N-(3,5-dichloropyridin-4-yl)-1-[3-[(E)-2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-methylsulfonylphenyl)ethenyl]phenyl]-4-oxo-1,8-naphthyridine-3-carboxamide

8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline

1-(3'-Acetyl-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid (3,4-dichloro-pyridin-2-yl)-amide

8-(3-Azido-phenyl)-6-pyridin-4-ylmethyl-quinoline

5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-N-methyl-N-[(1R)-1-phenylethyl]pyridin-2-amine

1-(4'-Acetyl-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid isopropylamide

1-(3'-Acetyl-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid isopropylamide

8-(3-Azido-phenyl)-6-(4-iodo-imidazol-1-ylmethyl)-quinoline

2-[5-[1-[3-cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol

1-(4-chlorophenyl)-N-(3,5-dichloropyridin-4-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

4-{2-(3,4-Bis-difluoromethoxy-phenyl)-2-[4-(4-fluoro-phenoxymethyl)-phenyl]-ethyl}-pyridine 1-oxide

(S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-phenyl]-2-[5-(2-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoro)ethyl)-thiazolyl]ethyl}pyridine N-Oxide

2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-thiazol-2-yl}-propan-2-ol

3-Benzyl-5-phenyl-3,5-dihydro-1,3,5,6-tetraaza-cyclopenta[a]naphthalen-4-one

5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-N-ethyl-N-[(1R)-1-phenylethyl]pyridin-2-amine

1-(4'-Methanesulfonyl-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid isopropylamide

5-{2-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-2-[6-(1-hydroxy-1-methyl-ethyl)-pyridin-3-yl]-ethyl}-3H-pyridin-2-one

1-(4'-Methylsulfanyl-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid isopropylamide

5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-N-methyl-N-phenylpyridin-2-amine

2-[5-[1-[3-cyclobutyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol

2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-propan-2-ol

Benzyl-{5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-amine

Benzyl-{5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-methyl-amine

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(3-methyl-1-oxy-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

(E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(methylsulfonyl)phenyl)vinyl)phenyl)-6-(2-(methylsulfonyl)propan-2-yl)quinoline

5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-N-methyl-N-(naphthalen-2-ylmethyl)pyridin-2-amine

1-(3'-Ethoxy-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid isopropylamide

2-[4-[1-[3-cyclobutyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]propan-2-ol

5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-N-[(1R)-1-phenylethyl]pyridin-2-amine

1-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-1-phenyl-ethanol

2-{4'-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-biphenyl-3-yl}-2-methyl-propionic acid

Benzyl-{5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-ethyl-amine

5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-N-[2-(4-methylphenyl)ethyl]pyridin-2-amine

8-(3-Azido-phenyl)-6-iodo-quinoline

1-(4-{2-(3,4-Bis-difluoromethoxy-phenyl)-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-ethyl}-1-oxy-pyridin-3-yl)-ethanone

4-[2-(4-Chloro-phenyl)-2-(3-cyclopentyloxy-4-methoxy-phenyl)-ethyl]-pyridine

4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-N-(2-methyl-benzoyl)-benzenesulfonamide

8-(5-Azido-2-iodo-phenyl)-6-pyridin-4-ylmethyl-quinoline

1-(3-bromophenyl)-N-isobutyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

(R,S)-Rolipram

(R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-2-methyl-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

[4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]methyl N-ethylcarbamate

5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-N-methyl-N-(2-phenylethyl)pyridin-2-amine

1-{3-[6-(1-Hydroxy-1-methyl-ethyl)-1-oxy-pyridin-3-yl]-phenyl}-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid cyclopropylamide

4-Oxo-1-[3-(1-oxy-pyridin-3-ylethynyl)-phenyl]-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid cyclopropylamide

[4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]-(5-methylpyridin-2-yl)methanone

1-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-phenyl}-cyclobutanol

N-[5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]pyridin-2-yl]-2-phenylacetamide

1-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-3-ethyl-urea

4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-N,N-dimethyl-benzamide

6-Imidazol-1-ylmethyl-8-phenyl-quinoline

1-(3-bromophenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Benzyl-{5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-isopropyl-amine

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-phenyl}-propan-2-ol

4-[2-(3,4-Bis-difluoromethoxy-phenyl)-2-(4-chloro-phenyl)-ethyl]-pyridine

5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-N-propan-2-ylpyridin-2-amine

4-[2-(4-Chloro-phenyl)-2-(5-cyclopentyloxy-2-fluoro-4-methoxy-phenyl)-ethyl]-pyridine

4-[2-(4-Chloro-phenyl)-2-(3-cyclopentyloxy-4-difluoromethoxy-phenyl)-ethyl]-pyridine

[8-(3-iodophenyl)quinolin-6-yl]-phenylmethanone

4-oxo-1-phenyl-N-propan-2-yl-1,8-naphthyridine-3-carboxamide

1-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-phenyl}-cyclopropanol

N-[5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]pyridin-2-yl]benzenesulfonamide

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(2-methyl-1-oxy-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Benzyl-{5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-tert-butyl-amine

4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-benzoic acid

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(3-ethyl-1-oxy-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

6-Azido-8-(3-iodo-phenyl)-quinoline

5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-ylamine

4-[2-[3,4-di(difluoromethoxy)phenyl]-2-(6-tetrahydro-1H-1-pyrrolyl-3-pyridyl)ethyl]-1-pyridiniumolate

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-3-methyl-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

5-[1-(4-Chloro-phenyl)-2-pyridin-4-yl-ethyl]-2,3-bis-difluoromethoxy-pyridine 1-oxide

N-[5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]pyridin-2-yl]acetamide

4-(3-Cyclopentyloxy-4-methoxy-phenyl)-1-[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-pyrrolidin-2-one

(1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(3-hydroxymethyl-1-oxy-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

4-Hydroxy-7-{2-[2-(3-phenethyloxy-propane-1-sulfonyl)-ethylamino]-ethyl}-3H-benzothiazol-2-one

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-propyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

2-(4-{1-(3,4-Bis-difluoromethoxy-phenyl)-2-[3-(1-hydroxy-ethyl)-1-oxy-pyridin-4-yl]-ethyl}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol

[4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]methanol

1-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-phenyl}-ethanol

N-(3,4-dimethoxyphenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide

2-[5-[(1R)-1-[3-cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol

2-[4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]acetic acid

2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(3,5-dimethyl-1-oxy-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

1-(3-bromo-4-methylphenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

N-(3,5-dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

4-(3,4-dimethoxyphenyl)-N-pyridin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide

N-(3,4-dimethoxyphenyl)-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide

4-[2-(4-Chloro-phenyl)-2-(3-cyclopentyloxy-2-fluoro-4-methoxy-phenyl)-ethyl]-pyridine

1-(3-bromophenyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

3-[3-Iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-5-phenyl-3,5-dihydro-1,3,5,6-tetraaza-cyclopenta[a]naphthalen-4-one

N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide

4-[2-(4-Chloro-phenyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethyl]-pyridine

4-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine

(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione

(2S,8R)-2-(5-bromothiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione

(2S,8R)-6-methyl-2-(5-methylthiophen-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione

(2S,8R)-2-(5-ethylfuran-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione

(10S,15S)-13-ethyl-10-(5-methylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

(10S,15S)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

(10S,15R)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

(10S,15R)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

(10S,15S)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

(2S,8R)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione

(10S,15S)-13-butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

(10R,15R)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

(2R,8S)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione

(10S,15R)-13-butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

(10S,15S)-13-ethyl-10-(3-methylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione

4-[2-Benzo[1,3]dioxol-5-yl-2-(4-chloro-phenyl)-ethyl]-pyridine

1-(3-bromophenyl)-N-isopropyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

1-(3-bromophenyl)-N-isopropyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide