,13.015,20]docosa-2(7),3,5,15,17,19-hexaen-11-yl]-2-hydroxyethanone
   Show/Hide
C20H17Cl2N3O3
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0564584
1-[6,7-dichloro-9b-(2-methoxyanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
   Show/Hide
C20H19Cl2N3O3
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0573340
1-[6,7-dichloro-9b-(3,5-difluoroanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
   Show/Hide
C19H15Cl2F2N3O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0573554
1-(6,7,9b-trichloro-3,5-dihydro-1H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethanone
   Show/Hide
C13H11Cl3N2O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0577822
1-(5,6-dichloro-11,14-dimethoxy-8,16,18-triazapentacyclo[7.7.4.01,9.02,7.010,15]icosa-2(7),3,5,10,12,14-hexaen-18-yl)-2-hydroxyethanone
   Show/Hide
C21H21Cl2N3O4
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0578362
(3-aminooxetan-3-yl)-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]methanone
   Show/Hide
C19H19Cl2N5O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0955863
(3S,4R,5S)-N-(2-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoethyl)-3,4,5-trihydroxycyclohex-1-ene-1-carboxamide
   Show/Hide
C24H25Cl2N5O5
 1
1
IC50 > 50000 nM
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   LI
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   TS