Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01173 , Histamine H3 receptor
Gene Name HRH3
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID Q9QYN8
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01173
 
Compound ID Compound Name Compound Formula
CP0090976
(R)-2-(4-methyl-2-(pyrrolidin-1-yl)pyrimidin-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
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C25H31N5
 2
1
EC50 = 3.02 nM
   TI
   LI
   LO
   TS
2
Ki = 1.95 nM
   TI
   LI
   LO
   TS
CP0085130
1-[6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]pyridin-3-yl]pyrrolidin-2-one
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C23H27N3O2
 1
1
Ki = 0.1479 nM
   TI
   LI
   LO
   TS
CP0193419
6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methylnicotinamide
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C21H25N3O2
 1
1
Ki = 0.6761 nM
   TI
   LI
   LO
   TS
CP0070912
3,5-dimethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,2-oxazole-4-carboxamide
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C22H30N4O2
 1
1
Ki = 0.9 nM
   TI
   LI
   LO
   TS
CP0091000
(R)-2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
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C24H27N5
 1
1
Ki = 0.91 nM
   TI
   LI
   LO
   TS
CP0198937
(R)-2-(1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
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C26H30N6O
 1
1
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0159421
5-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methylpyrazine-2-carboxamide
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C20H24N4O2
 1
1
Ki = 1.122 nM
   TI
   LI
   LO
   TS
CP0279719
3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2,5-dimethyl-4(3H)-quinazolinone
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C25H29N3O2
 1
1
Ki = 1.8 nM
   TI
   LI
   LO
   TS
CP0094412
3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2-methyl-5-(trifluoromethyl)-4(3H)-quinazolinone
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C25H26F3N3O2
 1
1
Ki = 2.3 nM
   TI
   LI
   LO
   TS
CP0126642
(R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
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C21H26N4
 1
1
Ki = 3.09 nM
   TI
   LI
   LO
   TS
CP0044006
(R)-2-methyl-3-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1,8-naphthyridine
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C25H26N4
 1
1
Ki = 3.55 nM
   TI
   LI
   LO
   TS
CP0194592
(R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile
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C22H22N2O
 1
1
Ki = 4.57 nM
   TI
   LI
   LO
   TS
CP0491234
US8796297, 25
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C8H13N5
 1
1
Ki = 5.75 nM
   TI
   LI
   LO
   TS
CP0221898
3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-5-fluoro-2-methyl-4(3H)-quinazolinone
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C24H26FN3O2
 1
1
Ki = 6 nM
   TI
   LI
   LO
   TS
CP0044094
(R)-2-(5-methyl-1-(pyridin-2-yl)-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
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C25H27N5
 1
1
Ki = 7.08 nM
   TI
   LI
   LO
   TS
CP0425035
4-(4-methylpiperazin-1-yl)pyrimidin-2-amine
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C9H15N5
 1
1
Ki = 7.41 nM
   TI
   LI
   LO
   TS
CP0385794
US8796297, 23
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C11H17N5
 1
1
Ki = 12.3 nM
   TI
   LI
   LO
   TS
CP0468445
US8796297, 6
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C7H13N5
 1
1
Ki = 13.2 nM
   TI
   LI
   LO
   TS
CP0425443
US8796297, 2
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C8H15N5
 1
1
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0544850
US8796297, 12
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C16H21N5
 1
1
Ki = 24.5 nM
   TI
   LI
   LO
   TS
CP0164197
2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone
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C23H24F3N3O2
 1
1
Ki = 33 nM
   TI
   LI
   LO
   TS
CP0411385
US8796297, 21
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C17H23N5
 1
1
Ki = 55 nM
   TI
   LI
   LO
   TS
CP0546588
US8796297, 20
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C9H15N5
 1
1
Ki = 58.9 nM
   TI
   LI
   LO
   TS
CP0470180
US8796297, 7
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C8H15N5
 1
1
Ki = 81.3 nM
   TI
   LI
   LO
   TS
CP0462718
US8796297, 22
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C7H11N5
 1
1
Ki = 97.7 nM
   TI
   LI
   LO
   TS
CP0462746
US8796297, 24
   Show/Hide
C9H15N5
 1
1
Ki = 105 nM
   TI
   LI
   LO
   TS
CP0411040
US8796297, 16
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C10H17N5
 1
1
Ki = 141 nM
   TI
   LI
   LO
   TS
CP0414030
US8796297, 4
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C7H13N5
 1
1
Ki = 162 nM
   TI
   LI
   LO
   TS
CP0429153
US8796297, 10
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C9H17N5
 1
1
Ki = 162 nM
   TI
   LI
   LO
   TS
CP0441410
US8796297, 18
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C8H13N5
 1
1
Ki = 162 nM
   TI
   LI
   LO
   TS
CP0539618
US8796297, 19
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C17H21N5
 1
1
Ki = 170 nM
   TI
   LI
   LO
   TS
CP0468440
US8796297, 8
   Show/Hide
C8H15N5
 1
1
Ki = 195 nM
   TI
   LI
   LO
   TS
CP0385078
US8796297, 3
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C9H17N5
 1
1
Ki > 309 nM
   TI
   LI
   LO
   TS
CP0470059
US8796297, 11
   Show/Hide
C9H17N5
 1
1
Ki > 316 nM
   TI
   LI
   LO
   TS
CP0475529
US8796297, 5
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C8H15N5
 1
1
Ki > 316 nM
   TI
   LI
   LO
   TS
CP0413795
US8796297, 15
   Show/Hide
C15H25N5O2
 1
1
Ki > 331 nM
   TI
   LI
   LO
   TS
CP0549770
US8796297, 17
   Show/Hide
C13H21N5O2
 1
1
Ki > 339 nM
   TI
   LI
   LO
   TS
CP0458991
US8796297, 14
   Show/Hide
C13H21N5O2
 1
1
Ki > 355 nM
   TI
   LI
   LO
   TS