| Compound ID |
Compound Name |
Compound Formula |
|
CP0196357
|
US9447092, Comparator 1, Example 56
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|
C20H21BrN8
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0088050
|
US9447092, 1
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|
C22H23Cl2N7
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0350888
|
US9447092, 2
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|
C18H20ClN9O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0104826
|
US9447092, 3
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|
C19H22ClN9O
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0075920
|
4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-cyclobutylbenzamide
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|
C22H21ClN6O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0270630
|
4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-phenylbenzamide
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|
C24H19ClN6O2
|
2
|
| 1 |
IC50 = 107 nM
|
|
|
| 2 |
IC50 = 4110 nM
|
|
|
|
CP0204584
|
4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-pyridin-3-ylbenzamide
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|
C23H18ClN7O2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0104827
|
US9447092, Comparator 2, Example 57
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|
C22H25BrN8
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0296123
|
4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-pyridin-4-ylbenzamide
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|
C23H18ClN7O2
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0134032
|
(S)-2-(6-hydroxy-6-methylheptan-2-ylamino)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C19H28N6O
|
2
|
| 1 |
Ki = 0.59 nM
|
|
|
| 2 |
Ki < 1 nM
|
|
|
|
CP0046955
|
2-[2-(2-chlorophenoxy)ethylamino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile
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|
C19H19ClN6O
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0197142
|
2-[2-(2-fluorophenoxy)ethylamino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile
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|
C19H19FN6O
|
1
|
| 1 |
Ki < 1 nM
|
|
|
|
CP0654431
|
rac-2-(6-hydroxy-6-methylheptan-2-ylamino)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile hydrochloride
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|
C19H29ClN6O
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0018039
|
N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
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|
C23H28N8OS
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0046949
|
4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(2-phenoxyethylamino)pyridine-3-carbonitrile
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|
C19H20N6O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0110049
|
4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(2-pyridin-3-yloxyethylamino)pyridine-3-carbonitrile
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|
C18H19N7O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0507929
|
2-(6-hydroxy-6-methylheptylamino)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C19H28N6O
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0524751
|
2-(hexylthio)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C17H23N5S
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0047080
|
4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-[2-(6-methylpyridin-3-yl)oxyethylamino]pyridine-3-carbonitrile
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|
C19H21N7O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0060224
|
4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-[2-(2-methylpyridin-3-yl)oxyethylamino]pyridine-3-carbonitrile
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|
C19H21N7O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0476008
|
2-(6-hydroxyhexylamino)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C17H24N6O
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0488351
|
N-[4-[3-cyano-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl]sulfanylphenyl]acetamide
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|
C19H18N6OS
|
1
|
| 1 |
Ki = 5.3 nM
|
|
|
|
CP0046961
|
4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(2-pyridin-2-yloxyethylamino)pyridine-3-carbonitrile
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|
C18H19N7O
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0180239
|
2-[2-(6-ethylpyridin-3-yl)oxyethylamino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile
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|
C20H23N7O
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0495136
|
2-(6-hydroxyhexylthio)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C17H23N5OS
|
1
|
| 1 |
Ki = 8.5 nM
|
|
|
|
CP0482225
|
2-(6-hydroxy-6-methylheptylthio)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C19H27N5OS
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0046808
|
2-[2-(2,6-dimethylpyridin-3-yl)oxyethylamino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile
Show/Hide
|
C20H23N7O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0507928
|
2-(2-hydroxyethylamino)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C13H16N6O
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0473306
|
2-(6-aminohexylthio)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C17H24N6S
|
1
|
| 1 |
Ki = 28 nM
|
|
|
|
CP0046954
|
4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(2-pyridin-4-yloxyethylamino)pyridine-3-carbonitrile
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|
C18H19N7O
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0488356
|
(R)-2-(6-hydroxy-6-methylheptan-2-ylamino)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
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|
C19H28N6O
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0509403
|
N-[4-[3-cyano-6-[(5-methyl-1H-pyrazol-3-yl)amino]-4-phenylpyridin-2-yl]sulfanylphenyl]-2-methylpropanamide
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|
C26H24N6OS
|
1
|
| 1 |
Ki = 310 nM
|
|
|
