Brief Information of the Compound and Protein
Compound Name
(R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile
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PubChem ID
CID: 9818903
SID: 14801907
Canonical SMILES
C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N
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Compound Formula C22H22N2O
Compound Structure
Protein Name
Histamine H3 receptor
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q9QYN8
Gene Name
HRH3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Ki = 3 nM
   TI
   LI
   LO
   TS
2
Ki = 31 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 4.57 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.45 nM
2 Ki = 1.23 nM
3 Ki = 1.4 nM