Brief Information of the Cell Line and Protein
Cell Line ID: CL000633 , TM3
Synonyms
TM-3
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_4326
Protein ID: PT02397 , Protein smoothened
Gene Name SMO
Organism Mus musculus, Mouse
Protein Classification Membrane receptor
Uniprot ID P56726
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000633  Protein ID: PT02397
 
Compound ID Compound Name Compound Formula
CP0392338
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-[(2R)-2-methylmorpholin-4-yl]isoquinolin-1-amine
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C29H26ClN5O
 2
1
IC50 = 0.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.6 nM
   TI
   LI
   LO
   TS
CP0449700
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]isoquinolin-1-amine
   Show/Hide
C30H28ClN5O
 2
1
IC50 = 0.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0486918
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-morpholin-4-ylisoquinolin-1-amine
   Show/Hide
C28H24ClN5O
 2
1
IC50 = 0.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 2.6 nM
   TI
   LI
   LO
   TS
CP0392333
N-[4-methyl-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-4-morpholin-4-ylbenzamide
   Show/Hide
C27H26N4O2
 1
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0392341
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-1,6-naphthyridin-5-amine
   Show/Hide
C29H27ClN6O
 2
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0449699
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]quinolin-5-amine
   Show/Hide
C30H28ClN5O
 2
1
IC50 = 0.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0507774
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-7-[(2R,6S)-2,6-dimethylmorpholin-4-yl]quinolin-4-amine
   Show/Hide
C30H28ClN5O
 2
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0392339
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-piperidin-1-ylisoquinolin-1-amine
   Show/Hide
C29H26ClN5
 2
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0392340
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R)-2-methylmorpholin-4-yl]-1,6-naphthyridin-5-amine
   Show/Hide
C28H25ClN6O
 2
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0544458
3,5-dimethoxy-N-[4-methyl-3-(5-phenyl-1H-imidazol-2-yl)phenyl]benzamide
   Show/Hide
C25H23N3O3
 1
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
CP0455389
1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}1-methylethylamine
   Show/Hide
C27H30N6
 2
1
IC50 = 1.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0449701
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-(1,1-dioxo-1,4-thiazinan-4-yl)isoquinolin-1-amine
   Show/Hide
C28H24ClN5O2S
 2
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
2
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0472123
2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propan-2-ol
   Show/Hide
C27H29N5O
 2
1
IC50 = 2.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0375008
N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
   Show/Hide
C24H23ClN4O3
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0486916
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]quinoxalin-5-amine
   Show/Hide
C29H27ClN6O
 2
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0374378
1-[6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl]-N,N-dimethylmethanamine
   Show/Hide
C27H30N6
 2
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
2
IC50 = 246 nM
   TI
   LI
   LO
   TS
CP0452552
(+/-)-2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propane-1,2-diol
   Show/Hide
C27H29N5O2
 2
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
2
IC50 = 136 nM
   TI
   LI
   LO
   TS
CP0486917
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]isoquinolin-1-amine
   Show/Hide
C24H17ClN4
 2
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
2
IC50 = 157 nM
   TI
   LI
   LO
   TS
CP0457490
6-{4-[4-(4-Cyanobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C26H21N7
 2
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 256 nM
   TI
   LI
   LO
   TS
CP0455398
6-[(S)-4-(4-Benzylphthalazin-1-yl)-3-methylpiperazin-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
2
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0498345
6-[(R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
2
IC50 = 244 nM
   TI
   LI
   LO
   TS
CP0452554
N-[[6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl]methyl]acetamide
   Show/Hide
C27H28N6O
 2
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
2
IC50 = 327 nM
   TI
   LI
   LO
   TS
CP0397016
1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}ethanol
   Show/Hide
C26H27N5O
 2
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
2
IC50 = 222 nM
   TI
   LI
   LO
   TS
CP0497373
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicotinamide
   Show/Hide
C25H24N6O
 2
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
2
IC50 = 149 nM
   TI
   LI
   LO
   TS
CP0502393
6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C25H21ClN6
 2
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
2
IC50 = 498 nM
   TI
   LI
   LO
   TS
CP0497372
1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}cyclopropanol
   Show/Hide
C27H27N5O
 2
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
2
IC50 = 345 nM
   TI
   LI
   LO
   TS
CP0457488
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicotinonitrile
   Show/Hide
C25H22N6
 2
1
IC50 = 69 nM
   TI
   LI
   LO
   TS
2
IC50 = 821 nM
   TI
   LI
   LO
   TS
CP0422210
6-[(S)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
2
IC50 = 735 nM
   TI
   LI
   LO
   TS
CP0387837
6-[(R)-4-(4-Benzylphthalazin-1-yl)-3-methylpiperazin-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 86 nM
   TI
   LI
   LO
   TS
2
IC50 = 738 nM
   TI
   LI
   LO
   TS
CP0457489
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridine-3-sulfonicAcid Amide
   Show/Hide
C24H24N6O2S
 2
1
IC50 = 104 nM
   TI
   LI
   LO
   TS
2
IC50 = 919 nM
   TI
   LI
   LO
   TS
CP0422211
6-{4-[4-(4-Fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C25H21FN6
 2
1
IC50 = 112 nM
   TI
   LI
   LO
   TS
2
IC50 = 975 nM
   TI
   LI
   LO
   TS
CP0452558
6-{4-[4-(3-Chlorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C25H21ClN6
 2
1
IC50 = 112 nM
   TI
   LI
   LO
   TS
2
IC50 = 693 nM
   TI
   LI
   LO
   TS
CP0387836
1-Benzyl-4-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]phthalazine
   Show/Hide
C25H22F3N5
 2
1
IC50 = 134 nM
   TI
   LI
   LO
   TS
2
IC50 = 1327 nM
   TI
   LI
   LO
   TS
CP0474046
6-[4-(4-Benzylphthalazin-1-yl)[1,4]diazepan-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
2
IC50 = 1632 nM
   TI
   LI
   LO
   TS
CP0374376
7-Benzyl-4-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]furo[2,3-d]pyridazine
   Show/Hide
C23H20F3N5O
 2
1
IC50 = 212 nM
   TI
   LI
   LO
   TS
2
IC50 = 2560 nM
   TI
   LI
   LO
   TS
CP0452555
1-Benzyl-4-(4-pyridin-2-yl-piperazin-1-yl)phthalazine
   Show/Hide
C24H23N5
 2
1
IC50 = 258 nM
   TI
   LI
   LO
   TS
2
IC50 = 772 nM
   TI
   LI
   LO
   TS
CP0407677
4-{4-[4-(5-Cyanopyridin-2-yl)piperazin-1-yl]phthalazin-1-ylmethyl}benzoic Acid Methyl Ester
   Show/Hide
C27H24N6O2
 2
1
IC50 = 265 nM
   TI
   LI
   LO
   TS
2
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0374377
6-{4-[4-(4-Trifluoromethylbenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C26H21F3N6
 2
1
IC50 = 366 nM
   TI
   LI
   LO
   TS
2
IC50 = 1239 nM
   TI
   LI
   LO
   TS
CP0457491
[6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl]methanol
   Show/Hide
C25H25N5O
 2
1
IC50 = 374 nM
   TI
   LI
   LO
   TS
2
IC50 = 2448 nM
   TI
   LI
   LO
   TS
CP0498346
4-(1-Benzyl-1H-indol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carbonitrile
   Show/Hide
C26H24N4
 2
1
IC50 = 382 nM
   TI
   LI
   LO
   TS
2
IC50 = 1507 nM
   TI
   LI
   LO
   TS
CP0428583
1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine
   Show/Hide
C25H24N4
 2
1
IC50 = 414 nM
   TI
   LI
   LO
   TS
2
IC50 = 2246 nM
   TI
   LI
   LO
   TS
CP0428584
1-Pyridin-4-ylmethyl-4-(4-pyridin-2-ylpiperazin-1-yl)phthalazine
   Show/Hide
C23H22N6
 2
1
IC50 = 690 nM
   TI
   LI
   LO
   TS
2
IC50 = 4493 nM
   TI
   LI
   LO
   TS
CP0397039
7-Benzyl-4-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1Himidazo[4,5-d]pyridazine
   Show/Hide
C22H20F3N7
 2
1
IC50 = 724 nM
   TI
   LI
   LO
   TS
2
IC50 = 1549 nM
   TI
   LI
   LO
   TS
CP0455276
6-[4-(1-Benzylisoquinolin-4-yl)piperazin-1-yl]nicotinonitrile
   Show/Hide
C26H23N5
 2
1
IC50 = 910 nM
   TI
   LI
   LO
   TS
2
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0431427
6-[4-(4-Benzylisoquinolin-1-yl)piperazin-1-yl]nicotinonitrile
   Show/Hide
C26H23N5
 2
1
IC50 = 1427 nM
   TI
   LI
   LO
   TS
2
IC50 = 2987 nM
   TI
   LI
   LO
   TS
CP0387801
4-Benzyl-7-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]furo[2,3-d]pyridazine
   Show/Hide
C23H20F3N5O
 2
1
IC50 = 1798 nM
   TI
   LI
   LO
   TS
2
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0387803
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicotinic Acid
   Show/Hide
C25H23N5O2
 2
1
IC50 = 2665 nM
   TI
   LI
   LO
   TS
2
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0397036
4-[1-(4-Benzylphthalazin-1-yl)piperidin-4-yl]benzonitrile
   Show/Hide
C27H24N4
 2
1
IC50 = 3776 nM
   TI
   LI
   LO
   TS
2
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0387805
4-{4-[4-(5-Cyanopyridin-2-yl)piperazin-1-yl]phthalazin-1-ylmethyl}benzoic Acid
   Show/Hide
C26H22N6O2
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS