| Compound ID |
Compound Name |
Compound Formula |
|
CP0137054
|
4-[1-(3-chloro-2-methylindazol-5-yl)-5-methyl-4-[(3R)-3-(methylamino)piperidine-1-carbonyl]imidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C26H25ClFN7O
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0176281
|
4-[4-[(3R)-3-aminopiperidine-1-carbonyl]-1-(3-chloro-2-methylindazol-5-yl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C25H23ClFN7O
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0238212
|
4-[1-(3-chloro-2-methylindazol-5-yl)-5-methyl-4-[(3S)-3-(methylamino)pyrrolidine-1-carbonyl]imidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C25H23ClFN7O
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0125130
|
2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)-5-methyl-N-[(3R)-piperidin-3-yl]imidazole-4-carboxamide
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0361713
|
4-[4-[(3R)-3-aminopiperidine-1-carbonyl]-1-(4-methoxyphenyl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C24H24FN5O2
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0268631
|
4-[4-[(3S)-3-aminopyrrolidine-1-carbonyl]-5-methyl-1-(2-methylindazol-5-yl)imidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C24H22FN7O
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0137061
|
4-[4-[(3R)-3-aminopiperidine-1-carbonyl]-5-methyl-1-(1-methylindazol-5-yl)imidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C25H24FN7O
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0349899
|
4-[4-[(3S)-3-aminopyrrolidine-1-carbonyl]-1-(3-fluoro-4-methoxyphenyl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
EC50 = 34 nM
|
|
|
|
CP0125134
|
4-[4-[(3S)-3-(dimethylamino)pyrrolidine-1-carbonyl]-5-methyl-1-(2-methylindazol-5-yl)imidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C26H26FN7O
|
1
|
| 1 |
EC50 = 43 nM
|
|
|
|
CP0176284
|
4-[4-[(3S)-3-(dimethylamino)pyrrolidine-1-carbonyl]-1-(7-fluoro-2-methylindazol-5-yl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C26H25F2N7O
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0125133
|
4-[4-[(3R)-3-aminopiperidine-1-carbonyl]-5-methyl-1-(2-methylindazol-5-yl)imidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C25H24FN7O
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0326882
|
4-[4-[(3S)-3-(dimethylamino)pyrrolidine-1-carbonyl]-1-(6-fluoro-2-methylindazol-5-yl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C26H25F2N7O
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0125129
|
4-[4-[(3R)-3-aminopiperidine-1-carbonyl]-5-methyl-1-(4-methylphenyl)imidazol-2-yl]benzonitrile
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0125135
|
2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)-5-methyl-N-[(3S)-piperidin-3-yl]imidazole-4-carboxamide
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0031502
|
4-[2-(4-methylphenyl)-5-[[(3R)-pyrrolidin-3-yl]methoxy]pyridin-3-yl]benzonitrile
Show/Hide
|
C24H23N3O
|
1
|
| 1 |
EC50 = 62 nM
|
|
|
|
CP0158470
|
4-[4-[(3R)-3-aminopiperidine-1-carbonyl]-1-(3-fluoro-4-methoxyphenyl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0155012
|
2-fluoro-4-[1-(6-fluoro-2-methylindazol-5-yl)-5-methyl-4-[(3S)-3-(methylamino)pyrrolidine-1-carbonyl]imidazol-2-yl]benzonitrile
Show/Hide
|
C25H23F2N7O
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0268628
|
4-[4-[(3S)-3-aminopiperidine-1-carbonyl]-1-(3-fluoro-4-methoxyphenyl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
EC50 = 92 nM
|
|
|
|
CP0323785
|
4-[4-[3-(aminomethyl)azetidine-1-carbonyl]-1-(3-fluoro-4-methoxyphenyl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0125131
|
2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)-5-methyl-N-piperidin-4-ylimidazole-4-carboxamide
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0238209
|
4-[4-[(3R)-3-aminopiperidine-1-carbonyl]-1-(6-cyclopropylpyridin-3-yl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C25H25FN6O
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0238214
|
2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)-5-methyl-N-[(3R)-pyrrolidin-3-yl]imidazole-4-carboxamide
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0361712
|
4-[4-[(3R)-3-aminopyrrolidine-1-carbonyl]-1-(3-fluoro-4-methoxyphenyl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0268633
|
4-[4-[(3R)-3-aminopiperidine-1-carbonyl]-1-(6-methoxypyridin-3-yl)-5-methylimidazol-2-yl]-2-fluorobenzonitrile
Show/Hide
|
C23H23FN6O2
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0238210
|
2-(4-cyano-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)-5-methyl-N-[(3S)-pyrrolidin-3-yl]imidazole-4-carboxamide
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0838514
|
PULRODEMSTAT BESILATE
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|
C30H29F2N5O5S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0550515
|
4-[2-(4-amino-piperidin-1-yl)-5-(4- methoxyphenyl)-1-methyl-6-oxo- 1,6-dihydropyrimidin-4-yl]- benzonitrile
Show/Hide
|
C24H24FN5O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0568405
|
4-[2-(4-amino-piperidin-1-yl)-5- (4-methoxyphenyl)-1-methyl-6-oxo- 1,6-dihydro-pyrimidin-4-yl]- benzonitrile
Show/Hide
|
C24H25N5O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0568406
|
4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-tolyl-1,6- dihydropyrimidin-4-yl)-benzonitrile
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0553766
|
4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p-tolyl-4,5- dihydro-pyrazin-2-yl]-2-fluoro- benzonitrile
Show/Hide
|
C24H24FN5O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0361693
|
4-[5-(4-methylphenyl)-2-[[(3R)-pyrrolidin-3-yl]methyl]pyrimidin-4-yl]benzonitrile
Show/Hide
|
C23H22N4
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0574192
|
4-[2-(4-aminopiperidin-1-yl)-5-(4- methylphenyl)pyrimidin-4- yl]benzonitrile
Show/Hide
|
C23H23N5
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0551796
|
4-[6-(4-aminopiperidin-1-yl)-4- methyl-3-(4-methylphenyl)-5-oxo- 4, 5-dihydropyrazin-2- yl]benzonitrile
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0557131
|
4-[2-[(3aR,7aS)-1,2,3,3a,4,6,7,7a-octahydropyrrolo[3,2-c]pyridin-5-yl]-5-(4-methylphenyl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C25H25N5
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0219218
|
4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p-tolyl-4,5- dihydro-pyrazin-2-yl]-3-fluoro- benzonitrile
Show/Hide
|
C24H24FN5O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
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CP0476611
|
4-[3-[(3R)-3-aminopiperidine-1-carbonyl]-5-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]pyrazol-1-yl]benzonitrile
Show/Hide
|
C20H21N7O3
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
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CP0539001
|
4-[3-[(3R)-3-aminopiperidine-1-carbonyl]-5-(3,3,3-trifluoro-2-hydroxypropoxy)pyrazol-1-yl]benzonitrile
Show/Hide
|
C19H20F3N5O3
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
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CP0408843
|
4-[3-[(3R)-3-aminopiperidine-1-carbonyl]-5-[(3-ethyl-1,2-oxazol-5-yl)methoxy]pyrazol-1-yl]benzonitrile
Show/Hide
|
C22H24N6O3
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
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CP0487806
|
4-[3-[(3R)-3-aminopiperidine-1-carbonyl]-5-[(3-methyl-1,2-oxazol-5-yl)methoxy]pyrazol-1-yl]benzonitrile
Show/Hide
|
C21H22N6O3
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
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CP0534491
|
4-{3-[((3R)-3- aminopiperidyl)carbonyl]-5-(2- pyridylmethoxy)pyrazolyl} benzenecarbonitrile
Show/Hide
|
C22H22N6O2
|
1
|
| 1 |
IC50 = 2300 nM
|
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|
