Brief Information of the Cell Line and Protein
Cell Line ID: CL000163 , COLO 205
 Cell Line Info 
Synonyms
Colo 205
CoLo 205
COLO-205
Colo-205
COLO.205
Colo205
COLO205
Co 205
Colorado 205
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0218
Protein ID: PT01080 , Dual specificity mitogen-activated protein kinase kinase 1
 Protein Info 
Gene Name MAP2K1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q02750
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000163
 Cell Line Info 
 Protein ID: PT01080
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0158653
 Compound Info 
Pimasertib
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C15H15FIN3O3
  1
1
IC50 = 1.81 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0116312
 Compound Info 
2-[(2S)-2,3-dihydroxypropyl]-8-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyridazin-1-one
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C16H14FIN4O3
  1
1
IC50 = 1.95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0382258
 Compound Info 
N-[(2S)-2,3-dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide
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C14H14FIN4O3
  1
1
IC50 = 3.41 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0027641
 Compound Info 
(R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
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C17H15F2IN4O4
  1
1
IC50 = 6.92 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0550678
 Compound Info 
2-[(2S)-2,3-dihydroxypropyl]-8-(2-fluoro-4-iodoanilino)-4-methylpyrido[3,4-d]pyridazin-1-one
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C17H16FIN4O3
  1
1
IC50 = 13.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0273467
 Compound Info 
2-chloro-N-[(2S)-2,3-dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide
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C14H13ClFIN4O3
  1
1
IC50 = 44.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0571209
 Compound Info 
N-(1,3-dihydroxypropan-2-yl)-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide
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C14H14FIN4O3
  1
1
IC50 = 55.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0554907
 Compound Info 
N-[(2R)-2,3-dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide
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C14H14FIN4O3
  1
1
IC50 = 56.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0273468
 Compound Info 
5-(2-fluoro-4-iodoanilino)-N-(3-hydroxypropyl)pyrimidine-4-carboxamide
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C14H14FIN4O2
  1
1
IC50 = 101.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0113690
 Compound Info 
5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethyl)pyrimidine-4-carboxamide
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C13H12FIN4O2
  1
1
IC50 = 101.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0317919
 Compound Info 
3-[(2S)-2,3-dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyrimidin-4-one
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C16H14FIN4O3
  1
1
IC50 = 108 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0095543
 Compound Info 
3-[(2R)-2,3-dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyrimidin-4-one
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C16H14FIN4O3
  1
1
IC50 = 142 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS