Brief Information of the Compound and Protein
Compound Name
(R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
    Show/Hide
PubChem ID
CID: 24963252
SID: 56261361
Canonical SMILES
Cn1c2ncn(C[C@@H](O)CO)c(=O)c2c(Nc2ccc(I)cc2F)c(F)c1=O
    Show/Hide
Compound Formula C17H15F2IN4O4
Compound Structure
Protein Name
Dual specificity mitogen-activated protein kinase kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
>
STE protein kinase STE7 family
Uniprot ID
Q02750
Gene Name
MAP2K1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000163 COLO 205 Homo sapiens (Human)  1
1
IC50 = 6.92 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.79 nM
2 IC50 = 3.2 nM