Brief Information of the Compound and Protein
Compound Name
(R,S)-Rolipram
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PubChem ID
CID: 5092
SID: 12013590
Canonical SMILES
COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
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Compound Formula C16H21NO3
Compound Structure
Protein Name
3',5'-cyclic-AMP phosphodiesterase 4A
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 4
>
Phosphodiesterase 4A
Uniprot ID
P27815
Gene Name
PDE4A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 95 nM
   TI
   LI
   LO
   TS
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
2
IC50 = 1950 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.770852 nM
2 IC50 = 10.7 nM
3 IC50 = 11 nM
4 IC50 = 67 nM
5 IC50 = 84 nM
6 IC50 = 162 nM
7 IC50 = 386 nM
8 IC50 = 830 nM