Brief Information of the Cell Line and Protein
Cell Line ID: CL000064 , Chem-1
Synonyms
ChemiSCREEN Chem-1
Wild-type control Chem-1 cell line
ChemiSCREEN Chem-1 parental cell line
Category Undefined cell line type
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_L474
Protein ID: PT01823 , Prostaglandin F2-alpha receptor
Gene Name PTGFR
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P43088
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000064  Protein ID: PT01823
 
Compound ID Compound Name Compound Formula
CP0847317
2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid
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C22H25NO6S
 1
1
EC50 = 32 nM
   TI
   LI
   LO
   TS
CP0055947
(15S)-prostaglandin E2
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C20H32O5
 1
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
CP0862926
2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-4-phenoxy-1-buten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid
   Show/Hide
C22H25NO5S
 1
1
EC50 = 380 nM
   TI
   LI
   LO
   TS
CP0847322
2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-5-phenoxy-1-penten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid
   Show/Hide
C23H27NO5S
 1
1
EC50 = 8500 nM
   TI
   LI
   LO
   TS
CP0391092
2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-oxazole-4-carboxylic acid
   Show/Hide
C20H22ClNO6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0391098
4-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]thiophene-2-carboxylic acid
   Show/Hide
C21H23ClO5S
 1
1
EC50 > 10000 nM
   TI
   LI
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   TS
CP0401698
2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-methoxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C21H24ClNO5S
 1
1
EC50 > 10000 nM
   TI
   LI
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   TS
CP0401699
2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C20H22ClNO5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0401700
2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C20H22ClNO5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0401702
2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-fluoro-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C20H21ClFNO4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0407410
4-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]furan-2-carboxylic acid
   Show/Hide
C21H23ClO6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0434444
5-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]furan-2-carboxylic acid
   Show/Hide
C21H23ClO6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0380278
2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-(phenoxymethyl)-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid
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C19H21NO5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0847318
2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-3-phenoxy-1-propen-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid
   Show/Hide
C21H23NO5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0847320
2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(2-phenoxyethyl)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C20H23NO5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0870958
2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(3-phenoxypropyl)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C21H25NO5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0573893
6-bromo-N-[2-fluoro-4-(2H-tetrazol-5-yl)phenyl]-3-methyl-2-phenylquinoline-4-carboxamide
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C24H16BrFN6O
 1
1
IC50 = 5.2 nM
   TI
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   TS
CP0566005
3-Fluoro-4-{[(6-iodo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}benzoic acid
   Show/Hide
C24H16FIN2O3
 1
1
IC50 = 6 nM
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CP0515075
US11149018, Example 276
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C26H27BrClN3O3
 1
1
IC50 = 7.2 nM
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CP0272414
US11149018, Example 34
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C26H27BrClN3O3
 1
1
IC50 = 11 nM
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CP0537756
4-[(7-bromo-2-methyl-3-phenylnaphthalene-1-carbonyl)amino]-3-fluorobenzoic acid
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C25H17BrFNO3
 1
1
IC50 = 13 nM
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CP0566006
4-{[(6-Bromo-3-chloro-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid
   Show/Hide
C23H13BrClFN2O3
 1
1
IC50 = 17 nM
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   TS
CP0578279
4-[(6-bromo-3-methyl-2-phenylquinolin-4-yl)methylamino]-3-fluorobenzoic acid
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C24H18BrFN2O2
 1
1
IC50 = 25 nM
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   TS
CP0548134
4-{[(6-Bromo-3-cyclopropyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid
   Show/Hide
C26H18BrFN2O3
 1
1
IC50 = 27 nM
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   LI
   LO
   TS
CP0565043
4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid
   Show/Hide
C24H16BrFN2O3
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0568628
4-[(6-bromo-3-methyl-1-oxo-2-phenylisoquinoline-4-carbonyl)amino]-3-fluorobenzoic acid
   Show/Hide
C24H16BrFN2O4
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0572524
4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid
   Show/Hide
C26H25BrN2O3
 1
1
IC50 = 68 nM
   TI
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   TS
CP0571433
3-Fluoro-4-({[3-methyl-2-phenyl-6-(trifluoromethyl)quinolin-4-yl]carbonyl}amino)benzoic acid
   Show/Hide
C25H16F4N2O3
 1
1
IC50 = 93 nM
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CP0548202
6-Bromo-N-(4-carbamoyl-2-fluorophenyl)-3-methyl-2-phenylquinoline-4-carboxamide
   Show/Hide
C24H17BrFN3O2
 1
1
IC50 = 100 nM
   TI
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   TS
CP0537758
(+/−)-5-({[6-Bromo-2-(3,3-difluoroazetidin-1-yl)-3-methylquinolin-4-yl]carbonyl}amino)-4-(2-chlorophenyl)pentanoic acid (Racemate)
   Show/Hide
C25H23BrClF2N3O3
 1
1
IC50 = 120 nM
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   TS
CP0539216
4-{[(6-Bromo-3-methyl-1-oxido-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid
   Show/Hide
C24H16BrFN2O4
 1
1
IC50 = 120 nM
   TI
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   TS
CP0558306
4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid
   Show/Hide
C28H25FN2O3
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0568627
4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}benzoic acid
   Show/Hide
C24H17BrN2O3
 1
1
IC50 = 150 nM
   TI
   LI
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   TS
CP0537754
6-bromo-3-methyl-2-phenyl-N-(2-pyridin-2-ylpropyl)quinoline-4-carboxamide
   Show/Hide
C25H22BrN3O
 1
1
IC50 = 190 nM
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   TS
CP0545859
4-[(6-bromo-3-methyl-2-phenylquinoline-4-carbonyl)amino]-3-(3-methoxyphenyl)butanoic acid
   Show/Hide
C28H25BrN2O4
 1
1
IC50 = 190 nM
   TI
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   TS
CP0548201
4-{[(6-Chloro-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid
   Show/Hide
C24H16ClFN2O3
 1
1
IC50 = 200 nM
   TI
   LI
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   TS
CP0558304
6-bromo-3-methyl-2-phenyl-N-(2-pyridin-2-ylethyl)quinoline-4-carboxamide
   Show/Hide
C24H20BrN3O
 1
1
IC50 = 200 nM
   TI
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   TS
CP0558305
4-[(6-bromo-3-methyl-2-phenylquinolin-4-yl)methoxy]-3-fluorobenzoic acid
   Show/Hide
C24H17BrFNO3
 1
1
IC50 = 250 nM
   TI
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CP0537755
6-bromo-3-methyl-2-phenyl-N-(1-pyridin-2-ylpropan-2-yl)quinoline-4-carboxamide
   Show/Hide
C25H22BrN3O
 1
1
IC50 = 500 nM
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CP0565171
4-[(6-bromo-3-methyl-2-phenylquinoline-4-carbonyl)amino]-3-(4-methoxyphenyl)butanoic acid
   Show/Hide
C28H25BrN2O4
 1
1
IC50 = 1100 nM
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CP0471861
6-bromo-3-methyl-N-(2-pyridin-3-ylethyl)-2-thiophen-2-ylquinoline-4-carboxamide
   Show/Hide
C22H18BrN3OS
 1
1
IC50 = 1800 nM
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CP0566004
6-bromo-3-methyl-2-phenyl-N-(2-pyridin-3-ylethyl)quinoline-4-carboxamide
   Show/Hide
C24H20BrN3O
 1
1
IC50 = 3400 nM
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   TS
CP0543684
6-bromo-N,3-dimethyl-2-phenyl-N-(2-pyridin-2-ylethyl)quinoline-4-carboxamide
   Show/Hide
C25H22BrN3O
 1
1
IC50 = 15000 nM
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