Brief Information of the Cell Line and Protein
Cell Line ID: CL000937 , R2/PCFT4
Category Transformed cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_C5SG
Protein ID: PT05580 , Proton-coupled folate transporter
Gene Name SLC46A1
Organism Homo sapiens, Human
Protein Classification Transporter
Uniprot ID Q96NT5
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000937  Protein ID: PT05580
 
Compound ID Compound Name Compound Formula
CP0055020
AGF94
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C19H21N5O6S
 2
1
IC50 = 3.34 nM
   TI
   LI
   LO
   TS
2
Ki = 330 nM
   TI
   LI
   LO
   TS
CP0374708
(2S)-2-[[4-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
 1
1
IC50 = 5.39 nM
   TI
   LI
   LO
   TS
CP0206826
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-3-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
 1
1
IC50 = 6.51 nM
   TI
   LI
   LO
   TS
CP0036368
(2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid
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C20H21N5O6
 3
1
IC50 = 13.2 nM
   TI
   LI
   LO
   TS
2
Ki = 94 nM
   TI
   LI
   LO
   TS
3
Ki = 259 nM
   TI
   LI
   LO
   TS
CP0330758
(S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-butyl]-thiophene-2-carbonyl}-amino)-pentanedioicAcid
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C20H23N5O6S
 1
1
IC50 = 43.4 nM
   TI
   LI
   LO
   TS
CP0946262
(S)-2-(4-{[N-Methyl-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)methylamino]-carbonyl}phenylcarbonyl)aminopentanedioic acid
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C21H22N6O7
 1
1
IC50 = 48.6 nM
   TI
   LI
   LO
   TS
CP0383886
CHEBI:71223
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C23H23N7O5
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0399631
(2S)-2-[[5-[5-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C21H25N5O6S
 1
1
IC50 = 57.4 nM
   TI
   LI
   LO
   TS
CP0874529
{4-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethoxy]benzoyl}-L-glutamic Acid
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C20H21N5O7
 2
1
IC50 = 57.5 nM
   TI
   LI
   LO
   TS
2
Ki = 640 nM
   TI
   LI
   LO
   TS
CP0383884
(2S)-2-[[5-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]pyridine-2-carbonyl]amino]pentanedioic acid
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C21H24N6O6
 2
1
IC50 = 57.6 nM
   TI
   LI
   LO
   TS
2
Ki = 332 nM
   TI
   LI
   LO
   TS
CP0468983
(2S)-2-[[5-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C18H19N5O6S
 1
1
IC50 = 80.2 nM
   TI
   LI
   LO
   TS
CP0740290
(4-{N-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]acetamido}benzoyl)-L-glutamic Acid
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C22H24N6O7
 2
1
IC50 = 81.7 nM
   TI
   LI
   LO
   TS
2
Ki = 1680 nM
   TI
   LI
   LO
   TS
CP0838078
(4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic Acid
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C20H22N6O6
 2
1
IC50 = 87.4 nM
   TI
   LI
   LO
   TS
2
Ki = 850 nM
   TI
   LI
   LO
   TS
CP0705782
(4-{N-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]formamido}benzoyl)-L-L-glutamic Acid
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C21H22N6O7
 2
1
IC50 = 88.5 nM
   TI
   LI
   LO
   TS
2
Ki = 730 nM
   TI
   LI
   LO
   TS
CP0041026
(2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid
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C21H22N4O6S
 1
1
IC50 = 99.5 nM
   TI
   LI
   LO
   TS
CP0705783
(4-{N-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]-2,2,2-trifluoroacetamido}benzoyl)-L-glutamic Acid
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C22H21F3N6O7
 2
1
IC50 = 109 nM
   TI
   LI
   LO
   TS
2
Ki = 800 nM
   TI
   LI
   LO
   TS
CP0036197
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
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C20H22N8O5
 2
1
IC50 = 120.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 121 nM
   TI
   LI
   LO
   TS
CP0381988
(2S)-2-[[5-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)butyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C20H23N5O6S
 1
1
IC50 = 141 nM
   TI
   LI
   LO
   TS
CP0050307
(S)-2-(4-(4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl)benzamido)pentanedioic acid
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C22H25N5O6
 2
1
IC50 = 213 nM
   TI
   LI
   LO
   TS
2
Ki = 460 nM
   TI
   LI
   LO
   TS
CP0776522
(4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]thio}benzoyl)-L-glutamic Acid
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C20H21N5O6S
 2
1
IC50 = 267 nM
   TI
   LI
   LO
   TS
2
Ki = 1480 nM
   TI
   LI
   LO
   TS
CP0461015
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)propyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
 1
1
IC50 = 312 nM
   TI
   LI
   LO
   TS
CP0946260
(S)-2-(3-{[N-methyl-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)methylamino]-carbonyl}phenylcarbonyl)aminopentanedioic acid
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C21H22N6O7
 1
1
IC50 = 747 nM
   TI
   LI
   LO
   TS
CP0379858
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]pentanoic acid
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C19H23N5O4S
 2
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
2
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0386883
4-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]butanoic acid
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C18H21N5O4S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0386884
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]hexanedioic acid
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C20H23N5O6S
 2
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
2
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0411313
5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carboxylic acid
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C14H14N4O3S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0419800
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]butanedioic acid
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C18H19N5O6S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0200251
(2S)-2-[[5-[(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)methyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C17H17N5O6S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0399627
(2S)-2-[[5-[6-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)hexyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C22H27N5O6S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0374709
(2S)-2-[[4-[3-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)propyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0374710
(2S)-2-[[5-[3-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)propyl]thiophene-3-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0383883
(2S)-2-[[6-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]pyridine-3-carbonyl]amino]pentanedioic acid
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C21H24N6O6
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0383885
(2S)-2-[[6-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)but-1-ynyl]pyridine-3-carbonyl]amino]pentanedioic acid
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C21H20N6O6
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0383887
(2S)-2-[[6-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]pyridine-2-carbonyl]amino]pentanedioic acid
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C21H24N6O6
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0416461
(2S)-2-[[6-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)but-1-ynyl]pyridine-2-carbonyl]amino]pentanedioic acid
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C21H20N6O6
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0429653
(2S)-2-[[5-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)but-1-ynyl]pyridine-2-carbonyl]amino]pentanedioic acid
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C21H20N6O6
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0876574
(S)-2-(5-{[N-methyl-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)methylamino]carbonyl}thiophene-3-carbonyl)aminopentanedioic acid
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C19H20N6O7S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0931090
(S)-2-(5-{[N-methyl-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)methylamino]carbonyl}thiophene-2-carbonyl)aminopentanedioic acid
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C19H20N6O7S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0935714
(S)-2-(4-{[N-methyl-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)methylamino]carbonyl}thiophene-2-carbonyl)aminopentanedioic acid
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C19H20N6O7S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0946261
(S)-2-(4-{[N-methyl-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)methylamino]-sulfonyl}phenylcarbonyl)aminopentanedioic acid
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C20H22N6O8S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0083588
(S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl)benzamido)pentanedioic acid
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C21H23N5O6
 1
1
Ki = 220 nM
   TI
   LI
   LO
   TS